1921
Volume 94, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Despite the recommendation for the use of merozoite surface protein 1 (), merozoite surface protein 2 (), and glutamate-rich protein () genes as markers in drug efficacy studies by World Health Organization and their limited use in Bangladesh, the circulating population genetic structure has not yet been assessed in Bangladesh. This study presents a comprehensive report on the circulating population structure based on , , and polymorphic gene markers in Bangladesh. Among the 130 pretreatment (day 0) samples from seven malaria-endemic districts, 14 distinct genotypes were observed for , 20 for , and 13 for . Polyclonal infection was reported in 94.6% ( = 123) of the samples. Multiplicity of infection (MOI) for was the highest (1.5) among the MOIs of the markers. The heterozygosity for , , and was 0.89, 0.93, and 0.83, respectively. Data according to different malaria-endemic areas are also presented and discussed. Bangladesh is considered as a malaria-hypoendemic country. However, the prevalence of polyclonal infection and the genetic diversity of do not represent hypoendemicity.

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2016-06-01
2017-09-23
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  • Received : 17 Jun 2015
  • Accepted : 28 Mar 2016

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