Volume 94, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Toxocariasis is an anthropozoonosis that occurs in all parts of the world. In particular, this disease can often be found in developing countries and in regions, where basic sanitation conditions are poor. However, industrialized countries have reported seroprevalence rates as high as 14.2% in humans. The definitive hosts of the disease are dogs and cats, whereas humans are a paratenic host. To determine the burden of toxocariasis in Brazil, we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to conduct a systematic review of the literature. Using keywords and applying the established criteria, we identified 160 publications and selected 22 articles for further analysis. The seroprevalence of toxocariasis in various regions of the country ranged from 4.2% to 65.4%. The highest prevalence was found in the northeast region, although the majority of the studies identified were from the southeast region. The findings suggest the importance of raising awareness among health professionals and public authorities about the fact that toxocariasis is a health problem.


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  1. Andrade LD, , 2000. Aspectos clinico-epidemiológicos da toxocaríase humana. Rev Patol Trop 29: 147159. [Google Scholar]
  2. Morimatsu Y, Akao N, Akiyoshi H, Kawazu T, Okabe Y, Aizawa H, , 2006. A familial case of visceral larva migrans after ingestion of raw chicken livers: appearance of specific antibody in bronchoalveolar lavage fluid of the patients. Am J Trop Med Hyg 75: 303306. [Google Scholar]
  3. Choi D, Lim JH, Choi D-C, Paik SW, Kim S-H, Huh S, , 2008. Toxocariasis and ingestion of raw cow liver in patients with eosinophilia. Korean J Parasitol 46: 139143.[Crossref] [Google Scholar]
  4. Rubinsky-Elefant G, Hirata CE, Yamamoto JH, Ferreira MU, , 2010. Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms. Ann Trop Med Parasitol 104: 323.[Crossref] [Google Scholar]
  5. Despommier D, , 2003. Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects. Clin Microbiol Rev 16: 265272.[Crossref] [Google Scholar]
  6. Maizels RM, , 2009. Exploring the immunology of parasitism—from surface antigens to the hygiene hypothesis. Parasitology 136 (Special Issue 12): 15491564.[Crossref] [Google Scholar]
  7. Lumeng CN, Saltiel AR, , 2011. Inflammatory links between obesity and metabolic disease. J Clin Invest 121: 21112117.[Crossref] [Google Scholar]
  8. Bergmann GG, Bergmann ML de A, Pinheiro E dos S, Moreira RB, Marques AC, Garlipp DC, Gaya DC, , 2009. Índice de massa corporal: tendência secular em crianças e adolescentes brasileiros. Rev Bras Cineantropometria Desempenho Hum 11: 280285. [Google Scholar]
  9. Terres NG, Pinheiro RT, Horta BL, Pinheiro KAT, Horta LL, , 2006. Prevalência e fatores associados ao sobrepeso e à obesidade em adolescentes. Rev Saude Publica 40: 627633.[Crossref] [Google Scholar]
  10. Fialho PMM, Corrêa CRS, , 2014. Toxocaríase, asma e índice de massa corporal em crianças e adolescentes em Campinas-SP, 1996 a 1998. Epidemiol E Serviços Saúde 23: 361368.[Crossref] [Google Scholar]
  11. Medronho RA, , 2009. Epidemiologia. São Paulo, Brazil: Atheneu. [Google Scholar]
