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Control and Elimination of Plasmodium vivax Malaria: The Evidence Base
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Brazil is the largest country of Latin America, with a considerable portion of its territoritory within the malaria-endemic Amazon region in the North. Furthermore, a considerable portion of its territory is located within the Amazon region in the north. As a result, Brazil has reported half of the total malaria cases in the Americas in the last four decades. Recent progress in malaria control has been accompanied by an increasing proportion of , underscoring a need for a better understanding of management and control of this species and associated challenges. Among these challenges, the contribution of vivax malaria relapses, earlier production of gametocytes (compared with ), inexistent methods to diagnose hypnozoite carriers, and decreasing efficacy of available antimalarials need to be addressed. Innovative tools, strategies, and technologies are needed to achieve further progress toward sustainable malaria elimination. Further difficulties also arise from dealing with the inherent socioeconomic and environmental particularities of the Amazon region and its dynamic changes.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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2016-12-28
2017-09-21
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References

  1. Barreto ML, Teixeira MG, Bastos FI, Ximenes RA, Barata RB, Rodrigues LC, , 2011. Successes and failures in the control of infectious diseases in Brazil: social and environmental context, policies, interventions, and research needs. Lancet 377: 18771889.[Crossref]
  2. World Health Organization, 2015. World Malaria Report 2015. Geneva, Switzerland: World Health Organization.
  3. Oliveira-Ferreira J, Lacerda MV, Brasil P, Ladislau JL, Tauil PL, Daniel-Ribeiro CT, , 2010. Malaria in Brazil: an overview. Malar J 9: 115.[Crossref]
  4. Griffing SM, Tauil PL, Udhayakumar V, Silva-Flannery L, , 2015. A historical perspective on malaria control in Brazil. Mem Inst Oswaldo Cruz 110: 701718.[Crossref]
  5. Sampaio VS, Siqueira AM, Alecrim M, Mourao MP, Marchesini PB, Albuquerque BC, Nascimento J, Figueira EA, Alecrim WD, Monteiro WM, Lacerda MV, , 2015. Malaria in the State of Amazonas: a typical Brazilian tropical disease influenced by waves of economic development. Rev Soc Bras Med Trop 48 (Suppl 1): 411.[Crossref]
  6. Val FF, Sampaio VS, Cassera MB, Andrade RT, Tauil PL, Monteiro WM, Lacerda MV, , 2014. Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited? Mem Inst Oswaldo Cruz 109: 522524.[Crossref]
  7. Cohen JM, Smith DL, Cotter C, Ward A, Yamey G, Sabot OJ, Moonen B, , 2012. Malaria resurgence: a systematic review and assessment of its causes. Malar J 11: 122.[Crossref]
  8. Alecrim MG, Lacerda MV, Mourao MP, Alecrim WD, Padilha A, Cardoso BS, Boulos M, , 2006. Successful treatment of Plasmodium falciparum malaria with a six-dose regimen of artemether-lumefantrine versus quinine-doxycycline in the western Amazon region of Brazil. Am J Trop Med Hyg 74: 2025.
  9. Santelli AC, Ribeiro I, Daher A, Boulos M, Marchesini PB, dos Santos RL, Lucena MB, Magalhaes I, Leon AP, Junger W, Ladislau JL, , 2012. Effect of artesunate-mefloquine fixed-dose combination in malaria transmission in Amazon basin communities. Malar J 11: 286.[Crossref]
  10. Bousema T, Drakeley C, , 2011. Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination. Clin Microbiol Rev 24: 377410.[Crossref]
  11. Coimbra CE, Jr Santos RV, Welch JR, Cardoso AM, de Souza MC, Garnelo L, Rassi E, Foller ML, Horta BL, , 2013. The First National Survey of Indigenous People's Health and Nutrition in Brazil: rationale, methodology, and overview of results. BMC Public Health 13: 52.[Crossref]
  12. Oliveira FPd, Vanni T, Pinto HA, Santos JTRd, Figueiredo AMd, Araújo SQd, Matos MFM, Cyrino EG, , 2015. Mais Médicos: um programa brasileiro em uma perspectiva internacional. Interface (Botucatu) 19: 623634 (online).[Crossref]
  13. Mourao MP, Bastos M de S, Figueiredo RM, Gimaque JB, Alves V do C, Saraiva M, Figueiredo ML, Ramasawmy R, Nogueira ML, Figueiredo LT, , 2015. Arboviral diseases in the western Brazilian Amazon: a perspective and analysis from a tertiary health and research center in Manaus, State of Amazonas. Rev Soc Bras Med Trop 48 (Suppl 1): 2026.[Crossref]
  14. Tadei WP, Thatcher BD, Santos JM, Scarpassa VM, Rodrigues IB, Rafael MS, , 1998. Ecologic observations on anopheline vectors of malaria in the Brazilian Amazon. Am J Trop Med Hyg 59: 325335.
