Volume 95, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Measurements of CD4CD31 cells gave results consistent with those expected for recent thymus emigrant (RTE) CD4 cells. The method was markedly simpler than established procedures for measurement of CD4 RTE cells and is usable in locations with limited facilities and budgets.


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  1. Li T, Wu N, Dai Y, Qiu Z, Han Y, Xie J, Zhu T, Li Y, , 2011. Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy. Clin Infect Dis 53: 944951.[Crossref] [Google Scholar]
  2. Resino S, Galan I, Perez A, Leon JA, Seoane E, Gurbindo D, Muñoz-Fernandez MA, , 2004. HIV-infected children with moderate/severe immune-suppression: changes in the immune system after highly active antiretroviral therapy. Clin Exp Immunol 137: 570577.[Crossref] [Google Scholar]
  3. De Rossi A, Walker AS, Klein N, De Forni D, King D, Gibb DM, , 2002. Increased thymic output after initiation of antiretroviral therapy in human immunodeficiency virus type 1-infected children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 Trial. J Infect Dis 186: 312320.[Crossref] [Google Scholar]
  4. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA, , 1998. Changes in thymic function with age and during the treatment of HIV infection. Nature 396: 690695.[Crossref] [Google Scholar]
  5. Kimmig S, Przybylski GK, Schmidt CA, Laurisch K, Mowes B, Radbruch A, Thiel A, , 2002. Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J Exp Med 195: 789794.[Crossref] [Google Scholar]
  6. Junge S, Kloeckener-Gruissem B, Zufferey R, Keisker A, Salgo B, Fauchere JC, Scherer F, Shalaby T, Grotzer M, Siler U, Seger R, Güngör T, , 2007. Correlation between recent thymic emigrants and CD31+ (PECAM-1) CD4+ T cells in normal individuals during aging and in lymphopenic children. Eur J Immunol 37: 32703280.[Crossref] [Google Scholar]
  7. Tanaskovic S, Fernandez S, Price P, Lee S, French MA, , 2010. CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or γδ T-cells, in HIV patients responding to ART. Immunol Cell Biol 88: 321327.[Crossref] [Google Scholar]
  8. Klein N, Sefe D, Mosconi I, Zanchetta M, Castro H, Jacobsen M, Jones H, Bernardi S, Pillay D, Giaquinto C, Walker AS, Gibb DM, De Rossi A, Paediatric European Network for Treatment of AIDS 11 Trial Team, , 2013. The immunological and virological consequences of planned treatment interruptions in children with HIV infection. PLoS One 8: e76582.[Crossref] [Google Scholar]
  9. Blanche S, Scott-Algara D, Le Chenadec J, Didier C, Montange T, Avettand-Fenoel V, Rouzioux C, Mélard A, Viard JP, Dollfus C, Bouallag N, Warszawski J, Buseyne F, , 2014. Naive T lymphocytes and recent thymic emigrants are associated with HIV-1 disease history in French adolescents and young adults infected in the perinatal period: the ANRS-EP38-IMMIP study. Clin Infect Dis 58: 573587.[Crossref] [Google Scholar]
  10. Rallon N, Sempere-Ortells JM, Soriano V, Benito JM, , 2013. Central memory CD4 T cells are associated with incomplete restoration of the CD4 T cell pool after treatment-induced long-term undetectable HIV viraemia. J Antimicrob Chemother 68: 26162625.[Crossref] [Google Scholar]
  11. Pido-Lopez J, Imami N, Aspinall R, , 2001. Both age and gender affect thymic output: more recent thymic migrants in females than males as they age. Clin Exp Immunol 125: 409413.[Crossref] [Google Scholar]
  12. Resino S, Resino R, Micheloud D, Gurbindo Gutierrez D, Leon JA, Ramos JT, Ciria L, de José I, Mellado J, Muñoz-Fernández A, Spanish Group of Paediatric HIV Infection, , 2006. Long-term effects of highly active antiretroviral therapy in pretreated, vertically HIV type 1-infected children: 6 years of follow-up. Clin Infect Dis 42: 862869.[Crossref] [Google Scholar]
  13. Huenecke S, Behl M, Fadler C, Zimmermann SY, Bochennek K, Tramsen L, Esser R, Klarmann D, Kamper M, Sattler A, von Laer D, Klingebiel T, Lehrnbecher T, Koehl U, , 2008. Age-matched lymphocyte subpopulation reference values in childhood and adolescence: application of exponential regression analysis. Eur J Haematol 80: 532539.[Crossref] [Google Scholar]

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  • Received : 23 Oct 2015
  • Accepted : 28 Jun 2016
  • Published online : 05 Oct 2016

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