1921
Volume 94, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

The study of the interactions among parasites within their hosts is crucial to the understanding of epidemiology of disease and for the design of effective control strategies. We have conducted an assessment of infections with , , , and in eastern Cameroon using a highly sensitive and specific quantitative polymerase chain reaction assay using archived dried whole blood spots. The resident population ( = 1,085) was parasitized with (76%), (39%), and (33%), but not with . Compared with single infections (40.1%), coinfection was more common (48.8%): 21.0% had (Ll/Mp/Pf), 2.7% had (Ll/Pf/Mp), 15.1% had (Mp/Pf/Ll), and 10.0% had (Ll/Mp/Pf). Interestingly, those with all three infections (Ll/Mp/Pf) had significantly higher microfilaria (mf) counts than either single Ll ( = 0.004) or double Ll/Mp ( = 0.024) infected individuals. Of those infected with , the mean estimated counts of mf varied based on location and were positively correlated with estimated intensities of mf. Finally, at a community level, heavy infections were concentrated in a few individuals whereby they were likely the major reservoir for infection.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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2016-06-01
2017-09-22
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Supplementary Data

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  • Received : 13 Oct 2015
  • Accepted : 23 Nov 2015

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