  15. Vasconcelos CH, Novo EM, Donalisio MR, , 2006. Uso do sensoriamento remoto para estudar a influencia de alteracoes ambientais na distribuicao da malaria na Amazonia brasileira. Cad Saude Publica 22: 517526.[Crossref]
  16. Klein TA, Lima JB, Tada MS, Miller R, , 1991. Comparative susceptibility of anopheline mosquitoes in Rondonia, Brazil to infection by Plasmodium vivax . Am J Trop Med Hyg 45: 463470.
  17. Martins-Campos KM, Pinheiro WD, Vitor-Silva S, Siqueira AM, Melo GC, Rodrigues IC, Fe NF, Barbosa M, Tadei WP, Guinovart C, Bassat Q, Alonso PL, Lacerda MV, Monteiro WM, , 2012. Integrated vector management targeting Anopheles darlingi populations decreases malaria incidence in an unstable transmission area, in the rural Brazilian Amazon. Malar J 11: 351.[Crossref]
  18. Scarpassa VM, Cunha-Machado AS, Saraiva JF, , 2016. Evidence of new species for malaria vector Anopheles nuneztovari sensu lato in the Brazilian Amazon region. Malar J 15: 205.[Crossref]
  19. Morais SA, Urbinatti PR, Sallum MA, Kuniy AA, Moresco GG, Fernandes A, Nagaki SS, Natal D, , 2012. Brazilian mosquito (Diptera: Culicidae) fauna: I. Anopheles species from Porto Velho, Rondonia state, western Amazon, Brazil. Rev Inst Med Trop Sao Paulo 54: 331335.[Crossref]
  20. Gil LH, Rodrigues M de S, de Lima AA, Katsuragawa TH, , 2015. Seasonal distribution of malaria vectors (Diptera: Culicidae) in rural localities of Porto Velho, Rondonia, Brazilian Amazon. Rev Inst Med Trop Sao Paulo 57: 263267.[Crossref]
  21. Katsuragawa TH, Cunha RP, de Souza DC, Gil LH, Cruz RB, Silva A de A, Tada MS, da Silva LH, , 2009. Malaria e aspectos hematologicos em moradores da area de influencia dos futuros reservatorios das hidreletricas de Santo Antonio e Jirau, Rondonia, Brasil. Cadernos de saude publica/Ministerio da Saude, Fundacao Oswaldo Cruz. Escola Nacional de Saude Publica 25: 14861492.
  22. Costa KM, de Almeida WA, Magalhaes IB, Montoya R, Moura MS, de Lacerda MV, , 2010. Malaria em Cruzeiro do Sul (Amazonia Ocidental brasileira): analise da serie historica de 1998 a 2008. Rev Panam Salud Publica 28: 353360.[Crossref]
  23. Reis IC, Honorio NA, Barros FS, Barcellos C, Kitron U, Camara DC, Pereira GR, Keppeler EC, da Silva-Nunes M, Codeco CT, , 2015. Epidemic and endemic malaria transmission related to fish farming ponds in the Amazon frontier. PLoS One 10: e0137521.[Crossref]
  24. Ladeia-Andrade S, Ferreira MU, de Carvalho ME, Curado I, Coura JR, , 2009. Age-dependent acquisition of protective immunity to malaria in riverine populations of the Amazon Basin of Brazil. Am J Trop Med Hyg 80: 452459.
