1921
Volume 94, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Artemisinin combination therapy (ACT) is the first line to treat uncomplicated malaria worldwide. Artemisinin treatment failures are on the rise in southeast Asia. Delayed parasite clearance after ACT is associated with mutations of the gene. Patients ( = 148) in five districts of northwest Ethiopia were enrolled in a 28-day ACT trial. We identified a unique mutation (R622I) in 3/125 (2.4%) samples. The three isolates with R622I were from Negade-Bahir and Aykel districts close to the Ethiopia–Sudan border. One of three patients with the mutant strain was parasitemic at day 3; however, all patients cleared parasites by day 28. Correlation between mutations and parasite clearance was not possible due to the low frequency of mutations in this study.

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2016-01-06
2017-11-23
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  • Received : 28 Jun 2015
  • Accepted : 02 Sep 2015

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