1921
Volume 97, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The Guillain–Barré syndrome (GBS) has been reported as a possible complication of acute chikungunya infection. The chikungunya epidemics, which occurred in Martinique and Guadeloupe in 2014, affected 308,000 people in these two islands. GBS occurred during or immediately after acute chikungunya infection in 13 patients (10 men, three women; mean age: 61 years). Median time from acute chikungunya to GBS onset was 9 days. Twelve patients were treated with intravenous polyvalent immunoglobulins, nine of whom improved within 7 days. Five of 13 patients required mechanical ventilation. Two patients with severe GBS died. At 6 months of follow-up, 7/13 achieved a good functional recovery with no or minor residual symptoms. A 2-fold increase in incidence was observed during the year of chikungunya outbreak. This study supports prior reports suggesting that GBS may be a complication of chikungunya.

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2017-08-02
2018-08-19
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References

  1. Cassadou S, Boucau S, Petit-Sinturel M, Huc P, Leparc-Goffart I, Ledrans M, , 2014. Emergence of chikungunya fever on the French side of Saint Martin island, October to December 2013. Euro Surveill 19: 13.[Crossref]
  2. Thiberville S-D, Moyen N, Dupuis-Maguiraga L, Nougairede A, Gould EA, Roques P, de Lamballerie X, , 2013. Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy. Antiviral Res 99: 345370.[Crossref]
  3. van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA, , 2014. Guillain-Barre syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol 10: 469482.[Crossref]
  4. van Doorn PA, Ruts L, Jacobs BC, , 2008. Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome. Lancet Neurol 7: 939950.[Crossref]
  5. Sahu R, Verma R, Jain A, Garg RK, Singh MK, Malhotra HS, Sharma PK, Parihar A, , 2014. Neurologic complications in dengue virus infection: a prospective cohort study. Neurology 83: 16011609.[Crossref]
  6. Davis LE, DeBiasi R, Goade DE, Haaland KY, Harrington JA, Harnar JB, Pergam SA, King MK, DeMasters BK, Tyler KL, , 2006. West Nile virus neuroinvasive disease. Ann Neurol 60: 286300.[Crossref]
  7. Lebrun G, Chadda K, Reboux A-H, Martinet O, Gaüzère B-A, , 2009. Guillain-Barré syndrome after chikungunya infection. Emerg Infect Dis 15: 495.[Crossref]
  8. Oehler E, Fournier E, Leparc-Goffart I, Larre P, Cubizolle S, Sookhareea C, Lastère S, Ghawche F, , 2015. Increase in cases of Guillain-Barré syndrome during a chikungunya outbreak, French Polynesia, 2014 to 2015. Euro Surveill 20: 30079.[Crossref]
  9. Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F, Baudouin L, Mallet H, Musso D, Ghawche F, , 2014. Zika virus infection complicated by Guillain-Barre syndrome–case report, French Polynesia, December 2013. Euro Surveill 19: 20720.[Crossref]
  10. Asbury AK, Cornblath DR, , 1990. Assessment of current diagnostic criteria for Guillain-Barré syndrome. Ann Neurol 27: S21S24.[Crossref]
  11. Hughes RA, Swan AV, van Doorn PA, , 2014 . Intravenous immunoglobulin for Guillain-Barré syndrome. Cochrane Database Syst Rev. Available at: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002063.pub6/full. Accessed October 5, 2015.
  12. Gérardin P, Couderc T, Bintner M, Tournebize P, Renouil M, Lémant J, Boisson V, Borgherini G, Staikowsky F, Schramm F, Lecuit M, Michault A, Encephalchik Study Group, 2016. Chikungunya virus-associated encephalitis: a cohort study on La Réunion Island, 2005–2009. Neurology 86: 94102.[Crossref]
  13. Torres JR, Córdova LG, Saravia V, Arvelaez J, Castro JS, , 2015. Nasal skin necrosis: an unexpected new finding in severe chikungunya fever. Clin Infect Dis 62: 7881.[Crossref]
  14. Rollé A, Schepers K, Cassadou S, Curlier E, Madeux B, Hermann-Storck C, Fabre I, Lamaury I, Tressières B, Thiery G, Hoen B, , 2016. Severe sepsis and septic shock associated with chikungunya virus infection, Guadeloupe, 2014. Emerg Infect Dis 22: 891894.[Crossref]
  15. Sivadon-Tardy V, Orlikowski D, Rozenberg F, Caudie C, Sharshar T, Lebon P, Annane D, Raphaël J-C, Porcher R, Gaillard J-L, , 2006. Guillain-Barré syndrome, greater Paris area. Emerg Infect Dis 12: 990.[Crossref]
  16. Webb AJ, Brain SA, Wood R, Rinaldi S, Turner MR, , 2015. Seasonal variation in Guillain-Barré syndrome: a systematic review, meta-analysis and Oxfordshire cohort study. J Neurol Neurosurg Psychiatry 86: 11961201.[Crossref]
  17. Soares CN, Cabral-Castro M, Oliveira C, Faria LC, Peralta JM, de Freitas MRG, Puccioni-Sohler M, , 2008. Oligosymptomatic dengue infection: a potential cause of Guillain Barré syndrome. Arq Neuropsiquiatr 66: 234237.[Crossref]
  18. Kanikannan MAK, Durga P, Venigalla NK, Kandadai RM, Jabeen SA, Borgohain R, , 2014. Simple bedside predictors of mechanical ventilation in patients with Guillain-Barré syndrome. J Crit Care 29: 219223.[Crossref]
  19. Rajabally YA, Uncini A, , 2012. Outcome and its predictors in Guillain–Barré syndrome. J Neurol Neurosurg Psychiatry 83: 711718.[Crossref]
  20. Teo TH, Her Z, Tan JJ, Lum FM, Lee WW, Chan YH, Ong RY, Kam YW, Leparc-Goffart I, Gallian P, Rénia L, de Lamballerie X, Ng LF, , 2015. Caribbean and La Réunion chikungunya virus isolates differ in their capacity to induce proinflammatory Th1 and NK cell responses and acute joint pathology. J Virol 89: 79557969.[Crossref]
  21. Wei Chiam C, Fun Chan Y, Chai Ong K, Thong Wong K, Sam IC, , 2015. Neurovirulence comparison of chikungunya virus isolates of the Asian and East/Central/South African genotypes from Malaysia. Gen Virol. 96: 32433254.[Crossref]
  22. Willison HJ, Jacobs BC, van Doorn PA, , 2016. Guillain-Barré syndrome. Lancet 388: 717727.[Crossref]
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  • Received : 16 Oct 2016
  • Accepted : 17 Sep 2016

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