  25. Siqueira AM, Cavalcante JA, Vítor-Silva S, Reyes-Lecca RC, Alencar AC, Monteiro WM, Alexandre MAA, Maria Paula GM, Guinovart C, Bassat Q, Alecrim M d GC, Lacerda MVG, , 2014. Influence of age on the haemoglobin concentration of malaria-infected patients in a reference centre in the Brazilian Amazon. Mem Inst Oswaldo Cruz 109: 569576.[Crossref]
  26. Shanks GD, , 2012. Control and elimination of Plasmodium vivax . Adv Parasitol 80: 301341.[Crossref]
  27. Battle KE, Karhunen MS, Bhatt S, Gething PW, Howes RE, Golding N, Van Boeckel TP, Messina JP, Shanks GD, Smith DL, Baird JK, Hay SI, , 2014. Geographical variation in Plasmodium vivax relapse. Malar J 13: 144.[Crossref]
  28. Katsuragawa TH, Gil LH, Tada MS, de Almeida e Silva A, Costa JD, Araujo M da S, Escobar AL, da Silva LH, , 2010. The dynamics of transmission and spatial distribution of malaria in riverside areas of Porto Velho, Rondonia, in the Amazon region of Brazil. PLoS One 5: e9245.[Crossref]
  29. Vitor-Silva S, Siqueira AM, de Souza Sampaio V, Guinovart C, Reyes-Lecca RC, de Melo GC, Monteiro WM, Del Portillo HA, Alonso P, Bassat Q, Lacerda MV, , 2016. Declining malaria transmission in rural Amazon: changing epidemiology and challenges to achieve elimination. Malar J 15: 266.[Crossref]
  30. Simões LR, Alves ER, Jr Ribatski-Silva D, Gomes LT, Nery AF, Fontes CJF, , 2014. Factors associated with recurrent Plasmodium vivax malaria in Porto Velho, Rondonia State, Brazil, 2009. Cad Saude Publica 30: 14031417.[Crossref]
  31. Boulos M, Amato Neto V, Dutra AP, Di Santi SM, Shiroma M, , 1991. Analise da frequencia de recaidas de malaria por Plasmodium vivax em regiao nao endemica (Sao Paulo, Brasil). Rev Inst Med Trop Sao Paulo 33: 143146.[Crossref]
  32. Pedro RS, Guaraldo L, Campos DP, Costa AP, Daniel-Ribeiro CT, Brasil P, , 2012. Plasmodium vivax malaria relapses at a travel medicine centre in Rio de Janeiro, a non-endemic area in Brazil. Malar J 11: 245.[Crossref]
  33. Brasil P, de Pina Costa A, Pedro RS, da Silveira Bressan C, da Silva S, Tauil PL, Daniel-Ribeiro CT, , 2011. Unexpectedly long incubation period of Plasmodium vivax malaria, in the absence of chemoprophylaxis, in patients diagnosed outside the transmission area in Brazil. Malar J 10: 122.[Crossref]
  34. de Araujo FC, de Rezende AM, Fontes CJ, Carvalho LH, Alves de Brito CF, , 2012. Multiple-clone activation of hypnozoites is the leading cause of relapse in Plasmodium vivax infection. PLoS One 7: e49871.[Crossref]
  35. Imwong M, Snounou G, Pukrittayakamee S, Tanomsing N, Kim JR, Nandy A, Guthmann JP, Nosten F, Carlton J, Looareesuwan S, Nair S, Sudimack D, Day NP, Anderson TJ, White NJ, , 2007. Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. J Infect Dis 195: 927933.[Crossref]
  36. Imwong M, Boel ME, Pagornrat W, Pimanpanarak M, McGready R, Day NP, Nosten F, White NJ, , 2012. The first Plasmodium vivax relapses of life are usually genetically homologous. J Infect Dis 205: 680683.[Crossref]
  37. Santos-Ciminera PD, Roberts DR, Alecrim M, Costa MR, Quinnan GV, Jr, 2007. Malaria diagnosis and hospitalization trends, Brazil. Emerg Infect Dis 13: 15971600.[Crossref]
  38. Lacerda MV, Mourao MP, Alexandre MA, Siqueira AM, Magalhaes BM, Martinez-Espinosa FE, Filho FS, Brasil P, Ventura AM, Tada MS, Couto VS, Silva AR, Silva RS, Alecrim MG, , 2012. Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature. Malar J 11: 12.[Crossref]
  39. Siqueira AM, Lacerda MV, Magalhaes BM, Mourao MP, Melo GC, Alexandre MA, Alecrim MG, Kochar D, Kochar S, Kochar A, Nayak K, Del Portillo H, Guinovart C, Alonso P, Bassat Q, , 2015. Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India. BMC Med 13: 57.[Crossref]
  40. Magalhaes BM, Siqueira AM, Alexandre MA, Souza MS, Gimaque JB, Bastos MS, Figueiredo RM, Melo GC, Lacerda MV, Mourao MP, , 2014. P. vivax malaria and dengue fever co-infection: a cross-sectional study in the Brazilian Amazon. PLoS Negl Trop Dis 8: e3239.[Crossref]
  41. Pina-Costa AD, Brasil P, Di Santi SM, de Araujo MP, Suárez-Mutis MC, Santelli AC, Oliveira-Ferreira J, Lourenço-de-Oliveira R, Daniel-Ribeiro CT, , 2014. Malaria in Brazil: what happens outside the Amazonian endemic region. Mem Inst Oswaldo Cruz 109: 618633.[Crossref]
  42. Lacerda MV, Fragoso SC, Alecrim MG, Alexandre MA, Magalhaes BM, Siqueira AM, Ferreira LC, Araujo JR, Mourao MP, Ferrer M, Castillo P, Martin-Jaular L, Fernandez-Becerra C, del Portillo H, Ordi J, Alonso PL, Bassat Q, , 2012. Postmortem characterization of patients with clinical diagnosis of Plasmodium vivax malaria: to what extent does this parasite kill? Clin Infect Dis 55: e67e74.[Crossref]
  43. Braz RM, Duarte EC, Tauil PL, , 2013. Caracterizacao das epidemias de malaria nos municipios da Amazonia Brasileira em 2010. Cad Saude Publica 29: 935944.[Crossref]
  44. Foley DH, Linton YM, Ruiz-Lopez JF, Conn JE, Sallum MA, Povoa MM, Bergo ES, Oliveira TM, Sucupira I, Wilkerson RC, , 2014. Geographic distribution, evolution, and disease importance of species within the Neotropical Anopheles albitarsis Group (Diptera, Culicidae). J Vector Ecol 39: 168181.[Crossref]
  45. Siqueira AM, , 2014. Sleepless in the Liver. Available at: http://www.malariaworld.org/blog/column-sleepless-liver-would-revisiting-past-give-any-directions-how-deal-hypnozoite-carriers-p. Accessed December 29, 2014.
