1921
Volume 96, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Currently, impact of schistosomiasis control programs in –endemic areas is monitored primarily by assessment of parasitologic indicators only. Our study was conducted to evaluate the use of antibody responses as a way to measure the impact of schistosomiasis control programs. A total of 3,612 serum samples collected at three time points from children 1–5 years of age were tested for antibody responses to two schistosome antigens (soluble egg antigen [SEA] and Sm25) by multiplex bead assay. The overall prevalence of antibody responses to SEA was high at baseline (50.0%). After one round of mass drug administration (MDA), there was minimal change in odds of SEA positivity (odds ratio [OR] = 1.02, confidence interval [CI] = 0.79–1.32, = 0.89). However, after two rounds of treatment, there was a slight decrease in odds of SEA positivity (OR = 0.80, CI = 0.63–1.02, = 0.08). In contrast to the SEA results, prevalence of antibody responses to Sm25 was lowest at baseline (14.1%) and higher in years 2 (19.8%) and 3 (18.4%). After one round of MDA, odds of Sm25 positivity increased significantly (OR = 1.51, CI = 1.14–2.02, = 0.005) and remained significantly higher than baseline after two rounds of MDA (OR = 1.37, CI = 1.07–1.76, = 0.01). There was a significant decrease in the proportion of 1-year-olds with positive SEA responses from 33.1% in year 1 to 13.2% in year 3 and a corresponding decrease in the odds (OR = 3.25, CI = 1.75–6.08, < 0.001). These results provide preliminary evidence that schistosomiasis program impact can be monitored using serologic responses.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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2017-11-23
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References

  1. WHO, 2015. Schistosomiasis: number of people treated worldwide in 2013. Wkly Epidemiol Rec 90: 2532.
  2. King CH, Dangerfield-Cha M, , 2008. The unacknowledged impact of chronic schistosomiasis. Chronic Illn 4: 6579.[Crossref]
  3. WHO, 2011. Helminth Control in School-Age Children: A Guide for Managers of Control Programmes. Geneva, Switzerland: WHO.
  4. Ekpo UF, Oluwole AS, Abe EM, Etta HE, Olamiju F, Mafiana CF, , 2012. Schistosomiasis in infants and pre-school-aged children in sub-Saharan Africa: implication for control. Parasitology 139: 835841.[Crossref]
  5. Sousa-Figueiredo JC, Pleasant J, Day M, Betson M, Rollinson D, Montresor A, Kazibwe F, Kabatereine NB, Stothard JR, , 2010. Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing pole. Int Health 2: 103113.[Crossref]
  6. Stothard JR, Sousa-Figueiredo JC, Betson M, Adriko M, Arinaitwe M, Rowell C, Besiyge F, Kabatereine NB, , 2011. Schistosoma mansoni infections in young children: when are schistosome antigens in urine, eggs in stool and antibodies to eggs first detectable? PLoS Negl Trop Dis 5: e938.[Crossref]
  7. Stothard JR, Sousa-Figueiredo JC, Betson M, Bustinduy A, Reinhard-Rupp J, , 2013. Schistosomiasis in African infants and preschool children: let them now be treated! Trends Parasitol 29: 197205.[Crossref]
  8. Verani JR, Abudho B, Montgomery SP, Mwinzi PN, Shane HL, Butler SE, Karanja DM, Secor WE, , 2011. Schistosomiasis among young children in Usoma, Kenya. Am J Trop Med Hyg 84: 787791.[Crossref]
  9. Betson M, Sousa-Figueiredo JC, Kabatereine NB, Stothard JR, , 2012. Use of fecal occult blood tests as epidemiologic indicators of morbidity associated with intestinal schistosomiasis during preventive chemotherapy in young children. Am J Trop Med Hyg 87: 694700.[Crossref]
  10. Betson M, Sousa-Figueiredo JC, Rowell C, Kabatereine NB, Stothard JR, , 2010. Intestinal schistosomiasis in mothers and young children in Uganda: investigation of field-applicable markers of bowel morbidity. Am J Trop Med Hyg 83: 10481055.[Crossref]
  11. Green HK, Sousa-Figueiredo JC, Basanez MG, Betson M, Kabatereine NB, Fenwick A, Stothard JR, , 2011. Anaemia in Ugandan preschool-aged children: the relative contribution of intestinal parasites and malaria. Parasitology 138: 15341545.[Crossref]
  12. Magalhaes RJ, Clements AC, , 2011. Mapping the risk of anaemia in preschool-age children: the contribution of malnutrition, malaria, and helminth infections in west Africa. PLoS Med 8: e1000438.[Crossref]
  13. Davis SM, Wiegand RE, Mulama F, Kareko EI, Harris R, Ochola E, Samuels AM, Rawago F, Mwinzi PM, Fox LM, Odiere MR, Won KY, , 2015. Morbidity associated with schistosomiasis before and after treatment in young children in Rusinga Island, western Kenya. Am J Trop Med Hyg 92: 952958.[Crossref]
