1921
Volume 96, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Human coronavirus (HCoV) NL63 is recognized as a common cause of upper respiratory infections and influenza-like illness. In screening children with acute undifferentiated febrile illness in a school cohort in rural Haiti, we identified HCoV-NL63 in blood samples from four children. Cases clustered over an 11-day period; children did not have respiratory symptoms, but two had gastrointestinal complaints. On phylogenetic analysis, the Haitian HCoV-NL63 strains cluster together in a highly supported monophyletic clade linked most closely with recently reported strains from Malaysia; two respiratory HCoV-NL63 strains identified in north Florida in the same general period form a separate clade, albeit again with close linkages with the Malaysian strains. Our data highlight the variety of presentations that may be seen with HCoV-NL63, and underscore the apparent ease with which CoV strains move among countries, with our data consistent with recurrent introduction of strains into the Caribbean (Haiti and Florida) from Asia.

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2017-01-11
2018-07-20
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References

  1. Berry M, Gamieldien J, Felding BC, , 2015. Identification of new respiratory viruses in the new millennium. Viruses 5: 9961019.[Crossref]
  2. Yip CCY, Lam CSF, Luk HKH, Wong EYM, Lee RA, So L-Y, Chan K-H, Cheng ACC, Yuen K-Y, Woo PCY, Lau SKP, , 2016. A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong. Virol Sin 31: 4148.[Crossref]
  3. Owusu M, Annan A, Corman VM, Larbi R, Anti P, Drexler JF, Agbenyega O, Adu-Sarkodie Y, Drosten C, , 2014. Human coronavirus associated with upper respiratory tract infections in three rural areas of Ghana. PLoS One 9: e99782.[Crossref]
  4. Matoba Y, Abiko C, Ikeda T, Aoki Y, Suzuki Y, Yahagi K, Matsuzaki Y, Itagaki T, Katsushima F, Katsushima Y, Mizuta K, , 2015. Detection of human coronavirus 229E, HKU1, NL63, and OC43 between 2010 and 2013 in Yamagata, Japan. Jpn J Infect Dis 68: 138141.[Crossref]
  5. Huang S-H, Su M-C, Tien N, Huang C-J, Lan Y-C, Lin C-S, Chen C-H, Lin C-W, , 2015. Epidemiology of human coronavirus NL63 infection among hospitalized patients with pneumonia in Taiwan. J Microbiol Immunol Infect. doi: 10.1016/j.jmii.2015.10.008.
  6. Razuri JH, Malecki M, Tinoco Y, Ortiz E, Guezala MC, Romero C, Estela A, Brena P, Morales M-L, Reaves EJ, Gomez J, Uyeki TM, Widdowson M-A, Azziz-Baumgartner E, Bausach DG, Schildgen V, Schildgen O, Montgomery JM, , 2015. Human coronavirus-associated influenza-like illness in the community setting in Peru. Am J Trop Med Hyg 93: 10381040.[Crossref]
  7. Lee J, Storch GA, , 2014. Characterization of human coronavirus OC43 and human coronavirus NL63 infections among hospitalized children <5 years of age. Pediatr Infect Dis J 33: 814820.[Crossref]
  8. Trombetta H, Faggion HZ, Leotte J, Nogueira MB, Vidal LRR, Raboni SM, , 2016. Human coronavirus and severe acute respiratory infection in southern Brazil. Pathog Glob Health 110: 113118.[Crossref]
  9. Hu B, Ge X, Wang L-F, Shi Z, , 2015. Bat origin of human coronaviruses. Virol J 12: 221.[Crossref]
  10. Huynh J, Li S, Yount B, Smith A, Sturges L, Olsen JC, Nagel J, Johnson JB, Agnihothram S, Gates JE, Frieman MB, Baric RS, Donaldson EF, , 2012. Evidence supporting a zoonotic origin of human coronavirus strain NL63. J Virol 86: 1281612825.[Crossref]
  11. Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ, SARS Working Group, , 2003. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 348: 19531966.[Crossref]
  12. de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuances L, Rouchier RAM, Galiano M, Gorbalenya AE, Memish ZA, Perlman S, Poon LLM, Snijder EJ, Stephens GM, Woo PCY, Zaki AM, Zambon M, Ziebuhr J, , 2013. Middle east respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol 87: 77907792.[Crossref]
  13. Beau De Rochars VEM, Alam MT, Telisma T, Masse R, Chavannes S, Anilis MG, Guillaume JH, Gelin G, Kirkpatrick EL, Desormeaux A-M, Okech BA, Weppelmann TA, Rashid M, Karst S, Johnson JA, Ali A, Morris JG, Jr, 2015. Spectrum of outpatient illness in a school-based cohort in Haiti, with a focus on diarrheal pathogens. Am J Trop Med Hyg 92: 752757.[Crossref]
  14. Lednicky J, Beau de Rochars VM, El Badry M, Loeb J, Telisma T, Chavannes S, Anilis G, Cella E, Ciccozzi M, Rashid M, Okech B, Salemi M, Morris JG, Jr, 2016. Zika virus outbreak in Haiti in 2014: molecular and clinical data. PLoS Negl Trop Dis 10: e0004687.[Crossref]
  15. El Badry M, Lednicky J, Cella E, Telisma T, Chavannes S, Loeb J, Ciccozzi M, Okech B, Beau De Rochars VM, Salemi M, Morris JG, Jr, 2016. Isolation of an entervirus D68 from blood of a child with pneumonia in rural Haiti: close phylogenetic linkage with New York strain. Ped Infect Dis J 35: 10481050.[Crossref]
  16. Posada D, Buckley TR, , 2004. Model selection and model averaging in phylogenetics: advantages of akaike information criterion and bayesian approaches over likelihood ratio tests. Syst Biol 53: 793808.[Crossref]
  17. Al-Khannaq MN, Ng KT, Oong XY, Pang YK, Takebe Y, Chook JB, Hanafi NS, Kamarulzaman A, Tee KK, , 2016. Diversity and evolutionary histories of human coronaviruses NL63 and 229E associated with acute upper respiratory tract symptoms in Kuala Lumpur, Malaysia. Am J Trop Med Hyg 94: 10581064.[Crossref]
  18. Risku M, Lappalainen S, Rasanen S, Vesikari T, , 2010. Detection of human coronaviruses in children with acute gastroenteritis. J Clin Virol 48: 2730.[Crossref]
  19. Lednicky JA, Waltzek TB, McGeehan E, Loeb JC, Hamilton SB, Luetke MC, , 2013. Isolation and genetic characterization of human coronavirus NL63 in primary human renal proximal tubular epithelial cells obtained from a commercial supplier, and confirmation of its replication in two different types of human primary kidney cells. Virol J 10: 213.[Crossref]
  20. Cowling BJ, Park M, Fang VJ, Wu P, Leung GM, Wu JT, , 2015. Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, May to June 2015. Euro Surveill 20: 21163.[Crossref]
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Supplementary Data

Supplemental Information, Table, and Figures

  • Received : 19 Jul 2016
  • Accepted : 16 Sep 2016

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