Volume 96, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We describe the case of a 43-year-old human immunodeficiency virus–infected man receiving combined antiretroviral therapy and coinfected with , , and , presenting as chronic diarrhea and critical weight loss. Immunological aspects of these interactions are reviewed.


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  1. Sarfo FS, Sarfo MA, Norman B, Phillips R, Bedu-Addo G, Chadwick D, , 2014. Risk of deaths, AIDS-defining and non-AIDS defining events among Ghanaians on long-term combination antiretroviral therapy. PLoS One 9: e111400.[Crossref] [Google Scholar]
  2. Adamu H, Petros B, Zhang G, Kassa H, Amer S, Ye J, Feng Y, Xiao L, , 2014. Distribution and clinical manifestations of Cryptosporidium species and subtypes in HIV/AIDS patients in Ethiopia. PLoS Negl Trop Dis 8: e2831.[Crossref] [Google Scholar]
  3. Lewthwaite P, Gill GV, Hart CA, Beeching NJ, , 2005. Gastrointestinal parasites in the immunocompromised. Curr Opin Infect Dis 18: 427435.[Crossref] [Google Scholar]
  4. Ash LR, Orihel TC, Salvioli L, , 1994. Bench Aids for the Diagnosis of Intestinal Parasites. Geneva, Switzerland: World Health Organization. [Google Scholar]
  5. Ito A, , 2015. Basic and applied problems in developmental biology and immunobiology of cestode infections: Hymenolepis, Taenia and Echinococcus . Parasite Immunol 37: 5369.[Crossref] [Google Scholar]
  6. Ito A, , 2015. Beyond our conceived concepts. Parasite Immunol 37: 430431.[Crossref] [Google Scholar]
  7. Devera R, Blanco Y, Amaya I, Requena I, Tedesco RM, Alevante C, Chibli A, , 2012. Prevalencia de Giardia intestinalis en habitantes del Barrio La Macarena, Ciudad Bolívar, Venezuela. Gen 66: 243249. [Google Scholar]
  8. Boaitey YA, Nkrumah B, Idriss A, Tay SC, , 2012. Gastrointestinal and urinary tract pathogenic infections among HIV seropositive patients at the Komfo Anokye Teaching Hospital in Ghana. BMC Res Notes 5: 454.[Crossref] [Google Scholar]
  9. Adamu H, Wegayehu T, Petros B, , 2013. High prevalence of diarrhoegenic intestinal parasite infections among non-ART HIV patients in Fitche Hospital, Ethiopia. PLoS One 8: e72634.[Crossref] [Google Scholar]
  10. Escobedo AA, Almirall P, Alfonso M, Cimerman S, Chacín-Bonilla L, , 2014. Sexual transmission of giardiasis: a neglected route of spread? Acta Trop 132: 106111.[Crossref] [Google Scholar]
  11. Anuar TS, Al-Mekhlafi HM, Ghani MK, Osman E, Yasin AM, Nordin A, Azreen SN, Salleh FM, Ghazali N, Bernadus M, Moktar N, , 2012. Giardiasis among different tribes of Orang Asli in Malaysia: highlighting the presence of other family members infected with Giardia intestinalis as a main risk factor. Int J Parasitol 42: 871880.[Crossref] [Google Scholar]
  12. Saghaug CS, Sørnes S, Peirasmaki D, Svärd S, Langeland N, Hanevik K, , 2015. Human memory CD4+ T cell immune responses against Giardia lamblia . Clin Vaccine Immunol 23: 1118.[Crossref] [Google Scholar]
  13. Gonçalves AC, Gabbay YB, Mascarenhas JD, Yassaka MB, Moran LC, Fraga VD, Castro E, Franco C, Machado RL, Rossit AR, , 2009. Calicivirus and Giardia lamblia are associated with diarrhea in human immunodeficiency virus-seropositive patients from southeast Brazil. Am J Trop Med Hyg 81: 463466. [Google Scholar]
  14. Korn T, Bettelli E, Oukka M, Kuchroo VK, , 2009. IL-17 and Th17 Cells. Annu Rev Immunol 27: 485517.[Crossref] [Google Scholar]
  15. Blaschitz C, Raffatellu M, , 2010. Th17 cytokines and the gut mucosal barrier. J Clin Immunol 30: 196203.[Crossref] [Google Scholar]
  16. Falivene J, Ghiglione Y, Laufer N, Socías ME, Holgado MP, Ruiz MJ, Maeto C, Figueroa MI, Giavedoni LD, Cahn P, Salomón H, Sued O, Turk G, Gherardi MM, , 2015. Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8(+) T-cell responses and disease progression. Sci Rep 5: 11511.[Crossref] [Google Scholar]
  17. Kim CJ, McKinnon LR, Kovacs C, Kandel G, Huibner S, Chege D, Shahabi K, Benko E, Loutfy M, Ostrowski M, Kaul R, , 2013. Mucosal Th17 cell function is altered during HIV infection and is an independent predictor of systemic immune activation. J Immunol 191: 21642173.[Crossref] [Google Scholar]
  18. Solaymani-Mohammadi S, Singer SM, , 2010. Giardia duodenalis. The double-edged sword of immune responses in giardiasis. Exp Parasitol 126: 292297.[Crossref] [Google Scholar]
  19. von Allmen N, Christen S, Forster U, Gottstein B, Welle M, Müller N, , 2006. Acute trichinellosis increases susceptibility to Giardia lamblia infections in the mouse model. Parasitology 133: 139149.[Crossref] [Google Scholar]
  20. Hagel I, Cabrera M, Puccio F, Santaella C, Buvat E, Infante B, Zabala M, Cordero R, Di Prisco MC, , 2011. Co-infection with Ascaris lumbricoides modulates protective immune responses against Giardia duodenalis in school Venezuelan rural children. Acta Trop 117: 189195.[Crossref] [Google Scholar]

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  • Received : 20 May 2016
  • Accepted : 04 Jan 2017
  • Published online : 20 Feb 2017

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