Volume 96, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The first human infection with severe fever with thrombocytopenia syndrome virus (SFTSV) was detected in Shaanxi Province, China, in 2013, although the virus had been reported in 13 other provinces of China since 2010. We collected and analyzed a total of 4,011 samples, including 936 human serum samples, 155 animal serum samples, 895 ticks, 1,950 mosquitoes, 30 midges, and 20 sandflies. SFTSV antibodies were found in 44 human samples (4.7%) with no significant differences between males and females or across counties. The incidence rate of severe fever with thrombocytopenia syndrome was significantly higher among individuals 20–60 years of age. Moreover, SFTSV-specific antibodies were detected in goats (66.7%), cattle (13.2%), and dogs (15.0%), but not in pigs (0%). We detected the virus in ticks with a prevalence rate of 21.3% (17/80 pools). All mosquito, midge, and sandfly samples were negative for SFTSV. These results support wide circulation of the virus in western China. ticks may serve as a novel SFTSV vector, and the role of these ticks requires further investigation.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Xu B, Liu L, Huang X, Ma H, Zhang Y, Du Y, Wang P, Tang X, Wang H, Kang K, Zhang S, Zhao G, Wu W, Yang Y, Chen H, Mu F, Chen W, , 2011. Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus. PLoS Pathog 7: e1002369.[Crossref] [Google Scholar]
  2. Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang LH, Zhang QF, Popov VL, Li C, Qu J, Li Q, Zhang Y, Hai R, Wu W, Wang Q, Zhan F, Wang X, Kan B, Wang S, Wan K, Jing H, Lu J, Yin W, Zhou H, Guan X, Liu J, Bi Z, Liu G, Ren J, Wang H, Zhao Z, Song JD, He JR, Wan T, Zhang JS, Fu XP, Sun LN, Dong XP, Feng ZJ, Yang WZ, Hong T, Zhang Y, Walker DH, Wang Y, Li DX, , 2011. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364: 15231532.[Crossref] [Google Scholar]
  3. Wang S, Li J, Niu G, Wang X, Ding S, Jiang X, Li C, Zhang Q, Liang M, Bi Z, Li D, , 2015. SFTS virus in ticks in an endemic area of China. Am J Trop Med Hyg 92: 684689.[Crossref] [Google Scholar]
  4. Bao C, Guo X, Qi X, Hu J, Zhou M, Varma JK, Cui L, Yang H, Jiao Y, Klena JD, Li LX, Tao WY, Li X, Chen Y, Zhu Z, Xu K, Shen AH, Wu T, Peng HY, Li ZF, Shan J, Shi ZY, Wang H, , 2011. A family cluster of infections by a newly recognized Bunyavirus in eastern China, 2007: further evidence of person-to-person transmission. Clin Infect Dis 53: 12081214.[Crossref] [Google Scholar]
  5. Niu G, Li J, Liang M, Jiang X, Jiang M, Yin H, Wang Z, Li C, Zhang Q, Jin C, Wang X, Ding S, Xing Z, Wang S, Bi Z, Li D, , 2013. Severe fever with thrombocytopenia syndrome virus among domesticated animals, China. Emerg Infect Dis 19: 185189.[Crossref] [Google Scholar]
  6. Liu Q, He B, Huang S, Wei F, Zhu X, , 2014. Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis. Lancet Infect Dis 14: 763772.[Crossref] [Google Scholar]
  7. Hu C, Guo C, Yang Z, Wang L, Hu J, Qin S, Cui N, Peng W, Liu K, Liu W, Cao W, , 2015. The severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) antibody in a highly endemic region from 2011 to 2013: a comparative serological study. Am J Trop Med Hyg 92: 479481.[Crossref] [Google Scholar]
  8. Zhang Y, Zou Y, Fu Z, Plyusnin A, , 2010. Hantavirus infections in humans and animals, China. Emerg Infect Dis 16: 11951203.[Crossref] [Google Scholar]
