1921
Volume 95, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Herein, we report a case of fatal melioidosis in a newborn. The newborn died of serious melioidosis with respiratory and multiorgan failure at 16 days of age despite extensive treatment with antibiotics and methylprednisolone. was isolated from the infant's blood and cerebrospinal fluid and identified as a novel sequence type (ST-1341). His father had cough and fever when the newborn was born, and a localized patchy infiltration on the right upper lung was seen in chest radiography, but was not isolated. Two years later, the father developed cough and fever again, and the same novel sequence type of was isolated from the blood of the father. It is postulated that transmission of from the father to the newborn might have occurred during close contact in the first couple of days after birth. Given the high mortality of neonatal melioidosis, particular attention must be paid when the caretakers of the newborn develop fever of unknown origin in a melioidosis-endemic region.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.15-0899
2016-08-03
2017-11-19
Loading full text...

Full text loading...

/deliver/fulltext/14761645/95/2/444.html?itemId=/content/journals/10.4269/ajtmh.15-0899&mimeType=html&fmt=ahah

References

  1. Limmathurotsakul D, Dance DA, Wuthiekanun V, Kaestli M, Mayo M, Warner J, Wagner DM, Tuanyok A, Wertheim H, Yoke Cheng T, Mukhopadhyay C, Puthucheary S, Day NP, Steinmetz I, Currie BJ, Peacock SJ, , 2013. Systematic review and consensus guidelines for environmental sampling of Burkholderia pseudomallei . PLoS Negl Trop Dis 7: e2105.[Crossref]
  2. Zhang W, Wang L, Liu Y, Chen X, Liu Q, Jia J, Yang T, Qiu S, Ma G, , 2014. Immune responses to vaccines involving a combined antigen-nanoparticle mixture and nanoparticle-encapsulated antigen formulation. Biomaterials 35: 60866097.[Crossref]
  3. Fang Y, Chen H, Li YL, Li Q, Ye ZJ, Mao XH, , 2015. Melioidosis in Hainan, China: a retrospective study. Trans R Soc Trop Med Hyg 109: 636642.[Crossref]
  4. Yang S, , 2000. Melioidosis research in China. Acta Trop 77: 157165.[Crossref]
  5. Abbink FC, Orendi JM, de Beaufort AJ, , 2001. Mother-to-child transmission of Burkholderia pseudomallei . N Engl J Med 344: 11711172.[Crossref]
  6. Michelle Wong Su Y, Lisanti O, Thibault F, Toh Su S, Loh Gek K, Hilaire V, Jiali L, Neubauer H, Vergnaud G, Ramisse V, , 2009. Validation of ten new polymorphic tandem repeat loci and application to the MLVA typing of Burkholderia pseudomallei isolates collected in Singapore from 1988 to 2004. J Microbiol Methods 77: 297301.[Crossref]
  7. Lumbiganon P, Pengsaa K, Puapermpoonsiri S, Puapairoj A, , 1988. Neonatal melioidosis: a report of 5 cases. Pediatr Infect Dis J 7: 634636.[Crossref]
  8. Lumbiganon P, Viengnondha S, , 1995. Clinical manifestations of melioidosis in children. Pediatr Infect Dis J 14: 136140.[Crossref]
  9. Saipan P, , 1998. Neurological manifestations of melioidosis in children. Southeast Asian J Trop Med Public Health 29: 856859.
  10. Foong YW, Tan NW, Chong CY, Thoon KC, Tee NW, Koh MJ, , 2015. Melioidosis in children: a retrospective study. Int J Dermatol 54: 929938.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.15-0899
Loading
/content/journals/10.4269/ajtmh.15-0899
Loading

Data & Media loading...

  • Received : 14 Dec 2015
  • Accepted : 09 Apr 2016

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error