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FN1Note: The agenda and participant list for the workshop can be found at http://www.fnih.org/what-we-do/current-lectures-awards-and-events/problem-formulation-for-the-use-of-gene-drive-in-mosquitoesworkshop.
FN2Financial support: The work of the Center for Environmental Risk Assessment in conducting the workshop and preparation of this manuscript was supported by a grant from the Foundation for the National Institutes of Health.
FN3Authors' addresses: Andrew Roberts, Center for Environmental Risk Assessment, International Life Sciences Institute Research Foundation, Washington, DC, E-mail: firstname.lastname@example.org. Paulo Paes de Andrade, Department of Genetics, Federal University of Pernambuco, Recife, Brazil, E-mail: email@example.com. Fredros Okumu, Department of Biomedical and Environmental Science, Ifakara Health Institute, Mikocheni Dar es Salaam, Morogoro, Tanzania, E-mail: firstname.lastname@example.org. Hector Quemada, Donald Danforth Plant Science Center, Institute for International Crop Improvement, Saint Louis, MO, E-mail: email@example.com. Moussa Savadogo, New Partnership for Africa's Development, African Biosafety Network of Expertise, Ougadougou, Burkina Faso, E-mail: firstname.lastname@example.org. Jerome Amir Singh, Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal Science Division, Durban, South Africa, and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada, E-mail: email@example.com. Stephanie James, Foundation for National Institute of Health, Bethesda, MD, E-mail: firstname.lastname@example.org.
- The American Society of Tropical Medicine and Hygiene,
- Source: The American Journal of Tropical Medicine and Hygiene, Volume 96, Issue 3, Mar 2017, p. 530 - 533
oa Results from the Workshop “Problem Formulation for the Use of Gene Drive in Mosquitoes”
Reducing the incidence of malaria has been a public health priority for nearly a century. New technologies and associated vector control strategies play an important role in the prospect of sustained reductions. The development of the CRISPR/Cas9 gene editing system has generated new possibilities for the use of gene-drive constructs to reduce or alter vector populations to reduce malaria incidence. However, before these technologies can be developed and exploited, it will be necessary to understand and assess the likelihood of any potential harms to humans or the environment. To begin this process, the Foundation for the National Institutes of Health and the International Life Sciences Institute Research Foundation organized an expert workshop to consider the potential risks related to the use of gene drives in Anopheles gambiae for malaria control in Africa. The resulting discussion yielded a series of consensus points that are reported here.
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