1921
Volume 95, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Serological evidence of the epidemiological trends in infection is scarce, especially in nonendemic countries. We aimed to determine the antibody-positive rates over a 10-year period, and compare the trends between human immunodeficiency virus (HIV)–infected and –noninfected patients. We reviewed 3,514 patients who underwent antibody testing during the study periods, which were divided into five annual categories: 2004–2005, 2006–2007, 2008–2009, 2010–2011, and 2012–2013. Anti- antibody was assessed by indirect immunofluorescence assay. The antibody-positive rate increased yearly from 2004–2005 to 2012–2013 ( < 0.001), although there was no increase in the annual number of antibody tests. This trend was seen among males (18.6–28.3%; < 0.01), females (5.4–28.2%; < 0.01), HIV-infected patients (18.4–26.9%; < 0.001), and non-HIV-infected patients (14.6–36.8%; < 0.001), and HIV-infected men who have sex with men (19.4–29.1%; < 0.001). Among antibody-positive patients, there was a significant increase in the proportion of patients with high (≥ 1,600) titers (0.7–12.9%; < 0.001), whereas this trend was not seen in patients with low (100) or intermediate (200–800) titers ( = 0.282 and 0.409, respectively). This large hospital-based study demonstrated that positive anti- antibody rates increased over 10 years, even though the annual number of antibody tests remained constant. Moreover, this trend was identified in non-high-risk patients (females and non-HIV-infected patients) as well as in high-risk patients. The proportion of patients with high antibody titers significantly increased among the antibody-positive patients.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.16-0134
2016-09-07
2019-11-19
Loading full text...

Full text loading...

/deliver/fulltext/14761645/95/3/604.html?itemId=/content/journals/10.4269/ajtmh.16-0134&mimeType=html&fmt=ahah

