1921
Volume 95, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Kala-azar is a growing public health problem in Ethiopia. Benishangul-Gumuz regional state was previously not known to be endemic for the disease. In response to a case report from the region, we conducted a rapid assessment survey. A pretested questionnaire was used to capture sociodemographic and clinical histories pertinent to kala-azar. Study participants with complaints of fever and headache for 2 weeks or more were tested for kala-azar and malaria. All participants were screened with the leishmanin skin test and the direct agglutination test for exposure to , defined as a positive result with either or both tests. Of 275 participants, 20 were exposed giving an overall leishmaniasis seroprevalence rate of 7.3%. Among the 20 positive individuals, 19 were farmers and nine of them reported no travel history outside their district. It appears that kala-azar is emerging in Dangur and Guba districts of Benishangul-Gumuz regional state, probably in connection with human encroachment into one or several previously out-of-reach zoonotic foci. We recommend integrated epidemiological surveys for confirmation and early containment of disease transmission in the area.

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References

  1. Alvar J, Velez ID, Bern C, Herrero M, Desjeux P, Cano J, Jannin J, den Boer M, WHO Leishmaniasis Control Team, , 2012. Leishmaniasis worldwide and global estimates of its incidence. PLoS One 7: e35671.[Crossref] [Google Scholar]
  2. Tsegaw T, Gadisa E, Seid A, Abera A, Teshome A, Mulugeta A, Herrero M, Argaw D, Jorge A, Aseffa A, , 2013. Identification of environmental parameters and risk mapping of visceral leishmaniasis in Ethiopia by using geographical information systems and a statistical approach. Geospat Health 7: 299308.[Crossref] [Google Scholar]
  3. Federal Ministry of Health, 2013. Guidelines for Diagnosis, Treatment and Prevention of Leishmaniasis in Ethiopia, 2nd edition. Addis Ababa, Ethiopia: Ethiopian Federal Ministry of Health. [Google Scholar]
  4. Gadisa E, Tsegaw T, Abera A, Elnaiem DE, den Boer M, Aseffa A, Jorge A, , 2015. Eco-epidemiology of visceral leishmaniasis in Ethiopia. Parasit Vectors 8: 381.[Crossref] [Google Scholar]
  5. Boussery G, Boelaert M, van Peteghem J, Ejikon P, Henckaerts K, , 2001. Visceral leishmaniasis (kala-azar) outbreak in Somali refugees and Kenyan shepherds, Kenya. Emerg Infect Dis 7: 603604.[Crossref] [Google Scholar]
  6. Abubakar A, Ruiz-Postigo JA, Pita J, Lado M, Ben-Ismail R, Argaw D, Alvar J, , 2014. Visceral leishmaniasis outbreak in South Sudan 2009–2012: epidemiological assessment and impact of a multisectoral response. PLoS Negl Trop Dis 8: e2720.[Crossref] [Google Scholar]
  7. Raguenaud ME, Jansson A, Vanlerberghe V, Deborggraeve S, Dujardin JC, Orfanos G, Reid T, Boelaert M, , 2007. Epidemiology and clinical features of patients with visceral leishmaniasis treated by an MSF clinic in Bakool region, Somalia, 2004–2006. PLoS Negl Trop Dis 1: e85.[Crossref] [Google Scholar]
  8. Kirstein OD, Faiman R, Gebreselassie A, Hailu A, Gebre-Michael T, Warburg A, , 2013. Attraction of Ethiopian phlebotomine sand flies (Diptera: Psychodidae) to light and sugar-yeast mixtures (CO2). Parasit Vectors 6: 341.[Crossref] [Google Scholar]
  9. Abbasi I, Aramin S, Hailu A, Shiferaw W, Kassahun A, Belay S, Jaffe C, Warburg A, , 2013. Evaluation of PCR procedures for detecting and quantifying Leishmania donovani DNA in large numbers of dried human blood samples from a visceral leishmaniasis focus in northern Ethiopia. BMC Infect Dis 13: 153.[Crossref] [Google Scholar]
  10. Gebresilassie A, Yared S, Aklilu E, Kirstein OD, Moncaz A, Tekie H, Balkew M, Warburg A, Hailu A, Gebre-Michael T, , 2015. Host choice of Phlebotomus orientalis (Diptera: Psychodidae) in animal baited experiments: a field study in Tahtay Adiyabo district, northern Ethiopia. Parasit Vectors 8: 190.[Crossref] [Google Scholar]
