1921
Volume 95, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Emerging artemisinin resistance is a threat to global malaria control. Mutations in the Kelch 13 () propeller domain confer artemisinin resistance and constitute molecular markers for its detection and monitoring. We sequenced 222 isolates obtained from community children in the Huye District of southern Rwanda in 2010, 2014, and 2015 to investigate the presence of polymorphisms. No polymorphisms were observed in 2010 but they were present in 2.5% and 4.5% in 2014 and 2015, respectively. In 2015, two isolates showed candidate resistance mutations (P574L and A675V), which are common in southeast Asia and associated with delayed parasite clearance. polymorphisms in southern Rwanda are infrequent but include variants associated with artemisinin resistance. Establishing correlations with local treatment response and in vitro resistance assays are needed in addition to further monitoring polymorphisms in the study area.

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/content/journals/10.4269/ajtmh.16-0483
2016-11-02
2017-09-24
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  • Received : 15 Jun 2016
  • Accepted : 22 Jul 2016

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