1921
Volume 96, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Central nervous system involvement manifesting as meningitis or meningoencephalitis is a known complication of scrub typhus, but very few spinal cord lesions such as acute transverse myelitis (ATM) have been reported in association with this disease. Scrub typhus patients with a spinal lesion present with neurologic symptoms including dysuria, motor, and sensory weakness. Herein, we describe a rare case of ATM associated with scrub typhus. Clinical characteristics, cerebrospinal fluid cytology, serum antibody titer, and serial magnetic resonance imaging scans resulted in a diagnosis of ATM associated with scrub typhus.

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References

  1. Jeong YJ, Kim S, Wook YD, Lee JW, Kim KI, Lee SH, 2007. Scrub typhus: clinical, pathologic, and imaging findings. Radiographics 27: 161172.[Crossref]
    [Google Scholar]
  2. Kim DM, Kim SW, Choi SH, Yun NR, 2010. Clinical and laboratory findings associated with severe scrub typhus. BMC Infect Dis 10: 108.[Crossref]
    [Google Scholar]
  3. Varghese GM, Mathew A, Kumar S, Abraham OC, Trowbridge P, Mathai E, 2013. Differential diagnosis of scrub typhus meningitis from bacterial meningitis using clinical and laboratory features. Neurol India 61: 1720.[Crossref]
    [Google Scholar]
  4. Jamil MD, Hussain M, Lyngdoh M, Sharma S, Barman B, Bhattacharya PK, 2015. Scrub typhus meningoencephalitis, a diagnostic challenge for clinicians: a hospital based study from north-east India. J Neurosci Rural Pract 6: 488493.[Crossref]
    [Google Scholar]
  5. Kim JH, Lee SA, Ahn TB, Yoon SS, Park KC, Chang DI, Chung KC, 2008. Polyneuropathy and cerebral infarction complicating scrub typhus. J Clin Neurol 4: 3639.[Crossref]
    [Google Scholar]
  6. Pai H, Sohn S, Seong Y, Kee S, Chang WH, Choe KW, 1997. Central nervous system involvement in patients with scrub typhus. Clin Infect Dis 24: 436440.[Crossref]
    [Google Scholar]
  7. Lee KL, Lee JK, Yim YM, Lim OK, Bae KH, 2008. Acute transverse myelitis associated with scrub typhus: case report and a review of literatures. Diagn Microbiol Infect Dis 60: 237239.[Crossref]
    [Google Scholar]
  8. Mahajan SK, Kumar S, Garg M, Kaushik M, Sharma S, Raina R, 2016. Scrub typhus with longitudinally extensive transverse myelitis. J Vector Borne Dis 53: 8486.
    [Google Scholar]
  9. Transverse Myelitis Consortium Working Group, 2002. Proposed diagnostic criteria and nosology of acute transverse myelitis. Neurology 59: 499505.[Crossref]
    [Google Scholar]
  10. Jacob A, Weinshenker BG, 2008. An approach to the diagnosis of acute transverse myelitis. Semin Neurol 28: 105120.[Crossref]
    [Google Scholar]
  11. Kerr D, Krishnan C, Pidcock FS, Singer H, Kossoff E, Hartman A, Crawford T, 2005. Acute transverse myelitis. Singer HS, Kossoff EH, Hartman AL, Crawford TO, eds. Treatment of Pediatric Neurologic Disorders. Boca Raton, FL: Taylor and Francis Group.
    [Google Scholar]
  12. Lee CS, Hwang JH, 2015. Images in clinical medicine. Scrub typhus. N Engl J Med 373: 2455.[Crossref]
    [Google Scholar]
  13. Drevets DA, Leenen PJ, Greenfield RA, 2004. Invasion of the central nervous system by intracellular bacteria. Clin Microbiol Rev 17: 323347.[Crossref]
    [Google Scholar]
  14. Settle EB, Pinkerton H, Corbett AJ, 1945. A pathologic study of tsutsugamushi disease (scrub typhus) with notes on clinicopathologic correlation. J Lab Clin Med 30: 639661.
    [Google Scholar]
  15. Levine HD, 1946. Pathologic study of thirty-one cases of scrub typhus fever with especial reference to the cardiovascular system. Am Heart J 31: 314328.[Crossref]
    [Google Scholar]
  16. Kim DE, Lee SH, Park KI, Chang KH, Roh JK, 2000. Scrub typhus encephalomyelitis with prominent focal neurologic signs. Arch Neurol 57: 17701772.[Crossref]
    [Google Scholar]
  17. Hirono H, Yamadori A, Komiyama M, Yakura H, Yasui T, 1992. MRI of spontaneous spinal cord infarction: serial changes in gadolinium-DTPA enhancement. Neuroradiology 34: 9597.[Crossref]
    [Google Scholar]
  18. Friedman DP, Tartaglino LM, Fisher AR, Flanders AE, 1995. MR imaging in the diagnosis of intramedullary spinal cord diseases that involve specific neural pathways or vascular territories. Am J Roentgenol 165: 515523.[Crossref]
    [Google Scholar]
  19. Mawad ME, Rivera V, Crawford S, Ramirez A, Breitbach W, 1990. Spinal cord ischemia after resection of thoracoabdominal aortic aneurysms: MR findings in 24 patients. Am J Roentgenol 155: 13031307.[Crossref]
    [Google Scholar]
  20. Kincaid O, Lipton HL, 2006. Viral myelitis: an update. Curr Neurol Neurosci Rep 6: 469474.[Crossref]
    [Google Scholar]
  21. Hughes RA, Cornblath DR, 2005. Guillain-Barre syndrome. Lancet 366: 16531666.[Crossref]
    [Google Scholar]
  22. Willison HJ, Jacobs BC, van Doorn PA, 2016. Guillain-Barre syndrome. Lancet 388: 717727.[Crossref]
    [Google Scholar]
  23. Lee SH, Jung SI, Park KH, Choi SM, Park MS, Kim BC, Kim MK, Cho KH, 2007. Guillain-Barre syndrome associated with scrub typhus. Scand J Infect Dis 39: 826828.[Crossref]
    [Google Scholar]
  24. Byun WM, Park WK, Park BH, Ahn SH, Hwang MS, Chang JC, 1998. Guillain-Barre syndrome: MR imaging findings of the spine in eight patients. Radiology 208: 137141.[Crossref]
    [Google Scholar]
  25. Lee CS, Hwang JH, Lee HB, Kwon KS, 2009. Risk factors leading to fatal outcome in scrub typhus patients. Am J Trop Med Hyg 81: 484488.[Crossref]
    [Google Scholar]
  26. Kim DM, Chung JH, Yun NR, Kim SW, Lee JY, Han MA, Lee YB, 2013. Scrub typhus meningitis or meningoencephalitis. Am J Trop Med Hyg 89: 12061211.[Crossref]
    [Google Scholar]
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  • Received : 27 Jun 2016
  • Accepted : 04 Dec 2016
  • Published online : 23 Jan 2017
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