  12. Smith H, Holland C, Taylor M, Magnaval J-F, Schantz P, Maizels R, , 2009. How common is human toxocariasis? Towards standardizing our knowledge. Trends Parasitol 25: 182188.[Crossref] [Google Scholar]
  13. Lescano SZ, Chieffi PP, Amato Neto V, Ikai DK, Ribeiro MCSA, , 2005. Anti-helmínticos na toxocaríase experimental: efeito na recuperação de larvas de Toxocara canis e na resposta humoral. J Bras Patol E Med Lab 41: 2124. [Google Scholar]
  14. Campos Júnior D, Elefant GR, de Melo e Silva EO, Gandolfi L, Jacob CMA, Tofeti A, Pratesi R, , 2003. Freqüência de soropositividade para antígenos de Toxocara canis em crianças de classes sociais diferentes. Rev Soc Bras Med Trop 36: 509513.[Crossref] [Google Scholar]
  15. Alonso JM, Bojanich MVI, Chamorro M, Gorodner JO, , 2000. Toxocara seroprevalence in children from a subtropical city in Argentina. Rev Inst Med Trop Sao Paulo 42: 235237.[Crossref] [Google Scholar]
  16. Shields JA, , 1984. Ocular toxocariasis. A review. Surv Ophthalmol 28: 361381.[Crossref] [Google Scholar]
  17. Ajayi O, Duhlinska D, Agwale S, Njoku M, , 2000. Frequency of human toxocariasis in Jos, Plateau State, Nigeria. Mem Inst Oswaldo Cruz 95: 147149.[Crossref] [Google Scholar]
  18. Gueglio B, de Gentile L, Nguyen JM, Achard J, Chabasse D, Marjolet M, , 1994. Epidemiologic approach to human toxocariasis in western France. Parasitol Res 80: 531536.[Crossref] [Google Scholar]
  19. Lynch N, Hagel I, Vargas V, Rotundo A, Varela M, Di Prisco M, Hodgen AN, , 1993. Comparable seropositivity for ascariasis and toxocariasis in tropical slum children. Parasitol Res 79: 547550.[Crossref] [Google Scholar]
  20. Baboolal S, Rawlins SC, , 2002. Seroprevalence of toxocariasis in schoolchildren in Trinidad. Trans R Soc Trop Med Hyg 96: 139143.[Crossref] [Google Scholar]
  21. Lee RM, Moore LB, Bottazzi ME, Hotez PJ, , 2014. Toxocariasis in North America: a systematic review. PLoS Negl Trop Dis 8: e3116.[Crossref] [Google Scholar]
  22. Hotez PJ, , 2008. Neglected infections of poverty in the United States of America. PLoS Negl Trop Dis 2: e256.[Crossref] [Google Scholar]
  23. Parise ME, Hotez PJ, Slutsker L, , 2014. Neglected parasitic infections in the United States: needs and opportunities. Am J Trop Med Hyg 90: 783785.[Crossref] [Google Scholar]
  24. Marchioro AA, Colli CM, Ferreira ÉC, Viol BM, Araújo SM, Falavigna-Guilherme AL, , 2014. Risk factors associated with toxoplasmosis and toxocariasis in populations of children from nine cities in southern Brazil. J Helminthol 89: 428432.[Crossref] [Google Scholar]
  25. Cassenote AJF, de Abreu Lima AR, Pinto Neto JM, Rubinsky-Elefant G, , 2014. Seroprevalence and modifiable risk factors for Toxocara spp. in Brazilian schoolchildren. PLoS Negl Trop Dis 8: e2830.[Crossref] [Google Scholar]
  26. Negri EC, Santarém VA, Rubinsky-Elefant G, Giuffrida R, , 2013. Anti-Toxocara spp. antibodies in an adult healthy population: serosurvey and risk factors in Southeast Brazil. Asian Pac J Trop Biomed 3: 211216.[Crossref] [Google Scholar]
  27. Guilherme EV, Marchioro AA, Araujo SM, Falavigna DL, Adami C, Falavigna-Guilherme G, Rubinsky-Elefant G, Falavigna-Guilherme AL, , 2013. Toxocariasis in children attending a Public Health Service Pneumology Unit in Paraná State, Brazil. Rev Inst Med Trop Sao Paulo 55: 189192.[Crossref] [Google Scholar]
