1921
Volume 94, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

This study evaluated the prevalence of infection and human T-cell lymphotropic virus type 1 (HTLV-1) infection in the population. In addition, this study investigated the relationship between infection or HTLV-1 infection and a patient's risk of developing related cancers. This is a retrospective cohort study of 5,209 patients. The prevalence of infection was 5.2% among all patients. The prevalence among men (6.3%) was significantly higher than among women (3.6%, < 0.001). The prevalence of HTLV-1 infection among this population was 13.6% and the prevalence among women (15.5%) was significantly higher than that of men (12.3%, < 0.001). HTLV-1 seroprevalence was higher in patients with liver cancer ( = 0.003, odds ratio [OR]: 1.91, 95% confidence interval [CI]: 1.24, 2.95) and in those with lymphoma other than adult T-cell leukemia/lymphoma (ATLL) ( = 0.005, adjusted OR: 2.76, 95% CI: 1.36, 5.62) if compared with patients without any neoplasm. The prevalence of both and HTLV-1 in the Okinawan population has been steadily decreasing over the past 24 years. HTLV-1 infection significantly increases the odds of developing liver cancer and lymphomas other than ATLL.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.15-0556
2016-02-03
2017-11-18
Loading full text...

Full text loading...

/deliver/fulltext/14761645/94/2/365.html?itemId=/content/journals/10.4269/ajtmh.15-0556&mimeType=html&fmt=ahah