  14. WHO, 1991. Basic Laboratory Methods in Medical Parasitology. Geneva, Switzerland: World Health Organization.
  15. Mwinzi PN, Kittur N, Ochola E, Cooper PJ, Campbell CH, Jr King CH, Colley DG, , 2015. Additional evaluation of the point-of-contact circulating cathodic antigen assay for Schistosoma mansoni infection. Front Public Health 3: 48.[Crossref]
  16. Nikolay B, Brooker SJ, Pullan RL, , 2014. Sensitivity of diagnostic tests for human soil-transmitted helminth infections: a meta-analysis in the absence of a true gold standard. Int J Parasitol 44: 765774.[Crossref]
  17. Colley DG, Binder S, Campbell C, King CH, Tchuem Tchuente LA, N'Goran EK, Erko B, Karanja DM, Kabatereine NB, van Lieshout L, Rathbun S, , 2013. A five-country evaluation of a point-of-care circulating cathodic antigen urine assay for the prevalence of Schistosoma mansoni . Am J Trop Med Hyg 88: 426432.[Crossref]
  18. Tchuem Tchuente LA, Kuete Fouodo CJ, Kamwa Ngassam RI, Sumo L, Dongmo Noumedem C, Kenfack CM, Gipwe NF, Nana ED, Stothard JR, Rollinson D, , 2012. Evaluation of circulating cathodic antigen (CCA) urine-tests for diagnosis of Schistosoma mansoni infection in Cameroon. PLoS Negl Trop Dis 6: e1758.[Crossref]
  19. Foo KT, Blackstock AJ, Ochola EA, Matete DO, Mwinzi PN, Montgomery SP, Karanja DM, Secor WE, , 2015. Evaluation of point-of-contact circulating cathodic antigen assays for the detection of Schistosoma mansoni infection in low-, moderate-, and high-prevalence schools in western Kenya. Am J Trop Med Hyg 92: 12271232.[Crossref]
  20. Lammie PJ, Moss DM, Brook Goodhew E, Hamlin K, Krolewiecki A, West SK, Priest JW, , 2012. Development of a new platform for neglected tropical disease surveillance. Int J Parasitol 42: 797800.[Crossref]
  21. Minakawa N, Kongere JO, Dida GO, Ikeda E, Hu J, Minagawa K, Futami K, Kawada H, Njenga SM, Larson PS, , 2015. Sleeping on the floor decreases insecticide treated bed net use and increases risk of malaria in children under 5 years of age in Mbita District, Kenya. Parasitology 142: 15161522.[Crossref]
  22. Odiere MR, Rawago FO, Ombok M, Secor WE, Karanja DM, Mwinzi PN, Lammie PJ, Won K, , 2012. High prevalence of schistosomiasis in Mbita and its adjacent islands of Lake Victoria, western Kenya. Parasit Vectors 5: 278.[Crossref]
  23. Government of Kenya Ministry of Health, 2002. Clinical Guidelines for Diagnosis and Treatment of Common Conditions in Kenya. The Regal Press Kenya Ltd., 190202.