  28. Schoenardie ER, Scaini CJ, Brod CS, Pepe MS, Villela MM, McBride AJA, Borsuk S, Berne MEA, , 2013. Seroprevalence of Toxocara infection in children from southern Brazil. J Parasitol 99: 537539.[Crossref] [Google Scholar]
  29. Prestes-Carneiro LE, Rubinsky-Elefant G, Ferreira AW, Araujo PR, Troiani C, Zago SC, Kaiahara M, Sasso L, Iha A, Vaz A, , 2013. Seroprevalence of toxoplasmosis, toxocariasis and cysticercosis in a rural settlement, São Paulo State, Brazil. Pathog Glob Health 107: 8895.[Crossref] [Google Scholar]
  30. Manini MP, Marchioro AA, Colli CM, Nishi L, Falavigna-Guilherme AL, , 2012. Association between contamination of public squares and seropositivity for Toxocara spp. in children. Vet Parasitol 188: 4852.[Crossref] [Google Scholar]
  31. Mattia S, Colli CM, Adami CM, Guilherme GF, Nishi L, Rubinsky-Elefant G, Marchioro AA, Gomes ML, Falavigna-Guilherme AL, , 2012. Seroprevalence of Toxocara infection in children and environmental contamination of urban areas in Paraná State, Brazil. J Helminthol 86: 440445.[Crossref] [Google Scholar]
  32. Fragoso RP, Monteiro MBM, Lemos EM, Pereira FEL, , 2011. Anti-Toxocara antibodies detected in children attending elementary school in Vitoria, State of Espírito Santo, Brazil: prevalence and associated factors. Rev Soc Bras Med Trop 44: 461466.[Crossref] [Google Scholar]
  33. Marchioro AA, Colli CM, Mattia S, Paludo ML, de Melo GC, Adami CM, Pelloso SM, Guilherme ALF, , 2011. Avaliação eosinofílica e soropositividade para anticorpos IgG anti-Toxocara em crianças atendidas pelo Sistema Único de Saúde. Rev Paul Pediatr 29: 8084.[Crossref] [Google Scholar]
  34. Santarém VA, Leli FNC, Rubinsky-Elefant G, Giuffrida R, , 2011. Protective and risk factors for toxocariasis in children from two different social classes of Brazil. Rev Inst Med Trop Sao Paulo 53: 6672.[Crossref] [Google Scholar]
  35. Correa CRS, Bismarck CM, , 2010. Toxocariasis: incidence, prevalence and the time serum remains positive in school children from Campinas, SP, Brazil. J Trop Pedriatrics 56: 215216.[Crossref] [Google Scholar]
  36. Colli CM, Rubinsky-Elefant G, Paludo ML, Falavigna DLM, Guilherme EV, Mattia S, Araujo SM, Ferreira É, Previdelli ITS, Falavigna-Guilherme AL, , 2010. Serological, clinical and epidemiological evaluation of toxocariasis in urban areas of south Brazil. Rev Inst Med Trop Sao Paulo 52: 6974.[Crossref] [Google Scholar]
  37. Prestes-Carneiro LE, Souza DHP, Moreno GC, Troiani C, Santarém V, Zago SCS, Miguel NA, Freitas SBZ, Faria R, Martini L, Rubinsky-Elefant G, Iha A, Vaz AJ, , 2009. Toxocariasis/cysticercosis seroprevalence in a long-term rural settlement, São Paulo, Brazil. Parasitology 136: 681689.[Crossref] [Google Scholar]
  38. Prestes-Carneiro LE, Santarém V, Zago SCS, Miguel NA, Zambelli S de F, Villas R, Vaz AJ, Rubinsky-Elefant G, , 2008. Sero-epidemiology of toxocariasis in a rural settlement in São Paulo state, Brazil. Ann Trop Med Parasitol 102: 347356.[Crossref] [Google Scholar]
  39. Mendonça LR, Figueiredo CA, Esquivel R, Fiaccone RL, Pontes-de-Carvalho L, Cooper P, Barreto ML, Alcantara-Neves NM, , 2013. Seroprevalence and risk factors for Toxocara infection in children from an urban large setting in northeast Brazil. Acta Trop 128: 9095.[Crossref] [Google Scholar]
