Volume 95, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Histoplasmosis, caused by the dimorphic fungus , is a disease of protean manifestations and of global distribution. Although increasingly reported in Asia, there are few reports from the Philippines. Here, we describe a case of microbiologically diagnosed histoplasmosis, probably acquired from the Philippines, in a returning traveler who presented with a right foot wound and papular rash. The final diagnosis was disseminated histoplasmosis with cutaneous and bone involvement, both unusual manifestations of the disease.


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  1. Bahr NC, Antinori S, Wheat LJ, Sarosi GA, , 2015. Histoplasmosis infections worldwide: thinking outside of the Ohio River valley. Curr Trop Med Rep 2: 7080.[Crossref] [Google Scholar]
  2. Norkaew T, Ohno H, Sriburee P, Tanabe K, Tharavichitkul P, Takarn P, Puengchan T, Bumrungsri S, Miyazaki Y, , 2013. Detection of environmental sources of Histoplasma capsulatum in Chiang Mai, Thailand, by nested PCR. Mycopathologia 176: 395402.[Crossref] [Google Scholar]
  3. Pan B, Chen M, Pan W, Liao W, , 2013. Histoplasmosis: a new endemic fungal infection in China? Review and analysis of cases. Mycoses 56: 212221.[Crossref] [Google Scholar]
  4. Randhawa HS, , 1970. Occurrence of histoplasmosis in Asia. Mycopathol Mycol Appl 41: 7589.[Crossref] [Google Scholar]
  5. Sethi KK, Passi S, , 1970. Histoplasmosis in India. A critical review. Mycopathol Mycol Appl 40: 369374.[Crossref] [Google Scholar]
  6. Bulmer AC, Bulmer GS, , 2001. Incidence of histoplasmin hypersensitivity in the Philippines. Mycopathologia 149: 6971.[Crossref] [Google Scholar]
  7. Navarro EE, Tupasi TE, Verallo VM, Romero RC, Tuazon CU, , 1992. Disseminated histoplasmosis with unusual cutaneous lesions in a patient from the Philippines. Am J Trop Med Hyg 46: 141145. [Google Scholar]
  8. Palencia RJ, Aniceto EG, Pena AC, , 1990. Fever of unknown origin with hepatomegaly due to Histoplasma capsulatum: case report. Phil J Microbiol Infect Dis 19: 6367. [Google Scholar]
  9. Mendoza S, , 1947. Histoplasmosis. Report of a case. Monthly Bull Bur Health 23: 3340. [Google Scholar]
  10. Natividad-Santos E, , 1974. A case of progressive disseminated histoplasmosis. Chest Dis 9: 1519. [Google Scholar]
  11. Hilda L-K, , 1981. Disseminated histoplasmosis in a two month old Filipino infant: a preliminary report. Phil J Microbiol Infect Dis 10: 124130. [Google Scholar]
  12. Wheat LJ, Slama TG, Norton JA, Kohler RB, Eitzen HE, French ML, Sathapatayavongs B, , 1982. Risk factors for disseminated or fatal histoplasmosis. Analysis of a large urban outbreak. Ann Intern Med 96: 159163.[Crossref] [Google Scholar]
  13. Eidbo J, Sanchez RL, Tschen JA, Ellner KM, , 1993. Cutaneous manifestations of histoplasmosis in the acquired immune deficiency syndrome. Am J Surg Pathol 17: 110116.[Crossref] [Google Scholar]
  14. Karimi K, Wheat LJ, Connolly P, Cloud G, Hajjeh R, Wheat E, Alves K, Lacaz C da S, Keath E, , 2002. Differences in histoplasmosis in patients with acquired immunodeficiency syndrome in the United States and Brazil. J Infect Dis 186: 16551660.[Crossref] [Google Scholar]
  15. Chakrabarti A, Slavin MA, , 2011. Endemic fungal infections in the Asia-Pacific region. Med Mycol 49: 337344.[Crossref] [Google Scholar]
  16. Huang L, Wu Y, Miao X, , 2013. Localized Histoplasma capsulatum osteomyelitis of the fibula in an immunocompetent teenage boy: a case report. BMC Infect Dis 13: 132.[Crossref] [Google Scholar]
  17. McCabe MP, Heck RK, , 2010. Histoplasma osteomyelitis simulating giant-cell tumor of the distal part of the radius: a case report. J Bone Joint Surg Am 92: 708714.[Crossref] [Google Scholar]
  18. Assi MA, Sandid MS, Baddour LM, Roberts GD, Walker RC, , 2007. Systemic histoplasmosis: a 15-year retrospective institutional review of 111 patients. Medicine (Baltimore) 86: 162169.[Crossref] [Google Scholar]
  19. Williams AO, Lawson EA, Lucas AO, , 1971. African histoplasmosis due to Histoplasma duboisii . Arch Pathol 92: 306318. [Google Scholar]
  20. Wheat LJ, Freifeld AG, Kleiman MB, Baddley JW, McKinsey DS, Loyd JE, Kauffman CA, Infectious Diseases Society of America, , 2007. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 45: 807825.[Crossref] [Google Scholar]
  21. Zerbe CS, Holland SM, , 2005. Disseminated histoplasmosis in persons with interferon-gamma receptor 1 deficiency. Clin Infect Dis 41: e38e41.[Crossref] [Google Scholar]
  22. Wang TL, Cheah JS, Holmberg K, , 1996. Case report and review of disseminated histoplasmosis in south-east Asia: clinical and epidemiological implications. Trop Med Int Health 1: 3542.[Crossref] [Google Scholar]
  23. Rosenstein NE, Emery KW, Werner SB, Kao A, Johnson R, Rogers D, Vugia D, Reingold A, Talbot R, Plikaytis BD, Perkins BA, Hajjeh RA, , 2001. Risk factors for severe pulmonary and disseminated coccidioidomycosis: Kern County, California, 1995–1996. Clin Infect Dis 32: 708715.[Crossref] [Google Scholar]

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  • Received : 28 Jan 2016
  • Accepted : 22 Feb 2016
  • Published online : 06 Jul 2016

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