  46. Santana MS, Monteiro WM, Siqueira AM, Costa MF, Sampaio V, Lacerda MV, Alecrim MG, , 2013. Glucose-6-phosphate dehydrogenase deficient variants are associated with reduced susceptibility to malaria in the Brazilian Amazon. Trans R Soc Trop Med Hyg 107: 301306.[Crossref]
  47. Monteiro WM, Franca GP, Melo GC, Queiroz AL, Brito M, Peixoto HM, Oliveira MR, Romero GA, Bassat Q, Lacerda MV, , 2014. Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes. Malar J 13: 70.[Crossref]
  48. Ramos Junior WM, Sardinha JF, Costa MR, Santana MS, Alecrim MG, Lacerda MV, , 2010. Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon. Braz J Infect Dis 14: 410412.[Crossref]
  49. Ministério da Saúde (Brasil), 2013. Situação epidemiológica da malária no Brasil, 2000 a 2011. Boletim Epidemiológico 44: 116.
  50. Ministério da Saúde, 2010. Guia prático de tratamento da malária no Brasil. Brasília, Brazil: Ministerio da Saúde.
  51. Pereira EA, Ishikawa EA, Fontes CJ, , 2011. Adherence to Plasmodium vivax malaria treatment in the Brazilian Amazon Region. Malar J 10: 355.[Crossref]
  52. Siqueira AM, Coutinho LI, Gurgel RL, Su WC, Carvalho LM, Benzecry SG, Alencar AC, Alexandre MA, Alecrim MG, Lacerda MV, , 2014. Slow clearance of Plasmodium vivax with chloroquine amongst children younger than six months of age in the Brazilian Amazon. Mem Inst Oswaldo Cruz 109: 540545.[Crossref]
  53. Ladeia-Andrade S, de Melo GN, de Souza-Lima R de C, Salla LC, Bastos MS, Rodrigues PT, Luz F, Ferreira MU, , 2016. No clinical or molecular evidence of Plasmodium falciparum resistance to artesunate-mefloquine in northwestern Brazil. Am J Trop Med Hyg 95: 148154.[Crossref]
  54. Ballut PC, Siqueira AM, Orlando AC, Alexandre MA, Alecrim MG, Lacerda MV, , 2013. Prevalence and risk factors associated to pruritus in Plasmodium vivax patients using chloroquine in the Brazilian Amazon. Acta Trop 128: 504508.[Crossref]
  55. Santana MS, da Rocha MA, Arcanjo AR, Sardinha JF, Alecrim WD, Alecrim MG, , 2007. Associacao de metemoglobinemia e deficiencia de glicose-6-fosfato desidrogenase em pacientes com malaria tratados com primaquina. Rev Soc Bras Med Trop 40: 533536.[Crossref]
  56. Alecrim MG, Alecrim W, Macedo V, , 1999. Plasmodium vivax resistance to chloroquine (R2) and mefloquine (R3) in Brazilian Amazon region. Rev Soc Bras Med Trop 32: 6768.[Crossref]
  57. de Santana Filho FS, Arcanjo AR, Chehuan YM, Costa MR, Martinez-Espinosa FE, Vieira JL, Barbosa M, Alecrim WD, Alecrim M, , 2007. Chloroquine-resistant Plasmodium vivax, Brazilian Amazon. Emerg Infect Dis 13: 11251126.[Crossref]
  58. Llanos-Cuentas A, Lacerda MV, Rueangweerayut R, Krudsood S, Gupta SK, Kochar SK, Arthur P, Chuenchom N, Mohrle JJ, Duparc S, Ugwuegbulam C, Kleim JP, Carter N, Green JA, Kellam L, , 2014. Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study. Lancet 383: 10491058.[Crossref]
  59. Cunha MG, Silva ES, Sepulveda N, Costa SP, Saboia TC, Guerreiro JF, Povoa MM, Corran PH, Riley E, Drakeley CJ, , 2014. Serologically defined variations in malaria endemicity in Para state, Brazil. PLoS One 9: e113357.[Crossref]
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  • Received : 14 Mar 2016
  • Accepted : 19 Aug 2016

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