References

  1. Stanley SL, Jr, 2003. Amoebiasis. Lancet 361: 10251034.[Crossref] [Google Scholar]
  2. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Barker-Collo S, Bartels DH, Bell ML, Benjamin EJ, Bennett D, Bhalla K, Bikbov B, Bin Abdulhak A, Birbeck G, Blyth F, Bolliger I, Boufous S, Bucello C, Burch M, Burney P, Carapetis J, Chen H, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahodwala N, De Leo D, Degenhardt L, Delossantos A, Denenberg J, Des Jarlais DC, Dharmaratne SD, Dorsey ER, Driscoll T, Duber H, Ebel B, Erwin PJ, Espindola P, Ezzati M, Feigin V, Flaxman AD, Forouzanfar MH, Fowkes FG, Franklin R, Fransen M, Freeman MK, Gabriel SE, Gakidou E, Gaspari F, Gillum RF, Gonzalez-Medina D, Halasa YA, Haring D, Harrison JE, Havmoeller R, Hay RJ, Hoen B, Hotez PJ, Hoy D, Jacobsen KH, James SL, Jasrasaria R, Jayaraman S, Johns N, Karthikeyan G, Kassebaum N, Keren A, Khoo JP, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Lipnick M, Lipshultz SE, Ohno SL, Mabweijano J, MacIntyre MF, Mallinger L, March L, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGrath J, Mensah GA, Merriman TR, Michaud C, Miller M, Miller TR, Mock C, Mocumbi AO, Mokdad AA, Moran A, Mulholland K, Nair MN, Naldi L, Narayan KM, Nasseri K, Norman P, O'Donnell M, Omer SB, Ortblad K, Osborne R, Ozgediz D, Pahari B, Pandian JD, Rivero AP, Padilla RP, Perez-Ruiz F, Perico N, Phillips D, Pierce K, Pope CA, 3rd Porrini E, Pourmalek F, Raju M, Ranganathan D, Rehm JT, Rein DB, Remuzzi G, Rivara FP, Roberts T, De Leon FR, Rosenfeld LC, Rushton L, Sacco RL, Salomon JA, Sampson U, Sanman E, Schwebel DC, Segui-Gomez M, Shepard DS, Singh D, Singleton J, Sliwa K, Smith E, Steer A, Taylor JA, Thomas B, Tleyjeh IM, Towbin JA, Truelsen T, Undurraga EA, Venketasubramanian N, Vijayakumar L, Vos T, Wagner GR, Wang M, Wang W, Watt K, Weinstock MA, Weintraub R, Wilkinson JD, Woolf AD, Wulf S, Yeh PH, Yip P, Zabetian A, Zheng ZJ, Lopez AD, Murray CJ, AlMazroa MA, Memish ZA, , 2012. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010. Lancet 380: 20952128.[Crossref] [Google Scholar]
  3. Caballero-Salcedo A, Viveros-Rogel M, Salvatierra B, Tapia-Conyer R, Sepulveda-Amor J, Gutierrez G, Ortiz-Ortiz L, , 1994. Seroepidemiology of amebiasis in Mexico. Am J Trop Med Hyg 50: 412419. [Google Scholar]
  4. Chacin-Bonilla L, Mathews H, Dikdan Y, Guanipa N, , 1990. Seroepidemiologic study of amebiasis in a community of the State of Zulia, Venezuela. Rev Inst Med Trop Sao Paulo 32: 467473.[Crossref] [Google Scholar]
  5. Cross JH, Tsai SH, , 1982. Indirect hemagglutination antibody titers for Entamoeba histolytica in dried filter paper blood and sera. Southeast Asian J Trop Med Public Health 13: 6972. [Google Scholar]
  6. Pillai DR, Keystone JS, Sheppard DC, MacLean JD, MacPherson DW, Kain KC, , 1999. Entamoeba histolytica and Entamoeba dispar: epidemiology and comparison of diagnostic methods in a setting of nonendemicity. Clin Infect Dis 29: 13151318.[Crossref] [Google Scholar]
  7. Samie A, Barrett LJ, Bessong PO, Ramalivhana JN, Mavhandu LG, Njayou M, Guerrant RL, , 2010. Seroprevalence of Entamoeba histolytica in the context of HIV and AIDS: the case of Vhembe district, in South Africa's Limpopo province. Ann Trop Med Parasitol 104: 5563.[Crossref] [Google Scholar]
  8. Stauffer W, Abd-Alla M, Ravdin JI, , 2006. Prevalence and incidence of Entamoeba histolytica infection in South Africa and Egypt. Arch Med Res 37: 266269.[Crossref] [Google Scholar]
  9. Tsai JJ, Sun HY, Ke LY, Tsai KS, Chang SY, Hsieh SM, Hsiao CF, Yen JH, Hung CC, Chang SC, , 2006. Higher seroprevalence of Entamoeba histolytica infection is associated with human immunodeficiency virus type 1 infection in Taiwan. Am J Trop Med Hyg 74: 10161019. [Google Scholar]
  10. Uga S, Ono K, Kataoka N, Hasan H, , 1996. Seroepidemiology of five major zoonotic parasite infections in inhabitants of Sidoarjo, East Java, Indonesia. Southeast Asian J Trop Med Public Health 27: 556561. [Google Scholar]
  11. Yang B, Chen Y, Wu L, Xu L, Tachibana H, Cheng X, , 2012. Seroprevalence of Entamoeba histolytica infection in China. Am J Trop Med Hyg 87: 97103.[Crossref] [Google Scholar]
