Volume 94, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Despite the increasing threat of dengue outbreaks in China, it is still considered as an imported disease and its introduction and/or circulation patterns remain obscure. On the basis of the most extensive phylogenetic analysis to date, we showed highly complex genetic diversity of dengue viruses (DENVs) in south China with up to 20 different clades/lineages from multiple serotypes co-circulating in the same year. Despite that most of these clades/lineages were resulted from imported cases, evidence of local persistence of DENV serotype 1 (DENV-1) was observed, indicating its potential endemicity in Guangdong province. This study, therefore, provided an overview of DENV genetic diversity and evolutionary dynamics in China, which will be useful for developing policies to prevent and control future dengue outbreaks in China.


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  1. Wu JY, Lun ZR, James AA, Chen XG, , 2010. Dengue fever in mainland China. Am J Trop Med Hyg 83: 664671.[Crossref] [Google Scholar]
  2. Jin X, Lee M, Shu J, , 2015. Dengue fever in China: an emerging problem demands attention. Emerg Microbes Infect 4: e3.[Crossref] [Google Scholar]
  3. Wu F, Liu Q, Lu L, Wang J, Song X, Ren D, , 2011. Distribution of Aedes albopictus (Diptera: Culicidae) in northwestern China. Vector Borne Zoonotic Dis 11: 11811186.[Crossref] [Google Scholar]
  4. Wang G, Zhang H, Cao X, Zhang X, Wang G, He Z, Yu C, Zhao T, , 2014. Using GARP to predict the range of Aedes aegypti in China. Southeast Asian J Trop Med Public Health 45: 290298. [Google Scholar]
  5. Sang S, Chen B, Wu H, Yang Z, Di B, Wang L, Tao X, Liu X, Liu Q, , 2015. Dengue is still an imported disease in China: a case study in Guangzhou. Infect Genet Evol 32: 178190.[Crossref] [Google Scholar]
  6. Zhao H, Zhao L, Jiang T, Li X, Fan H, Hong W, Zhang Y, Zhu Q, Ye Q, Tong Y, Cao W, Zhang F, Qin C, , 2014. Isolation and characterization of dengue virus serotype 2 from the large dengue outbreak in Guangdong, China in 2014. Sci China Life Sci 57: 11491155.[Crossref] [Google Scholar]
  7. Chen R, Vasilakis N, , 2011. Dengue—quo tu et quo vadis? Viruses 3: 15621608.[Crossref] [Google Scholar]
  8. Allicock OM, Lemey P, Tatem AJ, Pybus OG, Bennett SN, Mueller BA, Suchard MA, Foster JE, Rambaut A, Carrington CV, , 2012. Phylogeography and population dynamics of dengue viruses in the Americas. Mol Biol Evol 29: 15331543.[Crossref] [Google Scholar]
  9. Swofford DL, , 1998. PAUP*. Phylogenetic Analysis Using Parsimony (*and Other Methods). Version 4. Sunderland, MA: Sinauer Associates. [Google Scholar]
  10. Price MN, Dehal PS, Arkin AP, , 2010. FastTree 2—approximately maximum-likelihood trees for large alignments. PLoS One 5: e9490.[Crossref] [Google Scholar]
  11. Williams M, Mayer SV, Johnson WL, Chen R, Volkova E, Vilcarromero S, Widen SG, Wood TG, Suarez-Ognio L, Long KC, Hanley KA, Morrison AC, Vasilakis N, Halsey ES, , 2014. Lineage II of southeast Asian/American DENV-2 is associated with a severe dengue outbreak in the Peruvian Amazon. Am J Trop Med Hyg 91: 611620.[Crossref] [Google Scholar]
  12. Faye O, Ba Y, Faye O, Talla C, Diallo D, Chen R, Mondo M, Ba R, Macondo E, Siby T, Weaver SC, Diallo M, Sall AA, , 2014. Urban epidemic of dengue virus serotype 3 infection, Senegal, 2009. Emerg Infect Dis 20: 456459. [Google Scholar]
  13. Halstead SB, Porterfield JS, O'Rourke EJ, , 1980. Enhancement of dengue virus infection in monocytes by flavivirus antisera. Am J Trop Med Hyg 29: 638642. [Google Scholar]
  14. Halstead SB, , 1979. In vivo enhancement of dengue virus infection in rhesus monkeys by passively transferred antibody. J Infect Dis 140: 527533.[Crossref] [Google Scholar]
  15. Zhong NS, Zheng BJ, Li YM, Poon LLM, Xie ZH, Chan KH, Li PH, Tan SY, Chang Q, Xie JP, Liu XQ, Xu J, Li DX, Yuen KY, Peiris JSM, Guan Y, , 2003. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. Lancet 362: 13531358.[Crossref] [Google Scholar]
  16. Carrillo-Valenzo E, Danis-Lozano R, Velasco-Hernandez JX, Sanchez-Burgos G, Alpuche C, Lopez I, Rosales C, Baronti C, de Lamballerie X, Holmes EC, Ramos-Castañeda J, , 2010. Evolution of dengue virus in Mexico is characterized by frequent lineage replacement. Arch Virol 155: 14011412.[Crossref] [Google Scholar]

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Supplementary PDF

  • Received : 25 Jul 2015
  • Accepted : 31 Aug 2015
  • Published online : 06 Jan 2016

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