1921
Volume 95, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Hepatitis B virus (HBV) infection accounts for about 1 million deaths worldwide annually. This study was to determine the prevalence, distribution of HBV, and factors associated with infection in an apparently healthy population in Nigeria. A cross-sectional study among the general population was conducted employing a multistage sampling technique. Data on demographic, social, and behavioral indicators were collected using questionnaires and blood samples tested for HBV seromarkers. Descriptive, bivariate, and multivariate analyses were done. Prevalence of hepatitis B infection was 12.2% (confidence interval [CI] = 10.3–14.5). Of the participants, more than half, 527 (54.6%), had evidence of previous exposure to HBV, while 306 (31.7%) showed no serologic evidence of infection or vaccination. Only 76 (7.9%) participants showed serologic evidence of immunity to HBV through vaccination. Factors associated with testing positive for HBV infection were dental procedure outside the health facility (odds ratios [OR] = 3.4, 95% CI = 1.52–7.70), local circumcision (OR = 1.73, 95% CI = 1.17–2.57), and uvulectomy (OR = 1.65, 95% CI = 1.06–2.57). With logistic regression, only dental procedure outside the health facility (adjusted OR = 3.32, 95% CI = 1.38–7.97) remained significant. This first national survey on seroprevalence of hepatitis B describes the epidemiology and high prevalence of HBV infection in Nigeria and highlights the need for improved vaccination against HBV.

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2016-10-05
2017-11-25
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References

