1921
Volume 95, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Since the first reported case of severe fever with thrombocytopenia syndrome (SFTS) in South Korea in 2013, between 2013 and 2015, we collected 1,697 serum samples from suspected patients who experienced symptoms of SFTS. We performed reverse transcriptase polymerase chain reaction using total RNA extracted from the patients' sera. When viral RNA was detected in the sera, SFTS was diagnosed. Among the 1,697 samples, 170 were positive for SFTS virus. We then analyzed the epidemiologic features of these 170 cases. As a result, we found that the annual number of cases increased steadily. However, the annual case fatality rate exhibited a downward trend. The majority of patients were aged ≥ 60 years, and most cases occurred during May–October in the eastern and southern parts of the country. These results may be useful for effective SFTS control by describing the clinical and epidemiologic features of the disease in South Korea.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.16-0251
2016-12-07
2017-11-19
Loading full text...

Full text loading...

/deliver/fulltext/14761645/95/6/1358.html?itemId=/content/journals/10.4269/ajtmh.16-0251&mimeType=html&fmt=ahah

References

  1. Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang L, Zhang QF, Popov VL, Li C, Qu J, Li Q, Zhang YP, Hai R, Wu W, Wang Q, Zhan FX, Wang XJ, Kan B, Wang SW, Wan KL, Jing HQ, Lu JX, Yin WW, Zhou H, Guan XH, Liu JF, Bi ZQ, Liu GH, Ren J, Wang H, Zhao Z, Song JD, He JR, Wan T, Zhang JS, Fu XP, Sun LN, Dong XP, Feng ZJ, Yang WZ, Hong T, Zhang Y, Walker DH, Wang Y, Li DX, , 2011. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364: 15231532.[Crossref]
  2. Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, Kamei T, Honda M, Ninomiya D, Sakai T, Senba T, Kaneyuki S, Sakaguchi S, Satoh A, Hosokawa T, Kawabe Y, Kurihara S, Izumikawa K, Kohno S, Azuma T, Suemori K, Yasukawa M, Mizutani T, Omatsu T, Katayama Y, Miyahara M, Ijuin M, Doi K, Okuda M, Umeki K, Saito T, Fukushima K, Nakajima K, Yoshikawa T, Tani H, Fukushi S, Fukuma A, Ogata M, Shimojima M, Nakajima N, Nagata N, Katano H, Fukumoto H, Sato Y, Hasegawa H, Yamagishi T, Oishi K, Kurane I, Morikawa S, Saijo M, , 2014. The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 209: 816827.[Crossref]
  3. Kim KH, Yi J, Kim G, Choi SJ, Jun KI, Kim NH, Choe PG, Kim NJ, Lee JK, Oh MD, , 2013. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis 19: 18921894.[Crossref]
  4. Park SW, Han MG, Yun SM, Park C, Lee WJ, Ryou J, , 2014. Severe fever with thrombocytopenia syndrome virus, South Korea, 2013. Emerg Infect Dis 20: 18801882.[Crossref]
  5. McMullan LK, Folk SM, Kelly AJ, MacNeil A, Goldsmith CS, Metcalfe MG, Batten BC, Albarino CG, Zaki SR, Rollin PE, Nicholson WL, Nichol ST, , 2012. A new phlebovirus associated with severe febrile illness in Missouri. N Engl J Med 367: 834841.[Crossref]
  6. Wang J, Selleck P, Yu M, Ha W, Rootes C, Gales R, Wise T, Crameri S, Chen H, Broz I, Hyatt A, Woods R, Meehan B, McCullough S, Wang LF, , 2014. Novel phlebovirus with zoonotic potential isolated from ticks, Australia. Emerg Infect Dis 20: 10401043.[Crossref]
  7. Gai Z, Liang M, Zhang Y, Zhang S, Jin C, Wang SW, Sun L, Zhou N, Zhang Q, Sun Y, Ding SJ, Li C, Gu W, Zhang F, Wang Y, Bian P, Li X, Wang Z, Song X, Wang X, Xu A, Bi Z, Chen S, Li D, , 2012. Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact. Clin Infect Dis 54: 249252.[Crossref]
  8. Liu Y, Li Q, Hu W, Wu J, Wang Y, Mei L, Walker DH, Ren J, Yu XJ, , 2012. Person-to-person transmission of severe fever with thrombocytopenia syndrome virus. Vector Borne Zoonotic Dis 12: 156160.[Crossref]
  9. Kim WY, Choi W, Park SW, Wang EB, Lee WJ, Jee Y, Lim KS, Lee HJ, Kim SM, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH, , 2015. Nosocomial transmission of severe fever with thrombocytopenia syndrome in Korea. Clin Infect Dis 60: 16811683.[Crossref]
  10. Yun SM, Lee WG, Ryou J, Yang SC, Park SW, Roh JY, Lee YJ, Park C, Han MG, , 2014. Severe fever with thrombocytopenia syndrome virus in ticks collected from humans, South Korea, 2013. Emerg Infect Dis 20: 13581361.[Crossref]
  11. Xing X, Guan X, Liu L, Zhan J, Jiang H, Li G, Xiong J, Tan L, Xu J, Jiang Y, Yao X, Zhan F, Nie S, , 2016. Natural transmission model for severe fever with thrombocytopenia syndrome bunyavirus in villages of Hubei Province, China. Medicine (Baltimore) 95: e2533.[Crossref]
  12. Park SW, Song BG, Shin EH, Yun SM, Han MG, Park MY, Park C, Ryou J, , 2014. Prevalence of severe fever with thrombocytopenia syndrome virus in Haemaphysalis longicornis ticks in South Korea. Ticks Tick Borne Dis 5: 975977.[Crossref]
  13. Oh WS, Heo ST, Kim SH, Choi WJ, Han MG, Kim JY, , 2014. Plasma exchange and ribavirin for rapidly progressive severe fever with thrombocytopenia syndrome. Int J Infect Dis 18: 8486.[Crossref]
  14. Gai ZT, Zhang Y, Liang MF, Jin C, Zhang S, Zhu CB, Li C, Li XY, Zhang QF, Bian PF, Zhang LH, Wang B, Zhou N, Liu JX, Song XG, Xu A, Bi ZQ, Chen SJ, Li DX, , 2012. Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients. J Infect Dis 206: 10951102.[Crossref]
  15. Lee HW, Lee HW, Calisher C, Schmaljohn C, , 1999. Virus isolation. , ed. Manual of Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome. Seoul, South Korea: WHO Collaborating Centre for Virus Reference and Research (Hantavirus), 7479.
  16. Liu S, Chai C, Wang C, Amer S, Lv H, He H, Sun J, Lin J, , 2014. Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics. Rev Med Virol 24: 90102.[Crossref]
  17. Liu K, Zhou H, Sun RX, Yao HW, Li Y, Wang LP, Mu D, Li XL, Yang Y, Gray GC, Cui N, Yin WW, Fang LQ, Yu HJ, Cao WC, , 2015. A national assessment of the epidemiology of severe fever with thrombocytopenia syndrome, China. Sci Rep 5: 9679.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.16-0251
Loading
/content/journals/10.4269/ajtmh.16-0251
Loading

Data & Media loading...

  • Received : 01 Apr 2016
  • Accepted : 13 Jun 2016

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error