Volume 94, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Dengue fever (DF) is a vector-borne disease caused by dengue viruses (DENVs). Epidemic dengue occurs intermittently in Taiwan. In 2014, Taiwan experienced its largest DF outbreak. There were 15,732 DF cases reported. There were a total of 136 dengue hemorrhagic fever (DHF) cases, of which 20 resulted in death. Most DF cases were reported in southern Taiwan. A total of 15,043 (96%) cases were from Kaohsiung, a modern city in southern Taiwan. This report reviews DF epidemics in Taiwan during 2005–2014. The correlation between DF and DHF along with temperature and precipitation were conjointly examined. We conclude that most dengue epidemics in Taiwan resulted from imported DF cases. Results indicate three main factors that may have been associated with this DF outbreak in Kaohsiung: an underground pipeline explosion combined with subsequent rainfall and higher temperature. These factors may have enhanced mosquito breeding activity, facilitating DENV transmission.


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  1. Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, Hunsperger E, Kroeger A, Margolis HS, Martinez E, Nathan MB, Pelegrino JL, Simmons C, Yoksan S, Peeling RW, , 2010. Dengue: a continuing global threat. Nat Rev Microbiol 8: S7S16.[Crossref] [Google Scholar]
  2. Huang JH, Su CL, Yang CF, Liao TL, Hsu TC, Chang SF, Lin CC, Shu PY, , 2012. Molecular characterization and phylogenetic analysis of dengue viruses imported into Taiwan during 2008–2010. Am J Trop Med Hyg 87: 349358.[Crossref] [Google Scholar]
  3. Shu PY, Su CL, Liao TL, Yang CF, Chang SF, Lin CC, Chang MC, Hu HC, Huang JH, , 2009. Molecular characterization of dengue viruses imported into Taiwan during 2003–2007: geographic distribution and genotype shift. Am J Trop Med Hyg 80: 10391046. [Google Scholar]
  4. Mustafa MS, Rasotgi V, Jain S, Gupta V, , 2015. Discovery of fifth serotype of dengue virus (DENV-5): a new public health dilemma in dengue control. Med J Armed Forces India 71: 6770.[Crossref] [Google Scholar]
  5. Lin CH, Schioler KL, Jepsen MR, Ho CK, Li SH, Konradsen F, , 2012. Dengue outbreaks in high-income area, Kaohsiung City, Taiwan, 2003–2009. Emerg Infect Dis 18: 16031611.[Crossref] [Google Scholar]
  6. Chao DY, Lin TH, Hwang KP, Huang JH, Liu CC, King CC, , 2004. 1998 dengue hemorrhagic fever epidemic in Taiwan. Emerg Infect Dis 10: 552554.[Crossref] [Google Scholar]
  7. CDC, 2015. Taiwan National Infectious Disease Statistics System for Dengue Virus. Center for Disease Control, Taiwan. Available at: http://nidss.cdc.gov.tw/en/SingleDisease.aspx?dc=1&dt=2&disease=061. [Google Scholar]
  8. Sui C, , 2014. Taiwan Gas Blasts in Kaohsiung Kill at Least 25. BBC News. Available at: http://www.bbc.com. [Google Scholar]
  9. Banu S, Hu W, Hurst C, Tong S, , 2011. Dengue transmission in the Asia-Pacific region: impact of climate change and socio-environmental factors. Trop Med Int Health 16: 598607.[Crossref] [Google Scholar]
  10. Sang S, Gu S, Bi P, Yang W, Yang Z, Xu L, Yang J, Liu X, Jiang T, Wu H, Chu C, Liu Q, , 2015. Predicting unprecedented dengue outbreak using imported cases and climatic factors in Guangzhou, 2014. PLoS Negl Trop Dis 9: e0003808.[Crossref] [Google Scholar]
  11. Mendez-Lazaro P, Muller-Karger FE, Otis D, McCarthy MJ, Pena-Orellana M, , 2014. Assessing climate variability effects on dengue incidence in San Juan, Puerto Rico. Int J Environ Res Public Health 11: 94099428.[Crossref] [Google Scholar]
  12. Jin X, Lee M, Shu J, , 2015. Dengue fever in China: an emerging problem demands attention. Emerg Microbes Infect 4: e3.[Crossref] [Google Scholar]
  13. Kong YY, Thay CH, Tin TC, Devi S, , 2006. Rapid detection, serotyping and quantitation of dengue viruses by TaqMan real-time one-step RT-PCR. J Virol Methods 138: 123130.[Crossref] [Google Scholar]
  14. Egger JR, Coleman PG, , 2007. Age and clinical dengue illness. Emerg Infect Dis 13: 924925.[Crossref] [Google Scholar]
  15. Thai KT, Nishiura H, Hoang PL, Tran NT, Phan GT, Le HQ, Tran BQ, Nguyen NV, de Vries PJ, , 2011. Age-specificity of clinical dengue during primary and secondary infections. PLoS Negl Trop Dis 5: e1180.[Crossref] [Google Scholar]
  16. Wang SF, Chang K, Lu RW, Wang WH, Chen YH, Chen M, Wu DC, Chen YM, , 2015. Large dengue virus type 1 outbreak in Taiwan. Emerg Microbes Infect 4: e46.[Crossref] [Google Scholar]
  17. Kuan MM, Chang FY, , 2012. Airport sentinel surveillance and entry quarantine for dengue infections following a fever screening program in Taiwan. BMC Infect Dis 12: 182.[Crossref] [Google Scholar]
  18. Tsuda Y, Maekawa Y, Ogawa K, Itokawa K, Komagata O, Sasaki T, Isawa H, Tomita T, Sawabe K, , 2015. Biting density and distribution of Aedes albopictus during the September 2014 outbreak of dengue fever in Yoyogi Park and the vicinity in Tokyo Metropolis, Japan. Jpn J Infect Dis. [Epub ahead of print, 2015 Mar 13]. [Google Scholar]
  19. Ng LC, Chem YK, Koo C, Mudin RN, Amin FM, Lee KS, Kheong CC, , 2015. 2013 dengue outbreaks in Singapore and Malaysia caused by different viral strains. Am J Trop Med Hyg 92: 11501155.[Crossref] [Google Scholar]

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Supplementary PDF

  • Received : 08 Jun 2015
  • Accepted : 07 Oct 2015
  • Published online : 06 Jan 2016

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