1921
Volume 95, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

infections are widespread and highly prevalent in rodents. Several rodent-associated species have been related to human diseases. Recently, species was reported as the etiology of a human case in the country of Georgia (Caucasus). However, information on in rodents in Georgia is absent. Rodent hearts were collected from Georgia to investigate the presence and diversity of species. bacteria were cultured from 37.2% (16/43) of rodents examined, while DNA was detected in 41.2% (28/68) of rodents by polymerase chain reaction targeting citrate synthase () gene. Sequences of showed that rodents in this region harbored multiple strains, including , , , and an unknown genogroup. The first three species, known to be rat-associated and human cases linked, were commonly observed in wood mice ( [] ) (5/8 positive with and ) and social voles () (4/6 positive with and ) in this study. The frequent distribution of these species suggests that they may contribute to unidentified clinical infections. The unknown genogroup was observed in 24 isolates and/or DNA extracts from heart tissues, all of which were obtained from (). Further characterization of the bacterial cultures based on sequence analysis of four additional genes (, , , and ) supported that the jird-associated strains comprise a distinct monophyletic clade. The impact of this bacterium on wildlife and human health needs to be determined.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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2017-09-24
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References

  1. Dehio C, , 2001. Bartonella interactions with endothelial cells and erythrocytes. Trends Microbiol 9: 279285.[Crossref]
  2. Birtles RJ, Harrison TG, Molyneux DH, , 1994. Grahamella in small woodland mammals in the U.K.–isolation, prevalence and host-specificity. Ann Trop Med Parasitol 88: 317327.[Crossref]
  3. Ying B, Kosoy MY, Maupin GO, Tsuchiya KR, Gage KL, , 2002. Genetic and ecologic characteristics of Bartonella communities in rodents in southern China. Am J Trop Med Hyg 66: 622627.
  4. Bai Y, Calisher CH, Kosoy MY, Root JJ, Doty JB, , 2011. Persistent infection or successive reinfection of deer mice with Bartonella vinsonii subsp. arupensis . Appl Environ Microbiol 77: 17281731.[Crossref]
  5. Bai Y, Malania L, Castillo DA, Moran D, Boonmar S, Chanlun A, Suksawat F, Maruyama S, Knobel D, Kosoy M, , 2013. Global distribution of Bartonella infections in domestic bovine and characterization of Bartonella bovis strains using multi-locus sequence typing. PLoS One 8: e80894.[Crossref]
  6. Welch DF, Pickett DA, Slater LN, Steigerwalt AG, Brenner DJ, , 1992. Rochalimaea henselae sp. nov., a cause of septicemia, bacillary angiomatosis, and parenchymal bacillary peliosis. J Clin Microbiol 30: 275280.
  7. Daly JS, Worthington MG, Brenner DJ, Moss CW, Hollis DG, Weyant RS, Steigerwalt AG, Weaver RE, Daneshvar MI, O'Connor SP, , 1993. Rochalimaea elizabethae sp. nov. isolated from a patient with endocarditis. J Clin Microbiol 31: 872881.
  8. Anderson BE, Neuman MA, , 1997. Bartonella spp. as emerging human pathogens. Clin Microbiol Rev 10: 203219.
  9. Kerkhoff FT, Bergmans AM, van Der Zee A, Rothova A, , 1999. Demonstration of Bartonella grahamii DNA in ocular fluids of a patient with neuroretinitis. J Clin Microbiol 37: 40344038.
  10. Welch DF, Carroll KC, Hofmeister EK, Persing DH, Robison DA, Steigerwalt AG, Brenner DJ, , 1999. Isolation of a new subspecies, Bartonella vinsonii subsp. arupensis, from a cattle rancher: identity with isolates found in conjunction with Borrelia burgdorferi and Babesia microti among naturally infected mice. J Clin Microbiol 37: 25982601.