  9. Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, Kamei T, Honda M, Ninomiya D, Sakai T, Senba T, Kaneyuki S, Sakaguchi S, Satoh A, Hosokawa T, Kawabe Y, Kurihara S, Izumikawa K, Kohno S, Azuma T, Suemori K, Yasukawa M, Mizutani T, Omatsu T, Katayama Y, Miyahara M, Ijuin M, Doi K, Okuda M, Umeki K, Saito T, Fukushima K, Nakajima K, Yoshikawa T, Tani H, Fukushi S, Fukuma A, Ogata M, Shimojima M, Nakajima N, Nagata N, Katano H, Fukumoto H, Sato Y, Hasegawa H, Yamagishi T, Oishi K, Kurane I, Morikawa S, Saijo M, , 2014. The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 209: 816827.[Crossref] [Google Scholar]
  10. Kim KH, Yi J, Kim G, Choi SJ, Jun KI, Kim NH, Choe PG, Kim NJ, Lee JK, Oh MD, , 2013. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis 19: 18921894.[Crossref] [Google Scholar]
  11. Wei J, Li S, Dong J, Tian H, Chowell G, Tian H, Lv W, Han Z, Xu B, Yu P, , 2015. The first human infection with severe fever with thrombocytopenia syndrome virus in Shaanxi Province, China. Int J Infect Dis 35: 3739.[Crossref] [Google Scholar]
  12. Sun Y, Liang M, Qu J, Jin C, Zhang Q, Li J, Jiang X, Wang Q, Lu J, Gu W, Zhang S, Li C, Wang X, Zhan F, Yao W, Bi Z, Wang S, Li D, , 2012. Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay. J Clin Virol 53: 4853.[Crossref] [Google Scholar]
  13. Yun SM, Lee WG, Ryou J, Yang SC, Park SW, Roh JY, Lee YJ, Park C, Han MG, , 2014. Severe fever with thrombocytopenia syndrome virus in ticks collected from humans, South Korea, 2013. Emerg Infect Dis 20: 13581361.[Crossref] [Google Scholar]
  14. Meng K, Sun W, Cheng Z, Guo H, Liu J, Chai T, , 2015. First detection of severe fever with thrombocytopenia syndrome virus in the tick species Haemaphysalis concinna in Shandong Province, China. Parasitol Res 114: 47034707.[Crossref] [Google Scholar]
  15. Depaquit J, Grandadam M, Fouque F, Andry P, Peyrefitte C, , 2010. Arthropod-borne viruses transmitted by phlebotomine sandflies in Europe: a review. Euro Surveill 15: 19507. [Google Scholar]
  16. Cui F, Cao HX, Wang L, Zhang SF, Ding SJ, Yu XJ, Yu H, , 2013. Clinical and epidemiological study on severe fever with thrombocytopenia syndrome in Yiyuan County, Shandong Province, China. Am J Trop Med Hyg 88: 510512.[Crossref] [Google Scholar]
  17. Zhao L, Zhai S, Wen H, Cui F, Chi Y, Wang L, Xue F, Wang Q, Wang Z, Zhang S, Song Y, Du J, Yu X, , 2012. Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis 18: 963965.[Crossref] [Google Scholar]
  18. Zhang WS, Zeng XY, Zhou MH, Jiao YJ, Wen T, Guo XL, Shi ZY, , 2011. Seroepidemiology of severe fever with thrombocytopeia syndrome bunyavirus in Jiansu Province [in Chinese]. Dis Surveill 26: 676678. [Google Scholar]
  19. Liu L, Guan X, Xing X, Shen X, Xu J, Yue J, Huo X, Sha S, Wu H, Huang J, , 2012. Epidemiologic analysis on severe fever with thrombocytopenia syndrome in Hubei province, 2010 [in Chinese]. Chin J Endemiology 33: 168172. [Google Scholar]
  20. Liang S, Bao C, Zhou M, Hu J, Tang F, Guo X, Jiao Y, Zhang W, Luo P, Li L, Zhu K, Tan W, Lu Q, Ge H, Chen A, , 2014. Seroprevalence and risk factors for severe fever with thrombocytopenia syndrome virus infection in Jiangsu Province, China, 2011. Am J Trop Med Hyg 90: 256259.[Crossref] [Google Scholar]

Data & Media loading...

Supplemental Information

  • Received : 27 Apr 2016
  • Accepted : 08 Sep 2016
  • Published online : 10 Apr 2017

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error