1921
Volume 94, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Chikungunya virus (CHIKV) is an arthropod-borne virus, which is known to cause severe disease only in humans. To investigate its potential zoonotic host range and evaluate reservoir competence among these hosts, experimental infections were performed on individuals from nine avian and 12 mammalian species representing both domestic and wild animals common to North America. Hamsters and inbred mice have previously been shown to develop viremia after inoculation with CHIKV and were used as positive controls for infection. Aside from big brown bats (), none of the mammals or birds developed detectable viremia or overt clinical disease. However, most mammals and a smaller proportion of birds developed neutralizing antibody responses to CHIKV. On the basis of these results, it seems unlikely that CHIKV poses a significant health threat to most domestic animals or wildlife and that the species examined do not likely contribute to natural transmission cycles. Additional studies should further evaluate bats and wild rodents as potential reservoir hosts for CHIKV transmission during human epidemics.

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2016-03-02
2017-09-25
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References

  1. Weaver SC, Lecuit M, , 2015. Chikungunya virus and the global spread of mosquito-borne disease. N Engl J Med 372: 12311239.[Crossref]
  2. Yergolkar PN, Tandale BV, Arankalle VA, Sathe PS, Sudeep AB, Gandhe SS, Gokhle MD, Jacob GP, Hundekar SL, Mishra AC, , 2006. Chikungunya outbreaks caused by African genotype, India. Emerg Infect Dis 12: 15801583.[Crossref]
  3. Higgs S, , 2006. The 2005–2006 chikungunya epidemic in the Indian Ocean. Vector Borne Zoonotic Dis 6: 115116.[Crossref]
  4. Charrel RN, de Lamballerie X, Raoult D, , 2007. Chikungunya outbreaks—the globalization of vectorborne diseases. N Engl J Med 356: 769771.[Crossref]
  5. Tsetsarkin KA, Vanlandingham DL, McGee GE, Higgs S, , 2007. A single mutation in chikungunya virus affects vector specificity and epidemic potential. PLoS Pathog 3: e201.[Crossref]
  6. Vega-Rúa A, Zouache K, Girod R, Failloux AB, Lourenco-de-Oliviera R, , 2014. High vector competence of Aedes aegypti and Aedes albopictus from ten American countries as a critical factor in the spread of chikungunya virus. J Virol 88: 62946306.[Crossref]
  7. Tesh RB, , 1982. Arthritides caused by mosquito-borne viruses. Annu Rev Med 33: 3140.[Crossref]
  8. Turell MJ, Beaman JR, Tammariello RF, , 1992. Susceptibility of selected strains of Aedes aegypti and Aedes albopictus (Dipteral: Culicidae) to chikungunya virus. J Med Entomol 29: 4953.[Crossref]
  9. Diallo M, Thonnon J, Traore-Lamizana M, Fontenille D, , 1999. Vectors of chikungunya virus in Senegal: current data and transmission cycles. Am J Trop Med Hyg 60: 281286.
  10. MacKenzie JS, Jeggo M, , 2013. Reservoirs and vectors of emerging viruses. Curr Opin Virol 3: 170179.[Crossref]
  11. Kuehn BM, , 2014. Chikungunya virus transmission found in the United States: US health authorities brace for wider spread. JAMA 312: 776777.[Crossref]
  12. Morrison TE, , 2014. Reemergence of chikungunya virus. J Virol 88: 1164411647.[Crossref]
  13. Chevillon C, Briant L, Renaud F, Devauz C, , 2008. The chikungunya threat: an ecological and evolutionary perspective. Trends Microbiol 16: 8088.[Crossref]
  14. Diallo D, Sall AA, Buenemann M, Chen R, Faye R, Diagne CT, Faye O, Ba Y, Dia I, Watts D, Weaver SC, Hanley KA, Diallo M, , 2012. Landscape ecology of sylvatic chikungunya virus and mosquito vectors in southeastern Senegal. PLoS Negl Trop Dis 6: e1649.[Crossref]
  15. Sam I, Chua CL, Rovie-Ryan JJ, Fu JYL, Tong C, Sitam FT, Chan YF, , 2015. Chikungunya virus in macaques, Malaysia. Emerg Infect Dis 21: 16831685.[Crossref]
  16. Bosco-Lauth AM, Han S, Hartwig A, Bowen RA, , 2015. Development of a hamster model for chikungunya virus infection and pathogenesis. PLoS One 10: e0130150.[Crossref]
  17. Ziegler SA, Lu L, da Rosa AP, Xiao SY, Tesh RB, , 2008. An animal model for studying the pathogenesis of chikungunya virus infection. Am J Trop Med Hyg 79: 133139.
  18. Teo TH, Lum FM, Lee WW, Ng LF, , 2012. Mouse models for chikungunya virus: deciphering immune mechanisms responsible for disease and pathology. Immunol Res 53: 136147.[Crossref]
  19. Inoue S, Morita K, Matias RR, Tuplano JV, Resuello RR, Candelario JR, Cruz DJ, Mapua CA, Hasebe F, Igarashi A, Natividad FF, , 2003. Distribution of three arbovirus antibodies among monkeys (Macaca fascicularis) in the Philippines. J Med Primatol 32: 8994.[Crossref]
  20. Vourc'h G, Halos L, Desvars A, Boué F, Pascal M, Lecollinet S, Zientara S, Duval T, Nzonza A, Brémont M, , 2014. Chikungunya antibodies detected in non-human primates and rats in three Indian Ocean islands after the 2006 ChikV outbreak. Vet Res 45: 5257.[Crossref]
  21. Rezza G, Nicoletti L, Angelini R, Romi R, Finarelli AC, Panning M, Cordioli P, Fortuna C, Boros S, Magurano F, Silvi G, Angelini P, Dottori M, Ciufolini MG, Majori GC, Cassone A, CHIKV Study Group, , 2007. Infection with chikungunya virus in Italy: an outbreak in a temperate region. Lancet 370: 18401846.[Crossref]
  22. Thiberville SD, Boisson V, Gaudart J, Simon F, Flahault A, de Lamballerie X, , 2013. Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, South-West Indian Ocean. PLoS Negl Trop Dis 7: e2004.[Crossref]
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  • Received : 23 Sep 2015
  • Accepted : 27 Oct 2015

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