1921
Volume 96, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Mycetoma is a chronic soft tissue infection caused by fungal or bacterial pathogens, and is endemic in tropical and subtropical regions. Cases in developed countries outside the mycetoma belt are rare and usually imported by immigrants. Sporadic cases have been reported in Israel. Unpublished cases in the participating medical centers are reported. In addition, a systematic review of the literature was performed. All published mycetoma cases diagnosed in Israel were included with relevant variables collected. Twenty-one cases of mycetoma were diagnosed in Israel between 1942 and 2015, including four unpublished cases and 17 published cases. The mean age at diagnosis was 42 years (range 23–73), and 16 of the patients were male. The foot was the primary involved organ. Fifteen patients were immigrants from Yemen, Ethiopia, and Sudan. Five cases were autochthonous. One case was travel related. Among patients who developed symptoms after immigration, the mean time from exposure to symptom onset was 5.6 years (range 1–10 years). The mean time from symptom onset to diagnosis was 6.6 years (range 0.2–35 years). The autochthonous cases demonstrate that Israel is endemic of mycetoma. The immigrant population represents two distinct waves of immigration to Israel in the past century. Two unpublished cases of Ethiopian immigrants are the first reported cases of mycetoma acquired in Ethiopia. The diagnostic and therapeutic challenges along with the epidemiological data emphasize the need of raising the awareness of physicians to this devastating condition even in developed countries.