References

  1. Asato R, Nakasone T, Yoshida C, Arakakai T, Ikeshiro T, Murakami H, , 1992. Current status of Strongyloides infection in Okinawa, Japan. Jpn J Trop Med Hgy 20: 169173.[Crossref]
  2. Toma H, Shimabukuro I, Kobayashi J, Tasaki T, Takara M, Sato Y, , 2000. Community control studies on Strongyloides infection in a model island of Okinawa, Japan. Southeast Asian J Trop Med Public Health 31: 383387.
  3. Zaha O, Hirata T, Kinjo F, Saito A, , 2000. Strongyloidiasis—progress in diagnosis and treatment. Intern Med 39: 695700.[Crossref]
  4. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC, , 1980. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77: 74157419.[Crossref]
  5. Yoshida M, Miyoshi I, Hinuma Y, , 1982. Isolation and characterization of retrovirus from cell lines of human T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 79: 20312035.[Crossref]
  6. Proietti FA, Carnerio-Proietti AB, Catalan-Soares BC, Murphy EL, , 2005. Global epidemiology of HTLV-1 infection and associated diseases. Oncogene 24: 60586068.[Crossref]
  7. Tajima K, , 1988. The third nation-wide study on adult T-cell leukemia/lymphoma (ATL) in Japan: characteristic patterns of HLA antigen and HTLV-1 infection in ATL patients and their relatives. Int J Cancer 41: 505512.[Crossref]
  8. Wilks R, Hanchard B, Morgan O, Williams E, Cranston B, Smith ML, Rodgers-Johnson P, Manns A, , 1996. Patterns of HTLV-1 infection among family members of patients with adult T-cell leukemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis. Int J Cancer 65: 272273.[Crossref]
  9. Khurana S, Dubey ML, Malla N, , 2005. Association of parasitic infections and cancers. Indian J Med Microbiol 23: 7479.[Crossref]
  10. Arisawa K, Sobue T, Yoshimi I, Soda M, Shirahama S, Doi H, Katamine S, Saito H, Urata M, , 2003. Human T-lymphotropic virus type-1 infection, survival and cancer risk in southwestern Japan: a prospective cohort study. Cancer Causes Control 14: 889896.[Crossref]
  11. Hirata T, Nakamoto M, Nakamura M, Kinjo N, Hokama A, Kinjo F, Fujita J, , 2007. Low prevalence of human T cell lymphotropic virus type 1 infection in patients with gastric cancer. J Gastroenterol Hepatol 22: 22382241.[Crossref]
  12. Arisawa K, Soda M, Akahoshi M, Fujiwara S, Uemura H, Hiyoshi M, Takeda H, Kashino W, Suyama A, , 2006. Human T-cell lymphotropic virus type-1 infection and risk of cancer: 15.4 year longitudinal study among atomic bomb survivors in Nagasaki, Japan. Cancer Sci 97: 535539.[Crossref]
  13. Arakaki T, Iwanaga M, Kinjo F, Saito A, Asato R, Ikeshiro T, , 1990. Efficacy of agar-plate culture in detection of Strongyloides stercoralis infection. J Parasitol 76: 425428.[Crossref]
  14. Fujino R, Kawato K, Ikeda M, Miyakoshi H, Mizukoshi M, Imai J, , 1991. Improvement of gelatin particle agglutination test for detection of anti-HTLV-1 antibody. Jpn J Cancer Res 82: 367370.[Crossref]
  15. Aoyama H, Hirata T, Sakugawa H, Watanabe T, Miyagi S, Maeshiro T, Chinen T, Kawane M, Zaha O, Nakayoshi T, Kinjo F, Fujita J, , 2007. An inverse relationship between autoimmune liver diseases and Strongyloides stercoralis infection. Am J Trop Med Hyg 76: 972976.
  16. Yoshikawa M, Ouji Y, Nakamura-Uchiyama F, Nawa Y, , 2014. Analysis of strongyloidiasis cases reported in Japan in the recent period, 2000–2013 [in Japanese]. Clin Parasitol 25: 2026.
  17. Ogawa S, Boostrom E, , 2009. Okinawa's Post-War Health Recovery and Development: Relevance for International Health. Kanagawa, Japan: Seizansha.
  18. Sataka M, Yamaguchi K, Tadokoro K, , 2012. Current prevalence of HTLV-1 in Japan as determined by screening of blood donors. J Med Virol 84: 327335.[Crossref]
  19. Hirata T, Uchima N, Kishimoto K, Zaha O, Kinjo N, Hokama A, Sakugawa H, Kinjo F, Fujita J, , 2006. Impairment of host immune response against Strongyloides stercoralis by human T cell lymphotropic virus type 1 infection. Am J Trop Med Hyg 74: 246249.
  20. Inaba S, Sato H, Okochi K, Fukuda K, Takakura F, Tokunaga K, , 1989. Prevention of transmission of human T-lymphotropic virus type 1 (HTLV-1) through transfusion, by donor screening with antibody to the virus. One-year experience. Transfusion 29: 711.[Crossref]
  21. Ando Y, Saito K, Nakano S, Kakimoto K, Furuki K, Tanigawa T, Hashimoto H, Moriyama I, Ichijo M, Toyama T, , 1989. Bottle-feeding can prevent transmission of HTLV-1 from mothers to their babies. J Infect 19: 2529.[Crossref]
  22. Kinoshita K, Hino S, Amagasaki T, Ikeda S, Yamada Y, Suzuyama J, Momita S, Toriya K, Kamihira S, Ichimaru M, , 1984. Demonstration of adult T-cell leukemia virus antigen in milk from three sero-positive mothers. Gan 75: 103105.
  23. Nakano S, Ando Y, Ichijo M, Moriyama I, Saito S, Sugamura K, Hinuma Y, , 1984. Search for possible routes of vertical and horizontal transmission of adult T-cell leukemia virus. Gan 75: 10441045.
