Volume 95, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Data on the burden and incidence of endemic Burkitt lymphoma (eBL) across Mozambique are scarce. We retrospectively retrieved information on eBL cases from reports of the three main hospitals of Mozambique: Maputo Central Hospital (MCH), Beira Central Hospital (BCH), and Nampula Central Hospital (NCH) between 2004 and 2014. For 2015, we prospectively collected information of new eBL cases attending these hospitals. A total of 512 eBL cases were reported between 2004 and 2015: 153 eBL cases were reported in MCH, 195 in BCH, and 164 in NCH. Mean age of cases was 6.9 years (standard deviation = 2.8); 63% (319/504) of cases were males. For 2015, the estimated incidence rate of eBL was 2.0, 1.7, and 3.9 per 10 person-year at risk in MCH, BCH, and NCH, respectively. Incidence was higher in NCH (northern Mozambique), where intensity of malaria transmission is higher. Data presented show that eBL is a common pediatric malignancy in Mozambique, as observed in neighboring countries.


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  1. Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S, , 2012. Burkitt's lymphoma. Lancet 379: 12341244.[Crossref]
  2. Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V, , 2009. A review of human carcinogens: Part B: biological agents. Lancet Oncol 10: 321322. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19350698. Accessed June 6, 2013.[Crossref]
  3. Carpenter LM, Newton R, Casabonne D, Ziegler J, Mbulaiteye S, Mbidde E, Wabinga H, Jaffe H, Beral V, , 2008. Antibodies against malaria and Epstein-Barr virus in childhood Burkitt lymphoma: a case-control study in Uganda. Int J Cancer 122: 13191323.[Crossref]
  4. Mutalima N, Molyneux E, Jaffe H, Kamiza S, Borgstein E, Mkandawire N, Liomba G, Batumba M, Lagos D, Gratrix F, Boshoff C, Casabonne D, Carpenter LM, Newton R, , 2008. Associations between Burkitt lymphoma among children in Malawi and infection with HIV, EBV and malaria: results from a case-control study. PLoS One 3: e2505.[Crossref]
  5. Aka P, Vila MC, Jariwala A, Nkrumah F, Emmanuel B, Yagi M, Palacpac NM, Periago MV, Neequaye J, Kiruthu C, Tougan T, Levine PH, Biggar RJ, Pfeiffer RM, Bhatia K, Horii T, Bethony JM, Mbulaiteye SM, , 2013. Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. Blood 122: 629635.[Crossref]
  6. Piriou E, Kimmel R, Chelimo K, Middeldorp JM, Sumba P, Ploutz-snyder R, Moormann AM, Rochford R, , 2009. Serological evidence for long-term Epstein–Barr virus reactivation in children living in a holoendemic malaria region of Kenya. J Med Virol 81: 10881093.[Crossref]
  7. Asito AS, Piriou E, Odada PS, Fiore N, Middeldorp JM, Long C, Dutta S, Lanar DE, Jura WG, Ouma C, Otieno JA, Moormann AM, Rochford R, , 2010. Elevated anti-Zta IgG levels and EBV viral load are associated with site of tumor presentation in endemic Burkitt's lymphoma patients: a case control study. Infect Agent Cancer 5: 13.[Crossref]
  8. Johnston WT, Mutalima N, Sun D, Emmanuel B, Bhatia K, Aka P, Wu X, Borgstein E, Liomba GN, Kamiza S, Mkandawire N, Batumba M, Carpenter LM, Jaffe H, Molyneux EM, Goedert JJ, Soppet D, Newton R, Mbulaiteye SM, , 2014. Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi. Sci Rep 4: 3741.[Crossref]
  9. Bouvard V, Baan RA, Grosse Y, Lauby-Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Straif K, WHO International Agency for Research on Cancer Monograph Working Group; , 2012. Carcinogenicity of malaria and of some polyomaviruses. Lancet Oncol 13: 339340.[Crossref]
  10. Bhatt S, Weiss DJ, Cameron E, Bisanzio D, Mappin B, Dalrymple U, Battle KE, Moyes CL, Henry A, Eckhoff PA, Wenger EA, Briët O, Penny MA, Smith TA, Bennett A, Yukich J, Eisele TP, Griffin JT, Fergus CA, Lynch M, Lindgren F, Cohen JM, Murray CL, Smith DL, Hay SI, Cibulskis RE, Gething PW, , 2015. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature 526: 207211.[Crossref]
  11. Ministerio da Saude (MISAU), Instituto Nacional de Estatística (INE), ICF International (ICFI), 2013. Moçambique Inquérito Demográfico E de Saúde 2011. Calverton, MD. Available at: http://dhsprogram.com/pubs/pdf/FR266/FR266.pdf. Accessed March 6, 2016.
  12. Carreira H, Lorenzoni C, Carrilho C, Ferro J, Sultane T, Garcia C, Amod F, Augusto O, Silva-Matos C, La Vecchia C, Lunet N, , 2014. Spectrum of pediatric cancers in Mozambique: an analysis of hospital and population-based data. Pediatr Hematol Oncol 31: 498508.[Crossref]
  13. Msyamboza KP, Dzamalala C, Mdokwe C, Kamiza S, Lemerani M, Dzowela T, Kathyola D, , 2012. Burden of cancer in Malawi; common types, incidence and trends: national population-based cancer registry. BMC Res Notes 5: 149.[Crossref]
  14. Stefan DC, , 2015. Patterns of distribution of childhood cancer in Africa. J Trop Pediatr 61: 165173.[Crossref]
  15. Insituto Nacional de Estadística (Moçambique), 2007. Projeções anuais da população total, urbana e rural, 2007–2040. Available at: http://www.ine.gov.mz/estatisticas/estatisticas-demograficas-e-indicadores-sociais/populacao/projeccoes-da-populacao. Accessed October 8, 2015.
  16. Department of Zoology–University of Oxford, 2015. Malaria Atlas Project (MAP). Available at: http://www.map.ox.ac.uk/. Accessed May 2, 2016.
  17. Aka P, Kawira E, Masalu N, Emmanuel B, Brubaker G, Magatti J, Mbulaiteye SM, , 2012. Incidence and trends in Burkitt lymphoma in northern Tanzania from 2000 to 2009. Pediatr Blood Cancer 59: 12341238.[Crossref]
  18. Rainey JJ, Omenah D, Sumba PO, Moormann AM, Rochford R, Wilson ML, , 2007. Spatial clustering of endemic Burkitt's lymphoma in high-risk regions of Kenya. Int J Cancer 120: 121127.[Crossref]
  19. Ogwang MD, Bhatia K, Biggar RJ, Mbulaiteye SM, , 2008. Incidence and geographic distribution of endemic Burkitt lymphoma in northern Uganda revisited. Int J Cancer 123: 26582663.[Crossref]
  20. Sacarlal J, Nhacolo AQ, Sigaúque B, Nhalungo DA, Abacassamo F, Sacoor CN, Aide P, Machevo S, Nhampossa T, Macete EV, Bassat Q, David C, Bardají A, Letang E, Saúte F, Aponte JJ, Thompson R, Alonso PLA, , 2009. 10 year study of the cause of death in children under 15 years in Manhiça, Mozambique. BMC Public Health 9: 67.[Crossref]

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  • Received : 25 May 2016
  • Accepted : 20 Aug 2016

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