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References

  1. Venkatswami S, Sankarasubramanian A, Subramanyam S, , 2012. The madura foot: looking deep. Int J Low Extrem Wounds 11: 3142.[Crossref] [Google Scholar]
  2. Lichon V, Khachemoune A, , 2006. Mycetoma, a review. Am J Clin Dermatol 7: 315321.[Crossref] [Google Scholar]
  3. Zijlstra EE, Van de Sande WWJ, Welsh O, Mahgoub ES, Goodfellow M, Fahal AH, , 2016. Mycetoma: a unique neglected tropical disease. Lancet Infect Dis 16: 100112.[Crossref] [Google Scholar]
  4. Nenoff P, Van de Sande WWJ, Fahal AH, Reinel D, Schöfer H, , 2015. Eumycetoma and actinomycetoma: an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy. J Eur Acad Dermatol Venereol 29: 18731883.[Crossref] [Google Scholar]
  5. Buonfrate D, Gobbi F, Angheben A, Marocco S, Farina C, Van Den Ende J, Bisoffi Z, , 2014. Autochthonous cases of mycetoma in Europe: report of two cases and review of literature. PLoS One 9: e100590.[Crossref] [Google Scholar]
  6. Rouphael NG, Talati NJ, Franco-Paredes C, , 2007. A painful thorn in the foot: a case of eumycetoma. Am J Med Sci 334: 142144.[Crossref] [Google Scholar]
  7. Foltz KD, Fallat LM, , 2004. Madura foot: atypical finding and case presentation. J Foot Ankle Surg 43: 327331.[Crossref] [Google Scholar]
  8. Dostrovsky A, Sagher F, , 1942. Madura disease in Israel [in Hebrew]. Harefuah 13: 103105. [Google Scholar]
  9. Dostrovsky A, Sagher F, , 1948. Failure of sulphonamides and penicillin in maduromycosis. Lancet 1: 177178.[Crossref] [Google Scholar]
  10. Dostrovsky A, Raubitschek KF, Sagher F, , 1952. A case of black grain mycetoma caused by a Madurella species. Dermatologica 104: 415423.[Crossref] [Google Scholar]
  11. Ziprkowsky L, Altmann G, Dalith F, Spitz U, , 1957. Mycetoma pedis; four cases treated with streptomycin. AMA Arch Derm 75: 855863.[Crossref] [Google Scholar]
  12. Schewach Millet M, Ziprkowski L, Feinstein A, Cvibah T, , 1973. Mycetoma pedis, a report of two cases. Isr J Med Sci 9: 900903. [Google Scholar]
  13. Alteras I, Feuerman EJ, Dayan I, , 1980. Mycetoma due to Nocardia caviae. The first Israeli patient. Int J Dermatol 19: 260262.[Crossref] [Google Scholar]
  14. Landau Z, Feld S, Frumkin A, Resnitzky P, , 1986. Nocardia brasiliensis skin infections. Isr J Med Sci 22: 397399. [Google Scholar]
  15. Alteras I, Feuerman EJ, , 1986. The second case of mycetoma due to Nocardia caviae in Israel. Mycopathologia 93: 185187.[Crossref] [Google Scholar]
  16. Alteras I, Abraham D, Ideses C, Segal R, Sandbank M, , 1988. Mycetoma of the forearm due to Actinomadura madurae . Mycopathologia 103: 5557.[Crossref] [Google Scholar]
  17. Alteras I, Hagler J, Trattner A, Morojinski G, Segal R, Sandbank M, , 1992. Mycetoma with black granules: first case in a native of Israel [in German]. Hautarzt 43: 446447. [Google Scholar]
  18. Tamir G, Adler A, Hagler J, Hauben DJ, Goldberg I, , 1995. Mycetoma of the foot: surgical treatment with free flap reconstruction. Eur J Plast Surg 18: 124126. [Google Scholar]
  19. Chazan B, Colodner R, Polacheck I, Shoufani A, Rozenman D, Raz R, , 2004. Mycetoma of the foot caused by Cylindrocarpon lichenicola in an immunocompetent traveler. J Travel Med 11: 331332.[Crossref] [Google Scholar]
  20. Brufman T, Ben-Ami R, Mizrahi M, Bash E, Paran Y, , 2015. Mycetoma of the foot caused by Madurella mycetomatis in immigrants from Sudan. Isr Med Assoc J 17: 418420. [Google Scholar]
  21. Raubitschek F, , 1958. A critical survey of medical mycology in Israel 1946–1956. Mycopathol Mycol Appl 9: 176182.[Crossref] [Google Scholar]
  22. Kuttin ES, Beemer AM, , 1977. Systemic mycoses in Israel. Contrib Microbiol Immunol 4: 4655. [Google Scholar]
  23. Bryceson A, , 2000. Philoctetes' foot. Lancet 355: 850.[Crossref] [Google Scholar]
  24. Schwartz E, Shpiro A, , 2015. Madura foot or Philoctetes foot? Isr Med Assoc J 17: 442444. [Google Scholar]
  25. Hershkovitz I, Speirs M, Katznelson A, Arensburg B, , 1992. Unusual pathological condition in the lower extremities of a skeleton from ancient Israel. Am J Phys Anthropol 88: 2326.[Crossref] [Google Scholar]
  26. Spigelman M, Donoghue HD, , 2001. Brief communication: unusual pathological condition in the lower extremities of a skeleton from ancient Israel. Am J Phys Anthropol 114: 9293.[Crossref] [Google Scholar]
  27. Clemow FG, , 1906. Mycetoma (madura foot) in the Yemen. BMJ 1: 918919.[Crossref] [Google Scholar]
  28. Yu AM, Zhao S, Nie LY, , 1993. Mycetomas in northern Yemen: identification of causative organisms and epidemiologic considerations. Am J Trop Med Hyg 48: 812817.[Crossref] [Google Scholar]
  29. Khatri ML, Al-Halali HM, Fouad Khalid M, Saif SA, Vyas MCR, , 2002. Mycetoma in Yemen: clinicoepidemiologic and histopathologic study. Int J Dermatol 41: 586593.[Crossref] [Google Scholar]
  30. Van De Sande WWJ, Vinetz JM, , 2013. Global burden of human mycetoma: a systematic review and meta-analysis. PLoS Negl Trop Dis 7: e2550.[Crossref] [Google Scholar]
  31. The Israeli Central Bureau of Statistics, 2015. The Ethiopian Population in Israel [In Hebrew]. Available at: http://www.cbs.gov.il/reader/newhodaot/hodaa_template.html?hodaa=201511302. Accessed May 12, 2016. [Google Scholar]
  32. Israeli Authority of Immigration and Population, 2016. Reports of Foreigners in Israel [In Hebrew]. Available at: https://www.gov.il/he/Departments/publications/reports/foreign_workers_report_q1_2016. Accessed May 12, 2016. [Google Scholar]
  33. Fahal A, Sheikh Mahgoub E, El Hassan AM, Abdel-Rahman ME, , 2015. Mycetoma in the Sudan: an update from the Mycetoma Research Centre, University of Khartoum, Sudan. PLoS Negl Trop Dis 9: e0003679.[Crossref] [Google Scholar]
  34. Pelzer K, Tietz HJ, Sterry W, Haas N, , 2000. Isolation of both Sporothrix schenckii and Nocardia asteroides from a mycetoma of the forefoot. Br J Dermatol 143: 13111315.[Crossref] [Google Scholar]
  35. Douwes KE, Schmalzbauer E, Linde H-J, Reisberger EM, Fleischer K, Lehn N, Landthaler M, Vogt T, , 2003. Branched filaments no fungus, ovoid bodies no bacteria: two unusual cases of mycetoma. J Am Acad Dermatol 49: S170S173.[Crossref] [Google Scholar]
  36. Fletcher CL, Moore MK, Hay RJ, , 2001. Eumycetoma due to Madurella mycetomatis acquired in Jamaica. Br J Dermatol 145: 10181021.[Crossref] [Google Scholar]
  37. Turner PG, , 1989. Madura foot or plantar fibromatosis. J Bone Joint Surg Br 71: 531. [Google Scholar]
  38. Verdolini R, Amerio P, Bugatti L, Manso E, Cataldi I, Brancorsini D, Nicolini M, Filosa G, Giangioacomi M, , 2000. Madura's foot: report of a case caused by Madurella mycetomatis . Eur J Dermatol 10: 627629. [Google Scholar]
  39. Ichinomiya A, Nishimura K, Takenaka M, Utani A, Nishimoto K, , 2014. Mycetoma caused by Nocardia transvalensis with repeated local recurrences for 25 years without dissemination to viscera. J Dermatol 41: 556557.[Crossref] [Google Scholar]
  40. Van De Sande WWJ, Sheikh Maghoub E, Fahal AH, Goodfellow M, Welsh O, Zijlstra E, , 2014. The mycetoma knowledge gap: identification of research priorities. PLoS Negl Trop Dis 8: e2667.[Crossref] [Google Scholar]
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  • Received : 29 Aug 2016
  • Accepted : 05 Jan 2017
  • Published online : 03 Apr 2017

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