  24. The Japanese Ministry of Health, Labour and Welfare study group, 2011. HTLV-1 Carrier, Guide of the Instruction. Japan. [In Japanese].
  25. Nakada K, Kohakura M, Komoda H, Hinuma K, , 1984. High incidence of HTLV antibody in carriers of Strongyloides stercoralis . Lancet 1: 633.[Crossref]
  26. Hayashi J, Kishihara Y, Yoshimura E, Furusyo N, Yamaji K, Kawakami K, Murakami H, Kashiwagi S, , 1997. Correlation between human T cell lymphotropic virus type-1 and Strongyloides stercoralis infections and serum immunoglobulin E responses in residents of Okinawa, Japan. Am J Trop Med Hyg 56: 7175.
  27. Carvalho EM, Da Fronseca Porto A, , 2004. Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis . Parasite Immunol 26: 487497.[Crossref]
  28. Gotuzzo E, Terashima A, Alvarez H, Tello R, Infante R, Watts DM, Freedman DO, , 1999. Strongyloides stercoralis hyperinfection associated with human T cell lymphotropic virus type-1 infection in Peru. Am J Trop Med Hyg 60: 146149.
  29. Montes M, Sanchez C, Verdonck K, Lake JE, Gonzalez E, Lopez G, Terashima A, Nolan T, Lewis DE, Gotuzzo E, White AC, Jr, 2009. Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen. PLoS Negl Trop Dis 3: e456.[Crossref]
  30. Stuver SO, Tachibana N, Okayama A, Shoiri S, Tsunetoshi Y, Tsuda K, Mueller NE, , 1993. Heterosexual transmission of human T cell leukemia/lymphoma virus type I among married couples in southwestern Japan: an initial report from the Miyazaki Cohort Study. J Infect Dis 167: 5765.[Crossref]
  31. Moriuchi H, Masuzaki H, Doi H, Katamine S, , 2013. Mother-to-child transmission of human T-cell lymphotropic virus type 1. Pediatr Infect Dis J 32: 175177.[Crossref]
  32. Roucoux DF, Wang B, Smith D, Nass CC, Smith J, Hutching ST, Newman B, Lee TH, Chafets DM, Murphy EL, HTLV Outcomes Study Investigators, , 2005. A prospective study of sexual transmission of human T lymphotropic virus (HTLV)-I and HTLV-II. J Infect Dis 191: 14901497.[Crossref]
  33. Melbye M, Poulsen AG, Gallo D, Pedersen JB, Biggar RJ, Larsen O, Dias F, Aaby P, , 1998. HTLV-1 infection in a population-based cohort of older persons in Guinea-Bissau, West Africa: risk factors and impact on survival. Int J Cancer 76: 293298.[Crossref]
  34. Buonfrate D, Formenti F, Perandin F, Bisoffi Z, , 2015. Novel approaches to the diagnosis of Strongyloides stercoralis infection. Clin Microbiol Infect 21: 543552.[Crossref]
  35. Hirata T, Kishimoto K, Kinjo N, Hokama A, Kinjo F, Fujita J, , 2007. Association between Strongyloides stercoralis infection and biliary tract cancer. Parasitol Res 101: 13451348.[Crossref]
  36. Hokama A, Adaniya H, Saito A, , 1998. Image of the month. Strongyroides stercoralis larvae. Gastroenterology 114: 6,230.[Crossref]
  37. Hennequin C, Pialoux G, Taillet BC, Caujolle B, Petite JP, , 1991. Anguilluliasis hyperinfection in a patient receiving corticosteroids: hepatic and biliary involvement. Gastroenterol Clin Biol 15: 8788.
  38. Delarocque AE, Hadengue A, Degott C, Vilgrain V, Erlinger S, Benhamou JP, , 1994. Biliary obstruction resulting from Strongyloides stercoralis infection. Report of a case. Gut 35: 705706.[Crossref]
  39. Jones N, Cocchiarella A, Faris K, Heard SO, , 2010. Pancreatitis associated with Strongyloides stercoralis infection in a patient chronically treated with corticosteroids. J Intensive Care Med 25: 172174.[Crossref]
  40. Suefuji H, Ohshima K, Hayabuchi N, Nakamura K, Kikuchi M, , 2003. HTLV-1 carriers with B-cell lymphoma of localized stage head and neck: prognosis, clinical and immunophathological features. Br J Haematol 123: 606612.[Crossref]
  41. Kozuru M, Uike N, Muta K, Goto T, Suehiro Y, Nagano M, , 1996. High occurrence of primary malignant neoplasms in patients with adult T-cell leukemia/lymphoma, their siblings, and their mothers. Cancer 78: 11191124.[Crossref]
  42. Beltran BE, Quiñones P, Morales D, Revilla JC, Alva JC, Castillo JJ, , 2012. Diffuse large B-cell lymphoma in human T-lymphotropic virus type 1 carriers. Leukemia Res Treat 2012: 262363.
  43. Tahaei SM, Mohebbi SR, Fatemi SR, Mohammadi P, Malek FN, Azimzadeh P, Almasi S, Mirsattari D, Zali MR, , 2011. Low frequency of human T-cell lymphotropic virus 1 antibodies in Iranian gastric cancer patients in comparison to controls. Asian Pac J Cancer Prev 12: 24472450.
  44. Mirsadraee M, Kalantari MR, Saffari A, Mahmoudi M, , 2007. Association of HTLV-1 infection and esophageal squamous cell carcinoma. J Gastrointest Cancer 38: 1518.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.15-0556
Loading
/content/journals/10.4269/ajtmh.15-0556
Loading

Data & Media loading...

  • Received : 31 Jul 2015
  • Accepted : 19 Oct 2015

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error