Volume 94, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Refractory and relapsing crytocococcosis in acquired immune deficiency syndrome (AIDS) patients have a poor prognosis. The risk factors for this complicated infection course were evaluated by comparing refractory and/or relapsing cryptococcosis in human immunodeficiency virus–coinfected patients (cohort 1) with another group of AIDS patients who adequately responded to antifungals (cohort 2). Except for one isolate of from a cohort 2 case, all other isolates were identified as var. , sex type α, genotype VNI, including reisolated from the relapse or in the refractory state. No differences were observed with respect to capsule size and in the melanin and phospholipase production. The cohort 1 patients presented higher prevalence of cryptococcemia, cerebral dissemination, chronic liver disease, and leucopenia, and have increased death rate. Apparently, the refractory and/or relapsing cryptococcosis in the AIDS patients were more related to the host and the extent of the infection than to the fungal characteristics.


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Supplementary PDF

  • Received : 13 Aug 2015
  • Accepted : 16 Jan 2016
  • Published online : 04 May 2016

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