Volume 95, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Chagas disease, caused by the parasite , affects more than 5 million people worldwide leading to serious heart and gastrointestinal disease in a proportion of chronically infected patients. Important modes of transmission include vector-borne, congenital, and via blood transfusion or organ transplant from an infected donor. Vector-borne transmission of Chagas disease occurs in the Americas, including the southern half of North America, where the specific vector insects (triatomines), , and infected reservoir mammalian hosts are found. In the United States, there are estimated to be at least 300,000 cases of chronic Chagas disease among people originally from countries of Latin America where Chagas disease is endemic. Fewer than 30 cases of locally acquired infection have been documented in the United States, although a sylvatic transmission cycle has been known to exist in this country for at least a century. Studies defining risks for locally acquired infection and effective prevention strategies are needed to help prevent domestic transmission of . To help address Chagas disease in the United States, improved health-care provider awareness and knowledge, better tools for screening and diagnosing patients, and wider availability of treatment drugs are needed.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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  1. Rassi A, Jr Rassi A, Marin-Neto JA, , 2010. Chagas disease. Lancet 375: 13881402.[Crossref]
  2. World Health Organization, 2015. Chagas disease in Latin America: an epidemiological update based on 2010 estimates. Wkly Epidemiol Rec 6: 3343.
  3. Bern C, Montgomery SP, , 2009. An estimate of the burden of Chagas disease in the United States. Clin Infect Dis 49: 655681.[Crossref]
  4. Stimpert KK, Montgomery SP, , 2010. Physician awareness of Chagas disease, USA. Emerg Infect Dis. 16: 871872.[Crossref]
  5. Verani JR, Montgomery SP, Schulkin J, Anderson B, Jones JL, , 2010. Survey of obstetrician-gynecologists in the United States about Chagas disease. Am J Trop Med Hyg 83: 891895.[Crossref]
  6. Kofoid CA, Donat F, , 1916. On Trypanosoma triatomae, a new flagellate from a hemipteran bug from the nests of the wood rat Neotoma fuscipes . Univ Calif Publ Zool 16: 113126.
  7. Bern C, Kjos S, Yabsley MJ, Montgomery SP, , 2011. Trypanosoma cruzi and Chagas' disease in the United States. Clin Microbiol Rev 24: 655681.[Crossref]
  8. Almeida CE, Francischetti CN, Pacheco RS, Costa J, , 2003. Triatoma rubrovaria (Blanchard, 1843) (Hemiptera-Reduviidae-Triatominae) III. Patterns of feeding, defecation and resistance to starvation. Mem Inst Oswaldo Cruz 98: 367371.[Crossref]
  9. Dias E, , 1956. Observacoes sobre elimancao de dejecoes e tempo de succao em alguns triatomineos sulamericanos. Mem Inst Oswaldo Cruz 54: 115124.[Crossref]
  10. Zeledon R, Alvarado R, Jiron LF, , 1977. Observations of the feeding and defecation patterns of three triatomine species (Hemiptera: Reduviidae). Acta Trop 34: 6577.
  11. Klotz SA, Dorn PL, Klotz JH, Pinnas JL, Weinrach C, Kurtz JR, Schmidt J, , 2009. Feeding behavior of triatomines from the southwestern United States: an update on potential risk for transmission of Chagas disease. Acta Trop 111: 114118.[Crossref]
  12. Riesenman CE, Gregory T, Guerenstein PG, Hildebrand JG, , 2011. Feeding and defecation behavior of Triatoma rubida (Uhler, 1894) (Hemiptera: Reduviidae) under laboratory conditions, and its potential role as a vector of Chagas disease in Arizona, USA. Am J Trop Med Hyg 85: 648656.[Crossref]
  13. Wood SF, , 1951. Importance of feeding and defecation times of insect vectors in transmission of Chagas' disease. J Econ Entomol 44: 5254.[Crossref]
  14. Pippin WF, , 1970. The biology and vector capability of Triatoma sanguisuga texana Usinger and Triatoma gerstaeckeri (Stal) compared with Rhodnius prolixus (Stal) (Hemiptera: Triatominae). J Med Entomol 7: 3045.[Crossref]
  15. Cantey PT, Stramer SL, Townsend RL, Kamel H, Ofafa K, Todd CW, Currier M, Hand S, Varnado W, Dotson E, Hall C, Jett PL, Montgomery SP, , 2012. The United States Trypanosoma cruzi Infection Study: evidence for vector-borne transmission of the parasite that causes Chagas disease among United States blood donors. Transfusion 52: 19221930.[Crossref]
  16. Garcia MN, Aguilar D, Gorchakov R, Rossmann SN, Montgomery SP, Rivera H, Woc-Colburn L, Hotez PJ, Murray KO, , 2015. Case report: evidence of autochthonous Chagas disease in southeastern Texas. Am J Trop Med Hyg 92: 325330.[Crossref]
  17. Garcia MN, Hotez PJ, Murray KO, , 2014. Potential novel risk factors for autochthonous and sylvatic transmission of human Chagas disease in the United States. Parasit Vectors 7: 311.[Crossref]
  • Received : 16 Mar 2016
  • Accepted : 24 May 2016

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