1921
Volume 96, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Orbital biopsy of nonspecific orbital inflammation, commonly referred to as “orbital pseudotumor,” typically shows a combination of polyclonal lymphocytes, plasmocytes, leukocytes, macrophages, and variable degrees of collagen deposition. Herein, we report a patient with a positive history of mucocutaneous leishmaniasis who presented with an orbital mass with a histological profile of idiopathic orbital inflammation. Immunohistochemical and molecular analysis of the orbital specimens demonstrated that the orbital inflammation was associated with the presence of antigens of and DNA from the parasite.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.16-0389
2017-01-11
2019-11-21
Loading full text...

Full text loading...

/deliver/fulltext/14761645/96/1/197.html?itemId=/content/journals/10.4269/ajtmh.16-0389&mimeType=html&fmt=ahah

References

  1. Grove AS, Jr Weber AL, , 2013. Orbital pseudotumor: historical origin and modern relevance. Ophthal Plast Reconstr Surg 29: 341346.[Crossref] [Google Scholar]
  2. Mombaerts I, Goldschmeding R, Schlingemann RO, Koornneef L, , 1996. What is orbital pseudotumor? Surv Ophthalmol 41: 6678.[Crossref] [Google Scholar]
  3. Gibson LJ, McCann SH, Brewster S, Barker DC, , 2002. A kinetoplast DNA minicircle probe (B18) specific for the Leishmania subgenus Viannia . Trans R Soc Trop Med Hyg 96 (Suppl 1): S71S73.[Crossref] [Google Scholar]
  4. de Lima AC, Zampieri RA, Tomokane TY, Laurenti MD, Silveira FT, Corbett CE, Floeter-Winter LM, Gomes CM, , 2011. Leishmania sp. identification by PCR associated with sequencing of target SSU rDNA in paraffin-embedded skin samples stored for more than 30 years. Parasitol Res 108: 15251531.[Crossref] [Google Scholar]
  5. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ, , 1990. Basic local alignment search tool. J Mol Biol 215: 403410.[Crossref] [Google Scholar]
  6. Harris GJ, , 2006. Idiopathic orbital inflammation: a pathogenetic construct and treatment strategy: the 2005 ASOPRS Foundation Lecture. Ophthal Plast Reconstr Surg 22: 7986.[Crossref] [Google Scholar]
  7. David CV, Craft N, , 2009. Cutaneous and mucocutaneous leishmaniasis. Dermatol Ther (Heidelb) 22: 491502.[Crossref] [Google Scholar]
  8. Alves-Ferreira EV, Toledo JS, De Oliveira AH, Ferreira TR, Ruy PC, Pinzan CF, Santos RF, Boaventura V, Rojo D, López-Gonzálvez Á, Rosa JC, Barbas C, Barral-Netto M, Barral A, Cruz AK, , 2015. Differential gene expression and infection profiles of cutaneous and mucosal Leishmania braziliensis isolates from the same patient. PLoS Negl Trop Dis 9: e0004018.[Crossref] [Google Scholar]
  9. Huna-Baron R, Warren FA, Miller W, Jacobs J, Green J, Kupersmith MJ, , 2000. Mucosal leishmaniasis presenting as sinusitis and optic neuropathy. Arch Ophthalmol 118: 852854. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.16-0389
Loading
/content/journals/10.4269/ajtmh.16-0389
Loading

Data & Media loading...

Supplemental File

  • Received : 16 May 2016
  • Accepted : 11 Sep 2016
  • Published online : 11 Jan 2017

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error