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FN1Authors' addresses: Rania A. Zayed and Doha A. Mokhtar, Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, E-mails: email@example.com and firstname.lastname@example.org. Dalia Omran and Zinab Zakaria, Department of Endemic Medicine and Hepato-gastroentrology, Faculty of Medicine, Cairo University, Cairo, Egypt, E-mails: email@example.com and firstname.lastname@example.org. Sameera Ezzat, Community Medicine Department, National Liver Institute, Menofia University, Menofia, Egypt, E-mail: email@example.com. Mohamed A. Soliman, Specialized Liver Unit, Kasr Alainy Hospital, Cairo University, Cairo, Egypt, E-mail: firstname.lastname@example.org. Lamiaa Mobarak, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt, E-mail: email@example.com. Hossam El-Sweesy, Tropical Medicine Department, Cairo Fatemic Hospital, Ministry of Health, Cairo, Egypt, E-mail: firstname.lastname@example.org. Ghada Emam, Clinical Pathology Department, NINMS, Cairo, Egypt, E-mail: email@example.com.
- The American Society of Tropical Medicine and Hygiene,
- Source: The American Journal of Tropical Medicine and Hygiene, Volume 96, Issue 3, Mar 2017, p. 720 - 726
Association of Toll-Like Receptor 3 and Toll-Like Receptor 9 Single Nucleotide Polymorphisms with Hepatitis C Virus Infection and Hepatic Fibrosis in Egyptian Patients
Toll-like receptors (TLRs) are recognized as fundamental contributors to the immune system function against infections. Hepatitis C virus (HCV) infection represents a global health problem especially in Egypt having the highest HCV prevalence worldwide where HCV infection is a continuing epidemic. The aim of the present study was to investigate the possible association between genetic variation in TLR-3 and TLR-9 and HCV infection and hepatic fibrosis in chronic HCV-positive Egyptian patients. The present study included 100 naïve chronic HCV-positive patients and 100 age- and sex-matched healthy controls. Genotyping of TLR-3 (_7 C/A [rs3775296]), TLR-3 (c.1377C/T [rs3775290]) and TLR-9 (1237T/C [rs5743836]) were done by polymerase chain reaction restriction fragment length polymorphism technique. Frequency of polymorphic genotypes in TLR-3 (_7 C/A), TLR-3 (c.1377C/T) and TLR-9 (1237T/C) were not significantly different between studied HCV-positive patients and controls with P values 0.121, 0.112, and 0.683, respectively. TLR-3 c.1377 T-allele was associated with advanced stage of hepatic fibrosis (P = 0.003).