1921
Volume 95, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Infections with helminths and spp. overlap in their geographical distribution. It has been postulated that helminth infections may influence malarial transmission by altering gametocytogenesis. This cross-sectional study assessed the effect of helminth infections on gametocyte carriage and on humoral immune responses to sexual stage antigens in Gabon. and filarial infections as well as asexual forms and gametocyte carriage were determined. The antibody responses measured were to sexual (Pfs230, Pfs48/45) and asexual antigens (AMA1, MSP1, and GLURP). A total of 287 subjects were included. The prevalence of microscopically detectable asexual parasites was higher in –infected subjects in comparison to their uninfected counterparts (47% versus 26%, = 0.003), but this was not different when filarial infections were considered. gametocyte carriage was similar between - or filaria-infected and uninfected subjects. We observed a significant decrease of Pfs48/45 immunoglobulin G titer in –infected subjects ( = 0.037), whereas no difference was seen for Pfs230 antibody titer, nor for antibodies to AMA1, MSP1, or GLURP. Our findings suggest an effect of on antibody responses to some gametocyte antigens that may have consequences for transmission-blocking immunity.

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  • Received : 27 Sep 2015
  • Accepted : 28 Dec 2015

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