  11. Kosoy M, Murray M, Gilmore RD, Jr Bai Y, Gage KL, , 2003. Bartonella strains from ground squirrels are identical to Bartonella washoensis isolated from a human patient. J Clin Microbiol 41: 645650.[Crossref]
  12. Kosoy M, Bai Y, Sheff K, Morway C, Baggett H, Maloney SA, Boonmar S, Bhengsri S, Dowell SF, Sitdhirasdr A, Lerdthusnee K, Richardson J, Peruski LF, , 2010. Identification of Bartonella infections in febrile human patients from Thailand and their potential animal reservoirs. Am J Trop Med Hyg 82: 11401145.[Crossref]
  13. Chomel BB, Boulouis HJ, Breitschwerdt EB, , 2004. Cat scratch disease and other zoonotic Bartonella infections. J Am Vet Med Assoc 224: 12701279.[Crossref]
  14. Castle K, Kosoy M, Lerdthusnee K, Phelan L, Bai Y, Gage KL, Leepitakrat W, Monkanna T, Khlaimanee N, Chandranoi K, Jones JW, Coleman RE, , 2004. Prevalence and diversity of Bartonella in rodents of northern Thailand: a comparison with Bartonella in rodents from southern China. Am J Trop Med Hyg 70: 429433.
  15. Pretorius AM, Beati L, Birtles RJ, , 2004. Diversity of Bartonellae associated with small mammals inhabiting free state province, South Africa. Int J Syst Evol Microbiol 54: 19591967.[Crossref]
  16. Jardine C, Appleyard G, Kosoy MY, McColl D, Chirino-Trejo M, Wobeser G, Leighton FA, , 2005. Rodent-associated Bartonella in Saskatchewan, Canada. Vector Borne Zoonotic Dis 5: 402409.[Crossref]
  17. Bai Y, Montgomery SP, Sheff KW, Chowdhury MA, Breiman RF, Kabeya H, Kosoy MY, , 2007. Bartonella strains in small mammals from Dhaka, Bangladesh, related to Bartonella in America and Europe. Am J Trop Med Hyg 77: 567570.
  18. Inoue K, Maruyama S, Kabeya H, Yamada N, Ohashi N, Sato Y, Yukawa M, Masuzawa T, Kawamori F, Kadosaka T, Takada N, Fujita H, Kawabata H, , 2008. Prevalence and genetic diversity of Bartonella species isolated from wild rodents in Japan. Appl Environ Microbiol 74: 50865092.[Crossref]
  19. Bai Y, Kosoy MY, Lerdthusnee K, Peruski LF, Richardson JH, , 2009. Prevalence and genetic heterogeneity of Bartonella strains cultured from rodents from 17 provinces in Thailand. Am J Trop Med Hyg 81: 811816.[Crossref]
  20. Gundi VA, Taylor C, Raoult D, La Scola B, , 2009. Bartonella rattaustraliani sp. nov., Bartonella queenslandensis sp. nov. and Bartonella coopersplainsensis sp. nov., identified in Australian rats. Int J Syst Evol Microbiol 59: 29562961.[Crossref]
  21. Gundi VA, Billeter SA, Rood MP, Kosoy MY, , 2012. Bartonella spp. in rats and zoonoses, Los Angeles, California, USA. Emerg Infect Dis 18: 631633.[Crossref]
  22. Halliday JE, Knobel DL, Agwanda B, Bai Y, Breiman RF, Cleaveland S, Njenga MK, Kosoy M, , 2015. Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya. PLoS Negl Trop Dis 9: e0003608.[Crossref]
  23. Harrus S, Bar-Gal GK, Golan A, Elazari-Volcani R, Kosoy MY, Morick D, Avidor B, Baneth G, , 2009. Isolation and genetic characterization of a Bartonella strain closely related to Bartonella tribocorum and Bartonella elizabethae in Israeli commensal rats. Am J Trop Med Hyg 81: 5558.