  24. WHO, 2011. Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. Geneva, Switzerland: World Health Organization.
  25. Carter CE, Colley DG, , 1978. An electrophoretic analysis of Schistosoma mansoni soluble egg antigen preparation. J Parasitol 64: 285290.[Crossref]
  26. Ali PO, Jeffs SA, Meadows HM, Hollyer T, Owen CA, Abath FG, Allen R, Hackett F, Smithers SR, Simpson AJ, , 1991. Structure of Sm25, an antigenic integral membrane glycoprotein of adult Schistosoma mansoni . Mol Biochem Parasitol 45: 215222.[Crossref]
  27. Tsang VC, Hancock K, Kelly MA, Wilson BC, Maddison SE, , 1983. Schistosoma mansoni adult microsomal antigens, a serologic reagent. II. Specificity of antibody responses to the S. mansoni microsomal antigen (MAMA). J Immunol 130: 13661370.
  28. Moss DM, Priest JW, Boyd A, Weinkopff T, Kucerova Z, Beach MJ, Lammie PJ, , 2011. Multiplex bead assay for serum samples from children in Haiti enrolled in a drug study for the treatment of lymphatic filariasis. Am J Trop Med Hyg 85: 229237.[Crossref]
  29. Hamlin KL, Moss DM, Priest JW, Roberts J, Kubofcik J, Gass K, Streit TG, Nutman TB, Eberhard ML, Lammie PJ, , 2012. Longitudinal monitoring of the development of antifilarial antibodies and acquisition of Wuchereria bancrofti in a highly endemic area of Haiti. PLoS Negl Trop Dis 6: e1941.[Crossref]
  30. Rao JNSA, , 1984. On chi-sqaured tests for multiway contingency tables with cell proportions estimated from survey data. Ann Stat 12: 4660.[Crossref]
  31. Binder DA, , 1983. On the variances of asymptotically normal estimators from complex surveys. Int Stat Rev 51: 279292.[Crossref]
  32. King CH, , 2015. It's time to dispel the myth of “asymptomatic” schistosomiasis. PLoS Negl Trop Dis 9: e0003504.[Crossref]
  33. Secor WE, , 2015. Early lessons from schistosomiasis mass drug administration programs. F1000 Res 4: F1000 Faculty Rev-1157.
  34. Sang HC, Muchiri G, Ombok M, Odiere MR, Mwinzi PN, , 2014. Schistosoma haematobium hotspots in south Nyanza, western Kenya: prevalence, distribution and co-endemicity with Schistosoma mansoni and soil-transmitted helminths. Parasit Vectors 7: 125.[Crossref]
  35. Handzel T, Karanja DM, Addiss DG, Hightower AW, Rosen DH, Colley DG, Andove J, Slutsker L, Secor WE, , 2003. Geographic distribution of schistosomiasis and soil-transmitted helminths in western Kenya: implications for anthelminthic mass treatment. Am J Trop Med Hyg 69: 318323.
  36. Woodhall DM, Wiegand RE, Wellman M, Matey E, Abudho B, Karanja DM, Mwinzi PM, Montgomery SP, Secor WE, , 2013. Use of geospatial modeling to predict Schistosoma mansoni prevalence in Nyanza Province, Kenya. PLoS One 8: e71635.[Crossref]
  37. Arnold BF, Priest JW, Hamlin KL, Moss DM, Colford JM, Jr Lammie PJ, , 2014. Serological measures of malaria transmission in Haiti: comparison of longitudinal and cross-sectional methods. PLoS One 9: e93684.[Crossref]
  38. Cook J, Reid H, Iavro J, Kuwahata M, Taleo G, Clements A, McCarthy J, Vallely A, Drakeley C, , 2010. Using serological measures to monitor changes in malaria transmission in Vanuatu. Malar J 9: 169.[Crossref]
  39. Drakeley CJ, Corran PH, Coleman PG, Tongren JE, McDonald SL, Carneiro I, Malima R, Lusingu J, Manjurano A, Nkya WM, Lemnge MM, Cox J, Reyburn H, Riley EM, , 2005. Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure. Proc Natl Acad Sci USA 102: 51085113.[Crossref]
  40. Dewi RM, Tuti S, Ganefa S, Anwar C, Larasati R, Ariyanti E, Herjati H, Brady M, , 2015. Brugia rapid antibody responses in communities of Indonesia in relation to the results of ‘transmission assessment surveys’ (TAS) for the lymphatic filariasis elimination program. Parasit Vectors 8: 499.[Crossref]
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  • Received : 15 Aug 2016
  • Accepted : 16 Nov 2016

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