  1. Ganem D, Prince AM, , 2004. Hepatitis B virus infection—natural history and clinical consequences. N Engl J Med 350: 11181129.[Crossref]
  2. Lok ASF, McMahon BJ, , 2007. Chronic hepatitis B. Hepatology 45: 507539.[Crossref]
  3. WHO, 2014. Hepatitis B. Available at: http://www.who.inf/inf-s/en/fact204.html. Accessed July 28, 2013.
  4. Kramvis A, Kew M, , 2007. Epidemiology of hepatitis B virus in Africa, its genotypes and clinical associations of genotypes. Hepatol Res 37 (Suppl 1): 919.[Crossref]
  5. Apurva AM, Jordan JF, , 2007. Viral hepatitis and HIV in Africa. AIDS Rev 9: 2539.
  6. Hou J, Liu Z, Gu F, , 2005. Epidemiology and prevention of hepatitis B virus infection. Int J Med Sci 2: 5057.[Crossref]
  7. Gray Davis L, Weber DJ, Lemon SM, , 1989. Horizontal transmission of hepatitis B virus. Lancet 1: 889893.[Crossref]
  8. Belo AC, , 2000. Prevalence of hepatitis B virus markers in surgeons in Lagos, Nigeria. East Afr Med J 77: 283285.
  9. Chang MH, , 2000. Natural history of hepatitis B virus infection in children. J Gastroenterol Hepatol 15: 1619.[Crossref]
  10. Sofola OO, Folayan MO, Denloye OO, Okeigbemen SA, , 2007. Occupational exposure to bloodborne pathogens and management of exposure incidents in Nigerian dental schools. J Dent Educ 71: 832837.
  11. Bhattarai S, Smriti KC, Pradhan PM, Lama S, Rijal S, , 2014. Hepatitis B vaccination status and needle-stick and sharps-related injuries among medical school students in Nepal: a cross-sectional study. BMC Res Notes 7: 774.[Crossref]
  12. Mahoney FJ, Kane M, Plotkin SA, Orenstein WA, , 1999. Hepatitis B vaccine. , eds. Vaccines, 3rd edition. Philadelphia, PA: W.B. Saunders Company, 158182.
  13. Ott JJ, Stevens GA, Groeger J, Wiersma ST, , 2012. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 30: 22122219.[Crossref]
  14. Harry TO, Bajani MD, Moses AE, , 1994. Hepatitis B virus infection among blood donors and pregnant women in Maiduguri, Nigeria. East Afr Med J 70: 596597.
  15. Akani CI, Ojule AC, Opurum HC, Ejilemele AA, , 2005. Seroprevalence of HBsAg in pregnant women in Port Harcourt. Niger Postgrad Med J 12: 266270.
  16. Agbede OO, Iseniyi JO, Kolewale MO, Ojuawo A, , 2007. Risk factors and seroprevalence of hepatitis B antigenemia in mothers and their preschool children in Ilorin, Nigeria. Therapy 4: 6772.[Crossref]
  17. Luka SA, Ibrahim MB, Iliya SN, , 2008. Seroprevalence of hepatitis B surface antigen among pregnant women attending Ahmadu Bello University Teaching Hospital Zaria. Niger J Parasitol 29: 3841.
  18. Forbi JC, Onyemauwa N, Gyar SD, Oyeleye AO, Entonu P, Agwale SM, , 2008. High prevalence of hepatitis B virus among female sex workers in Nigeria. Rev Inst Med Trop Sao Paulo 50: 219221.[Crossref]
  19. Olokoba AB, Salawu FK, Danburam A, Desalu OO, Olokoba LB, Wahab KW, , 2009. Viral hepatitis in voluntary blood donors in Yola, Nigeria. Euro J Scientific Res 31: 329334.
  20. Minuk GY, Cohen AJ, Assy N, Moser M, , 2005. Viral hepatitis and the surgeon. HPB (Oxford) 7: 5664.[Crossref]
  21. National Programme on Immunization and Partners, 2002. Five Years National Strategic Plan 2003–2007. Abuja, Nigeria: National Programme on Immunization, 1920.
  22. GAVI, 2015. Nigeria Launches Pentavalent Vaccine. Available at: http://www.gavi.org/Library/News/GAVI-features/2012/Nigeria-launches-pentavalent-vaccine/. Accessed June 24, 2015.
  23. Bwogi J, Braka F, Makumbi I, Mishra V, Bakamutumaho B, Nanyunja M, Opio A, Downing R, Biryahwaho B, Lewis RF, , 2009. Hepatitis B infection is highly endemic in Uganda: findings from a national serosurvey. Afr Health Sci 9: 98108.
  24. Center for Disease Control and Prevention Finelli L, Bell BP, , 2012. Chapter 4: Hepatitis B. , eds. Manual for the Surveillance of Vaccine Preventable Diseases. Available at: www.cdc.gov/vaccines/pubs/surv-manual/chpt04-hepb.html. Accessed July 7, 2012.
  25. Osifo OD, Ovueni ME, , 2009. Current views, level of acceptance, and practice of male circumcision in Africa subregion. Ann Pediatr Surg 5: 254260.
  26. Abdur-Rahman LO, Musa OI, Oshagbemi GK, , 2012. Community-based study of circumcision practices in Nigeria. Ann Trop Med Public Health 5: 231235.[Crossref]
  27. Kiire CF, African Regional Study Group, , 1990. Hepatitis B infection in sub-Saharan Africa. Vaccine 8 (Suppl 1): 107112.[Crossref]
  28. Martinson FEA, Weigle KA, Royce RA, , 1998. Risk factors for horizontal transmission of hepatitis B in a rural district in Ghana. Am J Epidemiol 147: 478487.[Crossref]
  29. Burnett RJ, Francois G, Kew MC, , 2005. Hepatitis B virus and human immunodeficiency virus co-infection in sub Saharan Africa: a call for further investigation. Liver Int 25: 201213.[Crossref]
  30. Vilibić-Cavlek T, Kucinar J, Ljubin-Sternak S, Kaić B, Lazarić-Stefanović L, Kolarić B, , 2014. Prevalence of viral hepatitis in Croatian adult population undergoing routine check-up, 2010–2011. Cent Eur J Public Health 22: 2933.[Crossref]
  31. Yamada H, Fujimoto M, Svay S, Lim O, Hok S, Goto N, Ohisa M, Akita T, Matsuo J, Do SH, Katayama K, Miyakawa Y, Tanaka J, , 2014. Seroprevalence, genotypic distribution and potential risk factors of hepatitis B and C virus infections among adults in Siem Reap, Cambodia. Hepatol Res 45: 480487.[Crossref]
  32. Edris A, Nour MO, Zedan OO, Mansour AE, Ghandour AA, Omran T, , 2014. Seroprevalence and risk factors for hepatitis B and C virus infection in Damietta Governorate, Egypt. East Mediterr Health J 20: 605613.
  33. Aminu M, Okachi EE, Abubakar SM, Yahaya A, , 2013. Prevalence of hepatitis B virus surface antigen among healthy asymptomatic students in a Nigerian University. Ann Afr Med 12: 5556.[Crossref]
  34. Eroglu C, Zivalioglu M, Esen S, Sunbul M, Leblebicioglu H, , 2010. Detection of hepatitis B virus in used razor blades by PCR. Hepat Mon 10: 2225.
  35. Black AP, Nouanthong P, Nanthavong N, Souvannaso C, Vilivong K, Jutavijittum P, Samountry B, Lütteke N, Hübschen JM, Goossens S, Quet F, Buisson Y, Muller CP, , 2014. Hepatitis B virus in the Lao People's Democratic Republic: a cross sectional serosurvey in different cohorts. BMC Infect Dis 14: 457460.[Crossref]
  36. Nguyen TT, McPhee SJ, Stewart S, Gildengorin G, Zhang L, Wong C, , 2010. Factors associated with hepatitis B testing among Vietnamese Americans. J Gen Intern Med 25: 694700.[Crossref]
  37. Ogoina D, Pondei K, Adetunji B, , 2014. Prevalence of hepatitis B vaccination among health care workers in Nigeria in 2011–12. Int J Occup Environ Med 5: 5156.
  38. Adebamowo CA, Odukogbe AA, Ajuwon AJ, , 1998. Knowledge, attitude, and practices related to hepatitis B virus infection among Nigerian obstetricians and midwives. J Obstet Gynaecol 18: 528532.[Crossref]
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  • Received : 02 Dec 2015
  • Accepted : 31 May 2016

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