1921
Volume 94, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Despite Japan's temperate climate, a dengue outbreak occurred in Tokyo for the first time in over 70 years in 2014. We dissected this dengue outbreak based on phylogenetic analysis, travel interconnectivity, and environmental drivers for dengue epidemics. Comparing the available dengue virus 1 (DENV1) gene sequence from this outbreak with 3,282 unique DENV1 sequences in National Center for Biotechnology Information suggested that the DENV might have been imported from China, Indonesia, Singapore, or Vietnam. With travelers arriving into Japan, Guangzhou (China) may have been the source of DENV introduction, given that Guangzhou also reported a large-scale dengue outbreak in 2014. Coinciding with the 2014 outbreak, Tokyo's climate conditions permitted the amplification of vectors and the annual peak of vectorial capacity. Given suitable vectors and climate conditions in addition to increasing interconnectivity with endemic areas of Asia, Tokyo's 2014 outbreak did not come as a surprise and may foretell more to come.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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References

  1. Murray NE, Quam MB, Wilder-Smith A, , 2013. Epidemiology of dengue: past, present and future prospects. Clin Epidemiol 5: 299309. [Google Scholar]
  2. Wilder-Smith A, Quam M, Sessions O, Rocklov J, Liu-Helmersson J, Franco L, Khan K, , 2014. The 2012 dengue outbreak in Madeira: exploring the origins. Euro Surveill 19: 20718.[Crossref] [Google Scholar]
  3. Brady OJ, Golding N, Pigott DM, Kraemer MU, Messina JP, Reiner RC, Jr Scott TW, Smith DL, Gething PW, Hay SI, , 2014. Global temperature constraints on Aedes aegypti and Ae. albopictus persistence and competence for dengue virus transmission. Parasit Vectors 7: 338. [Google Scholar]
  4. Liu-Helmersson J, Stenlund H, Wilder-Smith A, Rocklöv J, , 2014. Vectorial capacity of Aedes aegypti: effects of temperature and implications for global dengue epidemic potential. PLoS One 9: e89783.[Crossref] [Google Scholar]
  5. Japanese Ministry of Health Labour and Welfare, 2014. For Domestic Infection Cases of Dengue Fever (38th Report). Available at: http://www.mhlw.go.jp/bunya/kenkou/kekkaku-kansenshou19/dl/20141031-01.pdf. Accessed January 21, 2015. [Google Scholar]
  6. Kutsuna S, Kato Y, Moi ML, Kotaki A, Ota M, Shinohara K, Kobayashi T, Yamamoto K, Fujiya Y, Mawatari M, Sato T, Kunimatsu J, Takeshita N, Hayakawa K, Kanagawa S, Takasaki T, Ohmagari N, , 2015. Autochthonous dengue fever, Tokyo, Japan, 2014. Emerg Infect Dis 21: 517520.[Crossref] [Google Scholar]
  7. Quam MB, Khan K, Sears J, Hu W, Rocklov J, Wilder-Smith A, , 2015. Estimating air travel-associated importations of dengue virus into Italy. J Travel Med 22: 186193.[Crossref] [Google Scholar]
  8. Katoh K, Misawa K, Kuma K, Miyata T, , 2002. MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Res 30: 30593066.[Crossref] [Google Scholar]
  9. Price MN, Dehal PS, Arkin AP, , 2010. FastTree 2—approximately maximum-likelihood trees for large alignments. PLoS One 5: e9490.[Crossref] [Google Scholar]
  10. Stamatakis A, , 2014. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics 30: 13121313.[Crossref] [Google Scholar]
  11. Japan National Tourist Organization, 2014. Number of Visitors to Japan from Overseas. Available at: http://www.tourism.jp/en/statistics/inbound/. Accessed February 16, 2015. [Google Scholar]
  12. Lambrechts L, Paaijmans KP, Fansiri T, Carrington LB, Kramer LD, Thomas MB, Scott TW, , 2011. Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegypti . Proc Natl Acad Sci USA 108: 74607465.[Crossref] [Google Scholar]
  13. Carrington LB, Seifert SN, Willits NH, Lambrechts L, Scott TW, , 2013. Large diurnal temperature fluctuations negatively influence Aedes aegypti (Diptera: Culicidae) life-history traits. J Med Entomol 50: 4351.[Crossref] [Google Scholar]
  14. NCAS British Atmospheric Data Centre, Met Office, 2012. Met Office Integrated Data Archive System (MIDAS) Land and Marine Surface Stations Data (1853–current). Available at: http://browse.ceda.ac.uk/browse/badc/ukmo-midas/data/GL/yearly_files/midas_glblwx-asia_201401-201412.txt. Accessed January 21, 2015. [Google Scholar]
  15. NCAS British Atmospheric Data Centre, Climatic Research Unit (CRU), 2014. Climatic Research Unit (CRU) Time-Series (TS) Version 3.22 of High Resolution Gridded Data of Month-by-Month Variation in Climate (Jan. 1901–Dec. 2013). Available at: http://browse.ceda.ac.uk/browse/badc/cru/data/cru_ts/cru_ts_3.22/data. Accessed January 21, 2015. [Google Scholar]
  16. Kobayashi M, Komagata O, Yonejima M, Maekawa Y, Hirabayashi K, Hayashi T, Nihei N, Yoshida M, Tsuda Y, Sawabe K, , 2014. Retrospective search for dengue vector mosquito Aedes albopictus in areas visited by a German traveler who contracted dengue in Japan. Int J Infect Dis 26: 135137.[Crossref] [Google Scholar]
  17. Guangdong Provincial Health and Family Planning Administrative Service Center, 2014. Guangdong Province Dengue Bulletin (December 15). Available at: http://www.gdwst.gov.cn/a/yiqingxx/2014121512665.html. Accessed February 10, 2015. [Google Scholar]
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Supplementary PDF

  • Received : 25 Jun 2015
  • Accepted : 03 Nov 2015
  • Published online : 03 Feb 2016

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