  12. del Carmen Sanchez-Guillen M, Velazquez-Rojas M, Salgado-Rosas H, Torres-Rasgado E, Perez-Fuentes R, Martinez-Munguia J, Talamas-Rohana P, , 2000. Seroprevalence of anti-Entamoeba histolytica antibodies by IHA and ELISA assays in blood donors from Puebla, Mexico. Arch Med Res 31: S53S54.[Crossref] [Google Scholar]
  13. Hung CC, Wu PY, Chang SY, Ji DD, Sun HY, Liu WC, Wu CH, Chang SC, , 2011. Amebiasis among persons who sought voluntary counseling and testing for human immunodeficiency virus infection: a case-control study. Am J Trop Med Hyg 84: 6569.[Crossref] [Google Scholar]
  14. Matsumoto T, , 2008. Trends of sexually transmitted diseases and antimicrobial resistance in Neisseria gonorrhoeae . Int J Antimicrob Agents 31 (Suppl 1): S35S39.[Crossref] [Google Scholar]
  15. Suguimoto SP, Techasrivichien T, Musumari PM, El-saaidi C, Lukhele BW, Ono-Kihara M, Kihara M, , 2014. Changing patterns of HIV epidemic in 30 years in east Asia. Curr HIV/AIDS Rep 11: 134145.[Crossref] [Google Scholar]
  16. James R, Barratt J, Marriott D, Harkness J, Stark D, , 2010. Seroprevalence of Entamoeba histolytica infection among men who have sex with men in Sydney, Australia. Am J Trop Med Hyg 83: 914916.[Crossref] [Google Scholar]
  17. Moran P, Ramos F, Ramiro M, Curiel O, Gonzalez E, Valadez A, Gomez A, Garcia G, Melendro EI, Ximenez C, , 2005. Infection by human immunodeficiency virus-1 is not a risk factor for amebiasis. Am J Trop Med Hyg 73: 296300. [Google Scholar]
  18. Fotedar R, Stark D, Beebe N, Marriott D, Ellis J, Harkness J, , 2007. Laboratory diagnostic techniques for Entamoeba species. Clin Microbiol Rev 20: 511532 table of contents. [Google Scholar]
  19. Tanyuksel M, Petri WA, Jr, 2003. Laboratory diagnosis of amebiasis. Clin Microbiol Rev 16: 713729.[Crossref] [Google Scholar]
  20. Nagata N, Shimbo T, Akiyama J, Niikura R, Watanabe K, Oka S, Uemura N, , 2012. Diagnostic accuracy of indirect immunofluorescence assay for intestinal invasive amebiasis and impact of HIV infection in a non-endemic country. Diagn Microbiol Infect Dis 74: 374378.[Crossref] [Google Scholar]
  21. Mithal S, Panigrahi HK, Mohapatra LN, Sunder S, , 1978. Indirect fluorescent antibody test in amoebiasis using axenic Entamoeba histolytica . Indian J Med Res 67: 367373. [Google Scholar]
  22. Ximenez C, Moran P, Rojas L, Valadez A, Gomez A, , 2009. Reassessment of the epidemiology of amebiasis: state of the art. Infect Genet Evol 9: 10231032.[Crossref] [Google Scholar]
  23. Ohnishi K, Kato Y, Imamura A, Fukayama M, Tsunoda T, Sakaue Y, Sakamoto M, Sagara H, , 2004. Present characteristics of symptomatic Entamoeba histolytica infection in the big cities of Japan. Epidemiol Infect 132: 5760.[Crossref] [Google Scholar]
  24. Ohnishi K, Murata M, , 1997. Present characteristics of symptomatic amebiasis due to Entamoeba histolytica in the east-southeast area of Tokyo. Epidemiol Infect 119: 363367.[Crossref] [Google Scholar]
  25. Nagata N, Shimbo T, Akiyama J, Nakashima R, Nishimura S, Yada T, Watanabe K, Oka S, Uemura N, , 2012. Risk factors for intestinal invasive amebiasis in Japan, 2003–2009. Emerg Infect Dis 18: 717724.[Crossref] [Google Scholar]
  26. Watanabe K, Aoki T, Nagata N, Tanuma J, Kikuchi Y, Oka S, Gatanaga H, , 2014. Clinical significance of high anti-Entamoeba histolytica antibody titer in asymptomatic HIV-1-infected individuals. J Infect Dis 209: 18011807.[Crossref] [Google Scholar]
  27. Suzuki J, Kobayashi S, Iku I, Murata R, Yanagawa Y, Takeuchi T, , 2008. Seroprevalence of Entamoeba histolytica infection in female outpatients at a sexually transmitted disease sentinel clinic in Tokyo, Japan. Jpn J Infect Dis 61: 175178. [Google Scholar]
  28. Tandon A, , 1981. Use of enzyme linked immunosorbent assay in intestinal and extra-intestinal amoebiasis (amoebic liver abscess). Trans R Soc Trop Med Hyg 75: 574575.[Crossref] [Google Scholar]
  29. Hira PR, Iqbal J, Al-Ali F, Philip R, Grover S, D'Almeida E, Al-Eneizi AA, , 2001. Invasive amebiasis: challenges in diagnosis in a non-endemic country (Kuwait). Am J Trop Med Hyg 65: 341345. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.16-0134
Loading
/content/journals/10.4269/ajtmh.16-0134
Loading

Data & Media loading...

  • Received : 21 Feb 2016
  • Accepted : 05 May 2016
  • Published online : 07 Sep 2016

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error