1921
Volume 95, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Santa Catarina State in southern Brazil is the state with the second highest number of laboratory-confirmed cases of spotted fever illness in Brazil. However, all these cases were confirmed solely by serological analysis (seroconversion to spotted fever group rickettsiae), which has not allowed identification of the rickettsial agent. Here, a clinical case of spotted fever illness from Santa Catarina is shown by seroconversion and molecular analysis to be caused by sp. strain Atlantic rainforest. This is the third confirmed clinical case due to this emerging rickettsial agent in Brazil. Like the previous two cases, the patient presented an inoculation eschar at the tick bite site. Our molecular diagnosis was performed on DNA extracted from the crust removed from the eschar. These results are supported by previous epidemiological studies in Santa Catarina, which showed that nearly 10% of the most common human-biting ticks were infected by sp. strain Atlantic rainforest.

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2016-09-07
2017-09-26
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References

  1. Spolidorio MG, Labruna MB, Mantovani E, Brandão P, Richtzenhain LJ, Yoshinari NH, , 2010. Novel spotted fever group rickettsioses, Brazil. Emerg Infect Dis 16: 521523.[Crossref]
  2. Silva N, Eremeeva ME, Rozental T, Ribeiro GS, Paddock CD, Ramos EAG, Favacho ARM, Reis MG, Dasch GA, de Lemos ERS, Ko AI, , 2011. Eschar-associated spotted fever rickettsiosis, Bahia, Brazil. Emerg Infect Dis 17: 275278.[Crossref]
  3. Parola P, Paddock CD, Socolovschi C, Labruna MB, Mediannikov O, Kernif T, Abdad MY, Stenos J, Bitam I, Fournier PE, Raoult D, , 2013. Update on tick-borne rickettsioses around the world: a geographic approach. Clin Microbiol Rev 26: 657702.[Crossref]
  4. Nieri-Bastos FA, Horta MC, Barros-Battesti DM, Moraes-Filho J, Ramirez DG, Martins TF, Labruna MB, , 2016. Isolation of the pathogen Rickettsia sp. strain Atlantic rainforest from its presumed tick vector, Amblyomma ovale (Acari: Ixodidae), from two areas of Brazil. J Med Entomol pii: tjw062.
  5. Paddock CD, Finley RW, Wright CS, Robinson HN, Schrodt BJ, Lane CC, Ekenna O, Blass MA, Tamminga CL, Ohl CA, McLellan SL, Goddard J, Holman RC, Openshaw JJ, Sumner JW, Zaki SR, Eremeeva ME, , 2008. Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever. Clin Infect Dis 47: 11881196.[Crossref]
  6. Conti-Díaz IA, Moraes-Filho J, Pacheco RC, Labruna MB, , 2009. Serological evidence of Rickettsia parkeri as the etiological agent of rickettsiosis in Uruguay. Rev Inst Med Trop Sao Paulo 51: 337339.[Crossref]
  7. Romer Y, Nava S, Govedic F, Cicuttin G, Denison AM, Singleton J, Kelly AJ, Kato CY, Paddock CD, , 2014. Rickettsia parkeri rickettsiosis in different ecological regions of Argentina and its association with Amblyomma tigrinum as a potential vector. Am J Trop Med Hyg 91: 11561160.[Crossref]
  8. Angerami RN, da Silva AM, Nascimento EM, Colombo S, Wada MY, dos Santos FC, Mancini DM, de Oliveira RC, Katz G, Martins EC, da Silva LJ, , 2009. Brazilian spotted fever: two faces of a same disease? A comparative study of clinical aspects between an old and a new endemic area in Brazil. Clin Microbiol Infect 2 (Suppl): 207208.[Crossref]
  9. Barros e Silva PMR, Pereira SC, Fonseca LX, Maniglia FVP, Oliveira SV, de Caldas EP, , 2014. Febre maculosa: uma análise epidemiológica dos registros dosistema de vigilância do Brasil. Scientia Plena 10: 19.
  10. Barbieri ARM, Moraes-Filho J, Nieri-Bastos FA, Souza JC, Szabó MPJ, Labruna MB, , 2014. Epidemiology of Rickettsia sp. strain Atlantic rainforest in a spotted fever-endemic area of southern Brazil. Ticks Tick Borne Dis 5: 848853.[Crossref]
  11. Labruna MB, Horta MC, Aguiar DM, Cavalcante GT, Pinter A, Gennari SM, Camargo LMA, , 2007. Prevalence of Rickettsia infection in dogs from the urban and rural areas of Monte Negro Municipality, western Amazon, Brazil. Vector Borne Zoonotic Dis 7: 249255.[Crossref]
  12. Eremeeva ME, Bosserman EA, Demma LJ, Zambrano ML, Blau DM, Dasch GA, , 2006. Isolation and identification of Rickettsia massiliae from Rhipicephalus sanguineus ticks collected in Arizona. Appl Environ Microbiol 72: 55695577.[Crossref]
  13. Roux V, Raoult D, , 2000. Phylogenetic analysis of members of the genus Rickettsia using the gene encoding the outer membrane protein rOmpB (ompB). Int J Syst Evol Microbiol 50: 14491455.[Crossref]
  14. Medeiros AP, de Souza AP, de Moura AB, Lavina MS, Belatto V, Sartor AA, Nieri-Bastos FA, Richtzenhain LJ, Labruna MB, , 2011. Spotted fever group Rickettsia infecting ticks (Acari: Ixodidae) in the state of Santa Catarina, Brazil. Mem Inst Oswaldo Cruz 106: 926930.[Crossref]
  15. Krawczak FS, Agostinho WC, Polo G, Moraes-Filho J, Labruna MB, , 2016. Comparative evaluation of Amblyomma ovale ticks infected and noninfected by Rickettsia sp. strain Atlantic rainforest, the agent of an emerging rickettsiosis in Brazil. Ticks Tick Borne Dis 7: 502507.[Crossref]
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  • Received : 09 Mar 2016
  • Accepted : 17 May 2016

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