  40. Mendonça LR, Veiga RV, Dattoli VCC, Figueiredo CA, Fiaccone R, Santos J, Cruz ÁA, Rodrigues LC, Cooper PJ, Pontes-de-Carvalho LC, Barreto ML, Alcantara-Neves NM, , 2012. Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. PLoS Negl Trop Dis 6: e1886.[Crossref] [Google Scholar]
  41. Souza RF, Dattoli VCC, Mendonça LR, Jesus JR, Baqueiro T, Santana C de C, Santos NM, Barrouin-Melo SM, Alcantara-Neves NM, , 2011. Prevalência e fatores de risco da infecção humana por Toxocara canis em Salvador, Estado da Bahia. Rev Soc Bras Med Trop 44: 516519.[Crossref] [Google Scholar]
  42. Dattoli VCC, Freire SM, Mendonça LR, Santos PC, Meyer R, Alcantara-Neves NM, , 2011. Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre. Trop Med Int Health 16: 514517.[Crossref] [Google Scholar]
  43. Oliart-Guzmán H, Delfino BM, Martins AC, Mantovani SAS, Braña AM, Pereira TM, Branco FLCC, Ramalho AA, Campos RG, Fontoura PS, de Araujo TS, de Oliveira CSM, Muniz PT, Rubinsky-Elefant G, Codeço CT, da Silva-Nunes M, , 2014. Epidemiology and control of child toxocariasis in the western Brazilian Amazon—a population-based study. Am J Trop Med Hyg 90: 670681.[Crossref] [Google Scholar]
  44. Rubinsky-Elefant G, da Silva-Nunes M, Malafronte RS, Muniz PT, Ferreira MU, , 2008. Human toxocariasis in rural Brazilian Amazonia: seroprevalence, risk factors, and spatial distribution. Am J Trop Med Hyg 79: 9398. [Google Scholar]
  45. Núñez CR, Martínez GDM, Arteaga SY, Macotela MP, Montes PB, Durán NR, , 2013. Prevalence and risk factors associated with Toxocara canis infection in children. Scientific World J 2013: 572089. [Google Scholar]
  46. Kim Y-H, Huh S, Chung Y-B, , 2008. Seroprevalence of toxocariasis among healthy people with eosinophilia. Korean J Parasitol 46: 2932.[Crossref] [Google Scholar]
  47. Roldán WH, Espinoza YA, Atúncar A, Ortega E, Martinez A, Saravia M, , 2008. Frequency of eosinophilia and risk factors and their association with Toxocara infection in schoolchildren during a health survey in the north of Lima, Peru. Rev Inst Med Trop Sao Paulo 50: 273278.[Crossref] [Google Scholar]
  48. Paludo ML, Falavigna DLM, Elefant GR, Gomes ML, Baggio MLM, Amadei LB, Falavigna-Guilherme AL, , 2007. Frequency of Toxocara infection in children attended by the health public service of Maringá, south Brazil. Rev Inst Med Trop Sao Paulo 49: 343348.[Crossref] [Google Scholar]
  49. Figueiredo SDP, Taddei JAAC, Menezes JJC, Novo NF, Silva EOM, Cristóvão HLG, Cury MCFS, , 2005. Estudo clínico-epidemiológico da toxocaríase em população infantil. J Pediatr (Rio J) 81: 126132.[Crossref] [Google Scholar]
  50. Jacob CMA, Pastorino AC, Peres BA, Mello EO, Okay Y, Oselka GW, , 1994. Clinical and laboratorial features of visceral toxocariasis in infancy. Rev Inst Med Trop Sao Paulo 36: 1926.[Crossref] [Google Scholar]
  51. Woodhall DM, Eberhard ML, Parise ME, , 2014. Neglected parasitic infections in the United States: toxocariasis. Am J Trop Med Hyg 90: 810813.[Crossref] [Google Scholar]
  52. Won KY, Kruszon-Moran D, Schantz PM, Jones JL, , 2008. National seroprevalence and risk factors for zoonotic Toxocara spp. infection. Am J Trop Med Hyg 79: 552557. [Google Scholar]

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  • Received : 08 Oct 2015
  • Accepted : 16 Dec 2015
  • Published online : 01 Jun 2016

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