  24. Kim KS, Inoue K, Kabeya H, Sato S, Takada T, Pangjai D, Chiu SH, Fujita H, Kawabata H, Takada N, Kariwa H, Maruyama S, , 2016. Prevalence and diversity of Bartonella species in wild small mammals in Asia. J Wildl Dis 52: 1021.[Crossref]
  25. Kandelaki G, Malania L, Bai Y, Chakvetadze N, Katsitadze G, Imnadze P, Nelson C, Harrus S, Kosoy M, , 2016. Human lymphadenopathy caused by a ratborne Bartonella strain, Tbilisi, Country of Georgia. Emerg Infect Dis 22: 544546.[Crossref]
  26. Norman AF, Regnery R, Jameson P, Greene C, Krause DC, , 1995. Differentiation of Bartonella-like isolates at the species level by PCR-restriction fragment length polymorphism in the citrate synthase gene. J Clin Microbiol 33: 17971803.
  27. Chaloner GL, Ventosilla P, Birtles RJ, , 2011. Multi-locus sequence analysis reveals profound genetic diversity among isolates of the human pathogen Bartonella bacilliformis . PLoS Negl Trop Dis 7: e1248.[Crossref]
  28. Inoue K, Maruyama S, Kabeya H, Hagiya K, Izumi Y, Une Y, Yoshikawa Y, , 2009. Exotic small mammals as potential reservoirs of zoonotic Bartonella spp. Emerg Infect Dis 15: 526532.[Crossref]
  29. Morick D, Krasnov BR, Khokhlova IS, Shenbrot GI, Kosoy MY, Harrus S, , 2010. Bartonella genotypes in fleas (insecta: siphonaptera) collected from rodents in the Negev Desert, Israel. Appl Environ Microbiol 76: 68646869.[Crossref]
  30. Morick D, Krasnov BR, Khokhlova IS, Gottlieb Y, Harrus S, , 2011. Investigation of Bartonella acquisition and transmission in Xenopsylla ramesis fleas (Siphonaptera: Pulicidae). Mol Ecol 20: 28642870.[Crossref]
  31. La Scola B, Liang Z, Zeaiter Z, Houpikian P, Grimont PA, Raoult D, , 2002. Genotypic characteristics of two serotypes of Bartonella henselae . J Clin Microbiol 40: 20022008.[Crossref]
  32. Birtles RJ, Raoult D, , 1996. Comparison of partial citrate synthase gene (gltA) sequences for phylogenetic analysis of Bartonella species. Int J Syst Bacteriol 46: 891897.[Crossref]
  33. Comer JA, Flynn C, Regnery RL, Vlahov D, Childs JE, , 1996. Antibodies to Bartonella species in inner-city intravenous drug users in Baltimore, MD. Arch Intern Med 156: 24912495.[Crossref]
  34. O'Halloran HS, Draud K, Minix M, Rivard AK, Pearson PA, , 1998. Leber's neuroretinitis in a patient with serologic evidence of Bartonella elizabethae . Retina 18: 276278.[Crossref]
  35. Heller R, Riegel P, Hansmann Y, Delacour G, Bermond D, Dehio C, Lamarque F, Monteil H, Chomel B, Piémont Y, , 1998. Bartonella tribocorum sp. nov., a new Bartonella species isolated from the blood of wild rats. Int J Syst Bacteriol 48: 13331339.[Crossref]
  36. Ellis BA, Regnery RL, Beati L, Bacellar F, Rood M, Glass GG, Marston E, Ksiazek TG, Jones D, Childs JE, , 1999. Rats of the genus Rattus are reservoir hosts for pathogenic Bartonella species: an Old World origin for a New World disease? J Infect Dis 180: 220224.[Crossref]
  37. Mediannikov O, Ivanov L, Zdanovskaya N, Vysochina N, Fournier PE, Tarasevich I, Raoult D, , 2005. Molecular screening of Bartonella species in rodents from the Russian far east. Ann N Y Acad Sci 1063: 308311.[Crossref]
  38. Kosoy M, Hayman DT, Chan KS, , 2012. Bartonella bacteria in nature: where does population variability end and a species start? Infect Genet Evol 12: 894904.[Crossref]
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  • Received : 14 Jan 2016
  • Accepted : 12 Mar 2016

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