1921
Volume 95, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Chloroquine (CQ) remains the first-line treatment of malaria in Haiti. Given the challenges of conducting in vivo drug efficacy trials in low-endemic settings like Haiti, molecular surveillance for drug resistance markers is a reasonable approach for detecting resistant parasites. In this study, 349 blood spots were collected from suspected malaria cases in areas in and around Port-au-Prince from March to July 2010. Among them, 121 samples that were positive by polymerase chain reaction were genotyped for drug-resistant , , , and alleles. Among the 108 samples that were successfully sequenced for CQ resistant markers in , 107 were wild type (CVMNK), whereas one sample carried a CQ-resistant allele (CVIET). Neutral microsatellite genotyping revealed that the CQ-resistant isolate was distinct from all other samples in this study. Furthermore, the remaining parasite specimens appeared to be genetically distinct from other reported Central and South American populations.

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/content/journals/10.4269/ajtmh.16-0214
2016-10-05
2017-09-20
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Supplementary Data

Supplementary PDF

  • Received : 16 Mar 2016
  • Accepted : 01 Jun 2016

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