1921
Volume 96, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Dried blood spots (DBS) were collected from 805 children attending 42 elementary schools in the regions of Mopti, Sikasso, Koulikoro, and the regional capital of Bamako in Mali as part of an evaluation of a school health intervention. Eluted immunoglobulin (Ig) G from the DBS was assessed by a multiplex bead assay (MBA) for two filariasis antigens, , Wb123, and , Bm14, to determine the effectiveness of mass drug administration (MDA) programs to eliminate lymphatic filariasis (LF). The prevalence of positive IgG responses in the children to each antigen was less than 1%, indicating effectiveness of the MDA against LF. The MBA is an excellent serological platform that provides cost-effective opportunities to evaluate public health activities beyond the survey targets.

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2017-01-11
2018-09-20
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References

  1. World Health Organization, 2015. Lymphatic Filariasis Epidemiology. Available at: http://www.who.int/lymphatic_filariasis/epidemiology/en/. Accessed December 30, 2015.
  2. World Health Organization, 2012. Accelerating Work to Overcome the Global Impact of Neglected Tropical Diseases: A Roadmap for Implementation. Available at: http://www.who.int/neglected_diseases/NTD_RoadMap_2012_Fullversion.pdf. Accessed February, 2016.
  3. Hooper PJ, Chu BK, Mikhailov A, Ottesen EA, Bradley M, , 2014. Assessing progress in reducing the at-risk population after 13 years of the global programme to eliminate lymphatic filariasis. PLoS Negl Trop Dis 8: e3333.[Crossref]
  4. Ramaiah KD, Ottesen EA, , 2014. Progress and impact of 13 years of the global programme to eliminate lymphatic filariasis on reducing the burden of filarial disease. PLoS Negl Trop Dis 8: e3319.[Crossref]
  5. Coulibaly YI, Dembele B, Diallo AA, Konate S, Dolo H, Coulibaly SY, Doumbia SS, Soumaoro L, Coulibaly ME, Bockarie MJ, Molyneux D, Nutman TB, Klion AD, Toure YT, Traore SF, , 2015. The impact of six annual rounds of mass drug administration on Wuchereria bancrofti infections in humans and in mosquitoes in Mali. Am J Trop Med Hyg 93: 356360.[Crossref]
  6. Coulibaly YI, Dembele B, Diallo AA, Kristensen S, Konate S, Dolo H, Dicko I, Sangare MB, Keita F, Boatin BA, Traore AK, Nutman TB, Klion AD, Toure YT, Traore SF, , 2013. Wuchereria bancrofti transmission pattern in southern Mali prior to and following the institution of mass drug administration. Parasit Vectors 6: 247.[Crossref]
  7. Envision, 2016. Mali Work Plan, FY 2016, Project Year 5. October 2015–September 2016. Available at: http://ntdenvision.org/sites/default/files/docs/envision_fy_16_mali_country.pdf. Accessed February 2016.
  8. Trinies V, Garn JV, Chang HH, Freeman MC, , 2016. The impact of a school-based water, sanitation, and hygiene program on absenteeism, diarrhea, and respiratory infection: a matched-control trial in Mali. Am J Trop Med Hyg 94: 14181425.[Crossref]
  9. Hamlin KL, Moss DM, Priest JW, Roberts J, Kubofcik J, Gass K, Streit TG, Nutman TB, Eberhard ML, Lammie PJ, , 2012. Longitudinal monitoring of the development of antifilarial antibodies and acquisition of Wuchereria bancrofti in a highly endemic area of Haiti. PLoS Negl Trop Dis 6: e1941.[Crossref]
  10. Lammie PJ, Weil G, Noordin R, Kaliraj P, Steel C, Goodman D, Lakshmikanthan VB, Ottesen E, , 2004. Recombinant antigen-based antibody assays for the diagnosis and surveillance of lymphatic filariasis: a multicenter trial. Filaria J 3: 9.[Crossref]
  11. Moss DM, Priest JW, Boyd A, Weinkopff T, Kucerova Z, Beach MJ, Lammie PJ, , 2011. Multiplex bead assay for serum samples from children in Haiti enrolled in a drug study for the treatment of lymphatic filariasis. Am J Trop Med Hyg 85: 229237.[Crossref]
  12. Goodhew EB, Priest JW, Moss DM, Zhong G, Munoz B, Mkocha H, Martin DL, West SK, Gaydos C, Lammie PJ, , 2012. CT694 and pgp3 as serological tools for monitoring trachoma programs. PLoS Negl Trop Dis 6: e1873.[Crossref]
  13. Moss DM, Priest JW, Hamlin K, Derado G, Herbein J, Petri WA, Jr Lammie PJ, , 2014. Longitudinal evaluation of enteric protozoa in Haitian children by stool exam and multiplex serologic assay. Am J Trop Med Hyg 90: 653660.[Crossref]
  14. Weil GJ, Ramzy RM, , 2007. Diagnostic tools for filariasis elimination programs. Trends Parasitol 23: 7882.[Crossref]
  15. Kubofcik J, Fink DL, Nutman TB, , 2012. Identification of Wb123 as an early and specific marker of Wuchereria bancrofti infection. PLoS Negl Trop Dis 6: e1930.[Crossref]
  16. Kellar KL, Kalwar RR, Dubois KA, Crouse D, Chafin WD, Kane BE, , 2001. Multiplexed fluorescent bead-based immunoassays for quantitation of human cytokines in serum and culture supernatants. Cytometry 45: 2736.[Crossref]
  17. Martins TB, Jaskowski TD, Tebo A, Hill HR, , 2009. Development of a multiplexed fluorescent immunoassay for the quantitation of antibody responses to four Neisseria meningitidis serogroups. J Immunol Methods 342: 98105.[Crossref]
  18. Pickering JW, Martins TB, Schroder MC, Hill HR, , 2002. Comparison of a multiplex flow cytometric assay with enzyme-linked immunosorbent assay for quantitation of antibodies to tetanus, diphtheria, and Haemophilus influenzae Type b. Clin Diagn Lab Immunol 9: 872876.
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  • Received : 07 Jul 2016
  • Accepted : 22 Sep 2016

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