1921
Volume 94, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Recent evidence suggests an association between human immunodeficiency virus (HIV) and female genital schistosomiasis (FGS) in sub-Saharan Africa, especially in Mozambique, South Africa, Tanzania, and Zimbabwe. Women with FGS have increased numbers of HIV target cells and cell receptors in genital and blood compartments, potentially increasing the risk of HIV transmission per sexual exposure, and the association may explain the high female:male ratio of HIV prevalence unique to sub-Saharan Africa. We investigate this association in Mozambique by linking two georeferenced, high-quality secondary data sources on HIV prevalence and : the AIDS Indicator Survey, and the Global Neglected Tropical Diseases (GNTD) open-source database, respectively. We construct a schistosomiasis exposure covariate indicating women reporting “unimproved” daily drinking water sources and living no more than 2–5 km from high-endemic global positioning system (GPS) coordinates in the GNTD. In logistic regression analyses predicting HIV-positive status, we show that exposure increases the odds of HIV-positive status by three times, controlling for demographic and sexual risk factors.

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2016-05-04
2017-11-19
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References

  1. Efraim L, Peck RN, Kalluvya SE, Kabangila R, Mazigo HD, Mpondo B, Bang H, Todd J, Fitzgerald DW, Downs JA, , 2013. Schistosomiasis and impaired response to antiretroviral therapy among HIV-infected patients in Tanzania. J Acquir Immune Defic Syndr 62: E153E156.[Crossref]
  2. Brown M, Mawa PA, Kaleebu P, Elliott AM, , 2006. Helminths and HIV infection: epidemiological observations on immunological hypotheses. Parasite Immunol 28: 613623.[Crossref]
  3. Walson JL, Otieno PA, Mbuchi M, Richardson BA, Lohman-Payne B, Macharia SW, Overbaugh J, Berkley J, Sanders EJ, Chung MH, John-Stewart GC, , 2008. Albendazole treatment of HIV-1 and helminth co-infection: a randomized, double-blind, placebo-controlled trial. AIDS 22: 16011609.[Crossref]
  4. Hughes JP, Baeten JM, Lingappa JR, Magaret AS, Wald A, de Bruyn G, Kiarie J, Inambao M, Kilembe W, Farquhar C, Celum C, , 2012. Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples. J Infect Dis 205: 358365.[Crossref]
  5. Mbabazi PS, Andan O, Fitzgerald DW, Chitsulo L, Engels D, Downs JA, , 2011. Examining the relationship between urogenital schistosomiasis and HIV infection. PLoS Negl Trop Dis 5: e1396.[Crossref]
  6. Barongo LR, Borgdorff MW, Mosha FF, Nicoll A, Grosskurth H, Senkoro KP, Newell JN, Changalucha J, Klokke AH, Killewo JZ, Velema JP, Hayes RJ, Dunn DT, Muller LAS, Rugemalila JB, , 1992. The epidemiology of HIV-1 infection in urban areas, roadside settlements and rural villages in Mwanza Region, Tanzania. AIDS 6: 15211528.[Crossref]
  7. World Health Organization, 2014. Schistosomiasis: A Major Public Health Problem. Available at: http://www.who.int/schistosomiasis/en/. Accessed July 10, 2014.
  8. World Health Organization, 2014. Schistosomiasis Fact Sheet. Available at: http://www.who.int/mediacentre/factsheets/fs115/en/. Accessed July 10, 2014.
  9. Bustinduy A, King C, Scott J, Appleton S, Sousa-Figueiredo JC, Betson M, Stothard JR, , 2014. HIV and schistosomiasis co-infection in African children. Lancet Infect Dis 14: 640649.[Crossref]
  10. Kleppa E, Ramsuran V, Zulu S, Karlsen GH, Bere A, Passmore JAS, Ndhlovu P, Lillebo K, Holmen SD, Onsrud M, Gundersen SG, Taylor M, Kjetland EF, Ndung'u T, , 2014. Effect of female genital schistosomiasis and anti-schistosomal treatment on monocytes, CD4+ T-cells and CCR5 expression in the female genital tract. PLoS One 9: e98953.[Crossref]
  11. Kjetland EF, Ndhlovu PD, Gomo E, Mduluza T, Midzi N, Gwanzura L, Mason PR, Sandvik L, Friis H, Gundersen SG, , 2006. Association between genital schistosomiasis and HIV in rural Zimbabwean women. AIDS 20: 593600.[Crossref]
  12. Kjetland EF, Hegertun IEA, Baay MFD, Onsrud M, Ndhlovu PD, Taylor M, , 2014. Genital schistosomiasis and its unacknowledged role on HIV transmission in the STD intervention studies. Int J STD AIDS 25: 705715.[Crossref]
  13. Downs JA, Mguta C, Kaatano GM, Mitchell KB, Bang H, Simplice H, Kalluvya SE, Changalucha JM, Johnson WD, Fitzgerald DW, , 2011. Urogenital schistosomiasis in women of reproductive age in Tanzania's Lake Victoria region. Am J Trop Med Hyg 84: 364369.[Crossref]
  14. Downs JA, van Dam GJ, Changalucha JM, Corstjens PLAM, Peck RN, de Dood CJ, Bang H, Andreasen A, Kalluvya SE, van Lieshout L, Johnson WD, Fitzgerald DW, , 2012. Association of schistosomiasis and HIV infection in Tanzania. Am J Trop Med Hyg 87: 868873.[Crossref]
  15. Hotez PJ, Fenwick A, Kjetland EF, , 2009. Africa's 32 cents solution for HIV/AIDS. PLoS Negl Trop Dis 3: e430.[Crossref]
  16. McNeil DG, Jr, 2014. A Simple Theory, and A Proposal, on H.I.V. in Africa. New York, NY: The New York Times.
  17. MEASURE DHS, 2010. The 2009 National Survey on Prevalence, Behavioral Risks and Information about HIV and AIDS in Mozambique (INSIDA). AIDS Indicator Survey. Calverton, MD: ICF Macro.
  18. Hurlimann E, Schur N, Boutsika K, Stensgaard AS, de Himpsl ML, Ziegelbauer K, Laizer N, Camenzind L, Di Pasquale A, Ekpo UF, Simoonga C, Mushinge G, Saarnak CFL, Utzinger J, Kristensen TK, Vounatsou P, , 2011. Toward an open-access global database for mapping, control, and surveillance of neglected tropical diseases. PLoS Negl Trop Dis 5: e1404.[Crossref]
  19. Picard R, , 2010. GEONEAR: Stata Module to Find Nearest Neighbors Using Geodetic Distances. Chestnut Hill, MA: Boston College Department of Economics.
  20. WHO/UNICEF Joint Monitoring Programme (JMP) for Water Supply and Sanitation, 2015. Improved and Unimproved Water Sources and Sanitation Facilities. Available at: http://www.wssinfo.org/definitions-methods/watsan-categories/. Accessed November 3, 2015.
  21. Augusto G, Nala R, Casmo V, Sabonete A, Mapaco L, Monteiro J, , 2009. Geographic distribution and prevalence of schistosomiasis and soil-transmitted helminths among schoolchildren in Mozambique. Am J Trop Med Hyg 81: 799803.[Crossref]
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  • Received : 08 Sep 2015
  • Accepted : 05 Feb 2016

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