Volume 95, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Praziquantel is the mainstay of treatment of Schistosomiasis, which affects at least 262 million people worldwide. It is also used in the treatment of other trematode as well as cestode infections, with few safe and effective alternatives. It is generally well tolerated and allergic reactions are rare. In this report, we present a case of schistosomiasis with a history of a hypersensitivity reaction to praziquantel. Skin-prick and intradermal testing were performed, followed by treatment through rapid desensitization. This protocol may be of value to those patients requiring praziquantel treatment with a history of IgE-mediated allergy to the drug.


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  1. Bustinduy AL, King CH, Farrar J, , 2013 Schistosomiasis. , ed. Manson's Tropical Diseases. Philadelphia, PA: Saunders.
  2. Burke ML, Jones MK, Gobert GN, Li YS, Ellis MK, McManus DP, , 2009. Immunopathogenesis of human schistosomiasis. Parasite Immunol 31: 163176.[Crossref]
  3. Colley DG, Bustinduy AL, Secor WE, King CH, , 2014. Human schistosomiasis. Lancet 383: 22532264.[Crossref]
  4. Andrews P, Thomas H, Pohlke R, Seubert J, , 1983. Praziquantel. Med Res Rev 3: 147200.[Crossref]
  5. Coulibaly JT, N'Gbesso YK, Knopp S, Keiser J, N'Goran EK, Utzinger J, , 2012. Efficacy and safety of praziquantel in preschool-aged children in an area co-endemic for Schistosoma mansoni and S. haematobium . PLoS Negl Trop Dis 6: e1917.[Crossref]
  6. Foster R, , 1987. A review of clinical experience with oxamniquine. Trans R Soc Trop Med Hyg 81: 5559.[Crossref]
  7. Perez del Villar L, Burguillo FJ, Lopez-Aban J, Muro A, , 2012. Systematic review and meta-analysis of artemisinin based therapies for the treatment and prevention of schistosomiasis. PLoS One 7: e45867.[Crossref]
  8. Kyung SY, Cho YK, Kim YJ, Park JW, Jeong SH, Lee JI, Sung YM, Lee SP, , 2011. A paragonimiasis patient with allergic reaction to praziquantel and resistance to triclabendazole: successful treatment after desensitization to praziquantel. Korean J Parasitol 49: 7377.[Crossref]
  9. Lee JM, Lim HS, Hong ST, , 2011. Hypersensitive reaction to praziquantel in a clonorchiasis patient. Korean J Parasitol 49: 273275.[Crossref]
  10. Shen C, Choi MH, Bae YM, Yu G, Wang S, Hong ST, , 2007. A case of anaphylactic reaction to praziquantel treatment. Am J Trop Med Hyg 76: 603605.
  11. Huang SW, , 1992. A clinical approach to a patient with praziquantel hypersensitivity. J Allergy Clin Immunol 90: 867.[Crossref]
  12. Liu T, , 1984. Allergic manifestation after pyquiton treatment of schistosomiasis [in Chinese]. Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2: 203.
  13. Kramer CV, Zhang F, Sinclair D, Olliaro PL, , 2014. Drugs for treating urinary schistosomiasis. Cochrane Database Syst Rev 8: CD000053.
  14. Demoly P, Bousquet J, , 2002. Drug allergy diagnosis work up. Allergy 57 (Suppl 72): 3740.[Crossref]
  15. Satti MZ, Cahen P, Skov PS, Joseph S, Jones FM, Fitzsimmons C, Hoffmann KF, Reimert C, Kariuki HC, Kazibwe F, Mwatha JK, Kimani G, Vennervald BJ, Ouma JH, Kabatereine NB, Dunne DW, , 2004. Changes in IgE- and antigen-dependent histamine-release in peripheral blood of Schistosoma mansoni-infected Ugandan fishermen after treatment with praziquantel. BMC Immunol 5: 6.[Crossref]
  16. Chai JY, , 2013. Praziquantel treatment in trematode and cestode infections: an update. Infect Chemother 45: 3243.[Crossref]
  17. Soyer OU, Aytac S, Tuncer A, Cetin M, Yetgin S, Sekerel BE, , 2009. Alternative algorithm for L-asparaginase allergy in children with acute lymphoblastic leukaemia. J Allergy Clin Immunol 123: 895899.[Crossref]
  18. Castells MC, Tennant NM, Sloane DE, Hsu FI, Barrett NA, Hong DI, Laidlaw TM, Legere HJ, Nallamshetty SN, Palis RI, Rao JJ, Berlin ST, Campos SM, Matulonis UA, , 2008. Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases. J Allergy Clin Immunol 122: 574580.[Crossref]
  19. Castells M, Sancho-Serra MC, Simarro M, , 2012. Hypersensitivity to antineoplastic agents: mechanisms and treatment with rapid desensitization. Cancer Immunol Immunother 61: 15751584.[Crossref]

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  • Received : 09 Jun 2016
  • Accepted : 07 Jul 2016

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