1921
Volume 96, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

is the causative agent of melioidosis, an emerging tropical disease of high mortality. Sub-Saharan Africa represents potential melioidosis “hotspots”; however, to date, only a few cases have been reported. Here in, we compared the inflammatory patterns induced by a strain recently isolated from a fatal Gabonese case with the Thai reference strain -1026b and -E264. Ex vivo, no differences were observed in terms of cellular responsiveness between strains. However, when compared with the -1026b strain, the Gabonese isolate was significantly less virulent in terms of bacterial dissemination, inflammatory response, and organ damage in mice. Genomic comparison between strains showed differences in regions containing a fimbriae/adhesion virulence protein. In addition to a lack of microbiology facilities, differences in virulence of strains might contribute to the diverse global clinical occurrence of melioidosis.

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Supplemental Information, Tables, and Figure

  • Received : 16 Feb 2016
  • Accepted : 19 Dec 2016
  • Published online : 13 Mar 2017

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