Volume 95, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We describe two leprosy cases in Mexican siblings caused by a new species . This is likely the first report of family clustering of this infection. The patients showed severe prolonged leprosy reactions after antimicrobial treatment, raising a challenge for clinical management. The current status of infection is reviewed.


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  1. Han XY, Seo YH, Sizer KC, Schoberle T, May GS, Spencer JS, Li W, Nair RG, , 2008. A new Mycobacterium species causing diffuse lepromatous leprosy. Am J Clin Pathol 130: 856864.[Crossref] [Google Scholar]
  2. Han XY, Sizer KC, Thompson EJ, Kabanja J, Li J, Hu P, Gomez-Valero L, Silva FJ, , 2009. Comparative sequence analysis of Mycobacterium leprae and the new leprosy-causing Mycobacterium lepromatosis . J Bacteriol 191: 60676074.[Crossref] [Google Scholar]
  3. Singh P, Benjak A, Schuenemann VJ, . Insight into the evolution and origin of leprosy bacilli from the genome sequence of Mycobacterium lepromatosis . Proc Natl Acad Sci USA 112: 44594464.[Crossref] [Google Scholar]
  4. Han XY, Mistry NA, Thompson EJ, Tang HL, Khanna K, Zhang L, , 2015. Draft genome sequence of new leprosy agent Mycobacterium lepromatosis . Genome Announc 3: e00513-15.[Crossref] [Google Scholar]
  5. Han XY, Sizer KC, Tan HH, , 2012. Identification of the leprosy agent Mycobacterium lepromatosis in Singapore. J Drugs Dermatol 11: 168172. [Google Scholar]
  6. Vera-Cabrera L, Escalante-Fuentes WG, Gomez-Flores M, Ocampo-Candiani J, Busso P, Singh P, Cole ST, , 2011. Case of diffuse lepromatous leprosy associated with “Mycobacterium lepromatosis.” J Clin Microbiol 49: 43664368.[Crossref] [Google Scholar]
  7. Jessamine PG, Desjardins M, Gillis T, Scollard D, Jamieson F, Broukhanski G, Chedore P, McCarthy A, , 2012. Leprosy-like illness in a patient with Mycobacterium lepromatosis from Ontario, Canada. J Drugs Dermatol 11: 229233. [Google Scholar]
  8. Han XY, Sizer KC, Velarde-Felix JS, Frias-Castro LO, Vargas-Ocampo F, , 2012. The leprosy agents Mycobacterium lepromatosis and Mycobacterium leprae in Mexico. Int J Dermatol 51: 952959 [Crossref] [Google Scholar]
  9. Han XY, Jessurun J, , 2013. Severe leprosy reactions due to Mycobacterium lepromatosis . Am J Med Sci 345: 6569.[Crossref] [Google Scholar]
  10. Latapí F, Zamora AC, , 1948. The “spotted” leprosy of Lucio: an introduction to its clinical and histological study. Int J Lepr 16: 421430. [Google Scholar]
  11. Lopez Roa RI, Morris MF, , 2006. Leprosy in Mexico. Nihon Hansenbyo Gakkai Zasshi 75: 5158.[Crossref] [Google Scholar]
  12. Vera-Cabrera L, Escalante-Fuentes W, Ocampo-Garza SS, Ocampo-Candiani J, Molina-Torres CA, Avanzi C, Benjak A, Busso P, Singh P, Cole ST, , 2015. Mycobacterium lepromatosis infections in Nuevo Leon, Mexico. J Clin Microbiol 53: 19451946.[Crossref] [Google Scholar]
  13. Han XY, Quintanilla M, , 2015. Diffuse lepromatous leprosy caused by Mycobacterium lepromatosis in Quintana Roo, Mexico. J Clin Microbiol 53: 36953698.[Crossref] [Google Scholar]
  14. Gelber RH, Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, , 2005. Leprosy (Hansen's disease). , eds. Harrison's Principles of Internal Medicine, 16th edition. New York, NY: McGraw-Hill, 966972. [Google Scholar]
  15. Truman RW, Singh P, Sharma R, Busso P, Rougemont J, Paniz-Mondolfi A, Kapopoulou A, Brisse S, Scollard DM, Gillis TP, Cole ST, , 2011. Probable zoonotic leprosy in the southern United States. N Engl J Med 364: 16261633.[Crossref] [Google Scholar]
  16. Vargas-Ocampo F, , 2007. Diffuse leprosy of Lucio and Latapi: a histologic study. Lepr Rev 78: 248260. [Google Scholar]
  17. Lucio R, Alvarado I, Gonzalez UJ, , 1941 Opusculo sobre el mal de San Lazaro o elefancíasis de los Griegos. , ed. La Lepra en Mexico. Buenos Aires, Argentina: El Ateneo, 199231. [Google Scholar]
  18. Rea TH, Jerskey RS, , 2005. Clinical and histologic variations among thirty patients with Lucio's phenomenon and pure and primitive diffuse lepromatosis (Latapí's lepromatosis). Int J Lepr 73: 169188. [Google Scholar]
  19. Scollard D, Stryjewska B, Baron EL, , 2015. Treatment and prevention of leprosy. , ed. UpToDate. Waltham, MA: UpToDate. [Google Scholar]
  20. Lazaro FP, Werneck RI, Mackert CC, Cobat A, Prevedello FC, Pimentel RP, Macedo GM, Eleuterio MA, Vilar G, Abel L, Xavier MB, Alcais A, Mira MT, , 2010. A major gene controls leprosy susceptibility in a hyperendemic isolated population from north of Brazil. J Infect Dis 201: 15981605.[Crossref] [Google Scholar]
  21. Sapkota BR, Macdonald M, Berrington WR, Misch EA, Ranjit C, Siddiqui MR, Kaplan G, Hawn TR, , 2010. Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes. Hum Immunol 71: 992998.[Crossref] [Google Scholar]

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  • Received : 01 Feb 2016
  • Accepted : 17 May 2016
  • Published online : 07 Sep 2016

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