  11. Alvar J, Bashaye S, Argaw D, Cruz I, Aparicio P, Kassa A, Orfanos G, Parreno F, Babaniyi O, Gudeta N, Canavate C, Bern C, , 2007. Kala-azar outbreak in Libo Kemkem, Ethiopia: epidemiologic and parasitologic assessment. Am J Trop Med Hyg 77: 275282. [Google Scholar]
  12. Herrero M, Orfanos G, Argaw D, Mulugeta A, Aparicio P, Parreno F, Bernal O, Rubens D, Pedraza J, Lima MA, Flevaud L, Palma PP, Bashaye S, Alvar J, Bern C, , 2009. Natural history of a visceral leishmaniasis outbreak in highland Ethiopia. Am J Trop Med Hyg 81: 373377. [Google Scholar]
  13. Lyons S, Veeken H, Long J, , 2003. Visceral leishmaniasis and HIV in Tigray, Ethiopia. Trop Med Int Health 8: 733739.[Crossref] [Google Scholar]
  14. Shanks L, Ritmeijer K, Piriou E, Siddiqui MR, Kliescikova J, Pearce N, Ariti C, Muluneh L, Masiga J, Abebe A, , 2015. Accounting for false positive HIV tests: is visceral leishmaniasis responsible? PLoS One 10: e0132422.[Crossref] [Google Scholar]
  15. Ali A, Ashford RW, , 1993. Visceral leishmaniasis in Ethiopia. I. Cross-sectional leishmanin skin test in an endemic locality. Ann Trop Med Parasitol 87: 157161.[Crossref] [Google Scholar]
  16. Hailu A, Gramiccia M, Kager PA, , 2009. Visceral leishmaniasis in Aba-Roba, south-western Ethiopia: prevalence and incidence of active and subclinical infections. Ann Trop Med Parasitol 103: 659670.[Crossref] [Google Scholar]
  17. Fuller GK, Lemma A, Haile T, Atwood CL, , 1976. Kala-azar in Ethiopia I: Leishmanin skin test in Setit Humera, a kala-azar endemic area in northwestern Ethiopia. Ann Trop Med Parasitol 70: 147163.[Crossref] [Google Scholar]
  18. Gebre-Michael T, Balkew M, Berhe N, Hailu A, Mekonnen Y, , 2010. Further studies on the phlebotomine sandflies of the kala-azar endemic lowlands of Humera-Metema (north-west Ethiopia) with observations on their natural blood meal sources. Parasit Vectors 3: 6.[Crossref] [Google Scholar]
  19. Gebre-Michael T, Lane RP, , 1996. The roles of Phlebotomus martini and P. celiae (Diptera: Phlebotominae) as vectors of visceral leishmaniasis in the Aba Roba focus, southern Ethiopia. Med Vet Entomol 10: 5362.[Crossref] [Google Scholar]
  20. Elnaiem DA, Hassan HK, Ward RD, , 1997. Phlebotomine sandflies in a focus of visceral leishmaniasis in a border area of eastern Sudan. Ann Trop Med Parasitol 91: 307318.[Crossref] [Google Scholar]
  21. Elnaiem DA, Hassan MM, Maingon R, Nureldin GH, Mekawi AM, Miles M, Ward RD, , 2001. The Egyptian mongoose, Herpestes ichneumon, is a possible reservoir host of visceral leishmaniasis in eastern Sudan. Parasitology 122: 531536.[Crossref] [Google Scholar]
  22. Elnaiem DE, Hassan HK, Osman OF, Maingon RD, Killick-Kendrick R, Ward RD, , 2011. A possible role for Phlebotomus (Anaphlebotomus) rodhaini (Parrot, 1930) in transmission of Leishmania donovani . Parasit Vectors 4: 238.[Crossref] [Google Scholar]
  23. Marlet MV, Sang DK, Ritmeijer K, Muga RO, Onsongo J, Davidson RN, , 2003. Emergence or re-emergence of visceral leishmaniasis in areas of Somalia, north-eastern Kenya, and south-eastern Ethiopia in 2000–01. Trans R Soc Trop Med Hyg 97: 515518.[Crossref] [Google Scholar]
  24. Anema A, Ritmeijer K, , 2005. Treating HIV/AIDS and leishmaniasis coinfection in Ethiopia. CMAJ 172: 14341435.[Crossref] [Google Scholar]
  25. Hailu A, Gebre-Michael T, Berhe N, Balkew M, Berhane Y, Mariam DH, Kloos H, , 2006. Leishmaniasis. , eds. Epidemiology and Ecology of Health and Disease in Ethiopia. Addis Ababa, Ethiopia: Shama Books. [Google Scholar]
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  • Received : 10 Oct 2015
  • Accepted : 19 Feb 2016

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