1921
Volume 97, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Little is known about the specific causes of neonatal and under-five childhood death in high-mortality geographic regions due to a lack of primary data and dependence on inaccurate tools, such as verbal autopsy. To meet the ambitious new Sustainable Development Goal 3.2 to eliminate preventable child mortality in every country, better approaches are needed to precisely determine specific causes of death so that prevention and treatment interventions can be strengthened and focused. Minimally invasive tissue sampling (MITS) is a technique that uses needle-based postmortem sampling, followed by advanced histopathology and microbiology to definitely determine cause of death. The Bill & Melinda Gates Foundation is supporting a new surveillance system called the Child Health and Mortality Prevention Surveillance network, which will determine cause of death using MITS in combination with other information, and yield cause-specific population-based mortality rates, eventually in up to 12–15 sites in sub-Saharan Africa and south Asia. However, the Gates Foundation funding alone is not enough. We call on governments, other funders, and international stakeholders to expand the use of pathology-based cause of death determination to provide the information needed to end preventable childhood mortality.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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2017-07-12
2017-09-21
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References

  1. GBD 2015 Child Mortality Collaborators, 2016. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388: 17251774.[Crossref]
  2. World Health Organization, 2009. State of the World's Vaccines and Immunization, 3rd edition. Geneva, Switzerland: World Health Organization.
  3. You D, Hug L, Ejdemyr S, Idele P, Hogan D, Mathers C, Gerland P, New JR, Alkema L, , 2015. Global, regional, and national levels and trends in under-5 mortality between 1990 and 2015, with scenario-based projections to 2030: a systematic analysis by the UN Inter-agency Group for Child Mortality Estimation. Lancet 386: 22752286.[Crossref]
  4. Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, Lawn JE, Cousens S, Mathers C, Black RE, , 2016. Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet 388: 30273035.[Crossref]
  5. Murray CJL, Lozano R, Flaxman AD, Serina P, Phillips D, Stewart A, James SL, Vahdatpour A, Atkinson C, Freeman MK, Ohno SL, Black R, Ali SM, Baqui AH, Dandona L, Dantzer E, Darmstadt GL, Das V, Dhingra U, Dutta A, Fawzi W, Gómez S, Hernández B, Joshi R, Kalter HD, Kumar A, Kumar V, Lucero M, Mehta S, Neal B, Praveen D, Premji Z, Ramírez-Villalobos D, Remolador H, Riley I, Romero M, Said M, Sanvictores D, Sazawal S, Tallo V, Lopez AD, , 2014. Using verbal autopsy to measure causes of death: the comparative performance of existing methods. BMC Med 12: 5.[Crossref]
  6. Fligner CL, Murray J, Roberts DJ, , 2011. Synergism of verbal autopsy and diagnostic pathology autopsy for improved accuracy of mortality data. Popul Health Metr 9: 25.[Crossref]
  7. Institute for Health Metrics and Evaluation, 2016. Causes of Death (COD) Data Visualization. Seattle, WA: Institute for Health Metrics and Evaluation, University of Washington.
  8. United Nations, 2017. Sustainable Development Goals: 17 Goals to Transform Our World. Available at: http://www.un.org/sustainabledevelopment/. Accessed February 7, 2017.
  9. Maixenchs M, Anselmo R, Zielinski-Gutiérrez E, Odhiambo FO, Akello C, Ondire M, Zaidi SSH, Soofi SB, Bhutta ZA, Diarra K, Djitèye M, Dembélé R, Sow S, Minsoko PCA, Agnandji ST, Lell B, Ismail MR, Carrilho C, Ordi J, Menéndez C, Bassat Q, Munguambe K, , 2016. Willingness to know the cause of death and hypothetical acceptability of the minimally invasive autopsy in six diverse African and Asian settings: a mixed methods socio-behavioural study. PLoS Med 13: e1002172.[Crossref]
  10. Blokker BM, Wagensveld IM, Weustink AC, Oosterhuis JW, Hunink MGM, , 2015. Non-invasive or minimally invasive autopsy compared to conventional autopsy of suspected natural deaths in adults: a systematic review. Eur Radiol 26: 11591179.[Crossref]
  11. Castillo P, Martínez MJ, Ussene E, Jordao D, Lovane L, Ismail MR, Carrilho C, Lorenzoni C, Fernandes F, Bene R, Palhares A, Ferreira L, Lacerda M, Mandomando I, Vila J, Hurtado JC, Munguambe K, Maixenchs M, Sanz A, Quintó L, Macete E, Alonso P, Bassat Q, Menéndez C, Ordi J, , 2016. Validity of a minimally invasive autopsy for cause of death determination in adults in Mozambique: an observational study. PLoS Med 13: e1002171.[Crossref]
  12. Munguambe K, , 2015. Feasibility and Acceptability of Procedures to Determine Cause of Death: Preliminary Results from the CaDMIA Multicentre Study. The 9th European Congress on Tropical Medicine and International Health, September 6–10, 2015, Basel, Switzerland.
  13. Bassat Q, Ordi J, Vila J, Ismail MR, Carrilho C, Lacerda M, Munguambe K, Odhiambo F, Lell B, Sow S, Bhutta ZA, Rabinovich NR, Alonso PL, Menéndez C, , 2013. Development of a post-mortem procedure to reduce the uncertainty regarding causes of death in developing countries. Lancet Glob Health 1: 125126.[Crossref]
  14. Jha P, Gajalakshmi V, Gupta PC, Kumar R, Mony P, Dhingra N, Peto R, , 2006. Prospective study of one million deaths in India: rationale, design, and validation results. PLoS Med 3: e18.[Crossref]
  15. Dowell SF, Blazes D, Desmond-Hellmann S, , 2016. Four steps to precision public health. Nature 540: 189191.[Crossref]
  16. AbouZahr C, de Savigny D, Mikkelsen L, Setel PW, Lozano R, Lopez AD, , 2015. Towards universal civil registration and vital statistics systems: the time is now. Lancet 386: 14071418.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.16-0302
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  • Received : 18 Apr 2016
  • Accepted : 05 Mar 2017

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