Volume 94, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



In South America, the presence of the RNA virus type 1 (LRV1) was described in and strains. The aim of this study was to determine the prevalence distribution of LRV1 in isolates in French Guiana given that, in this French overseas department, most infections are due to these parasite species. The presence of the virus was observed in 74% of spp. isolates, with a highest presence in the internal areas of the country.


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  1. Miller JH, Schwartzwelter JC, , 1960. Virus-like particles in an Entamoeba histolytica trophozoite. J Parasitol 46: 523524.[Crossref] [Google Scholar]
  2. Molyneux DH, , 1974. Virus-like particles in Leishmania parasites. Nature 249: 588589.[Crossref] [Google Scholar]
  3. Diamond LS, Mattern CF, , 1976. Protozoal viruses. Adv Virus Res 20: 87112.[Crossref] [Google Scholar]
  4. Wang AL, Wang CC, , 1986. Discovery of a specific double-stranded RNA virus in Giardia lamblia . Mol Biochem Parasitol 21: 269276.[Crossref] [Google Scholar]
  5. Wang AL, Wang CC, , 1986. The double-stranded RNA in Trichomonas vaginalis may originate from virus-like particles. Proc Natl Acad Sci USA 83: 79567960.[Crossref] [Google Scholar]
  6. Tipper DJ, Bostian KA, , 1984. Double-stranded ribonucleic acid killer systems in yeasts. Microbiol Rev 48: 125156. [Google Scholar]
  7. Tarr PI, Aline RF, Jr Smiley BL, Scholler J, Keithly J, Stuart K, , 1988. LR1: a candidate RNA virus of Leishmania . Proc Natl Acad Sci USA 85: 95729575.[Crossref] [Google Scholar]
  8. Cadd TL, Keenan MC, Patterson JL, , 1993. Detection of Leishmania RNA virus 1 proteins. J Virol 67: 56475650. [Google Scholar]
  9. Zangger H, Hailu A, Desponds C, Lye LF, Akopyants NS, Dobson DE, Ronet C, Ghalib H, Beverley SM, Fasel N, , 2014. Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus induce pro-inflammatory cytokine response. PLoS Negl Trop Dis 8: e2836.[Crossref] [Google Scholar]
  10. Guilbride L, Myler PJ, Stuart K, , 1992. Distribution and sequence divergence of LRV1 viruses among different Leishmania species. Mol Biochem Parasitol 54: 101104.[Crossref] [Google Scholar]
  11. Widmer G, Dooley S, , 1995. Phylogenetic analysis of Leishmania RNA virus and Leishmania suggests ancient virus-parasite association. Nucleic Acids Res 23: 23002304.[Crossref] [Google Scholar]
  12. Stuart KD, Weeks R, Guilbride L, Myler PJ, , 1992. Molecular organization of Leishmania RNA virus 1. Proc Natl Acad Sci USA 89: 85968600.[Crossref] [Google Scholar]
  13. Scheffter SM, Ro YT, Chung IK, Patterson JL, , 1995. The complete sequence of Leishmania RNA virus LRV2-1, a virus of an old world parasite strain. Virology 212: 8490.[Crossref] [Google Scholar]
  14. Scheffter S, Widmer G, Patterson JL, , 1994. Complete sequence of Leishmania RNA virus 1–4 and identification of conserved sequences. Virology 199: 479483.[Crossref] [Google Scholar]
  15. Rotureau B, Ravel C, Nacher M, Couppié P, Curtet I, Dedet JP, Carme B, , 2006. Molecular epidemiology of Leishmania (Viannia) guyanensis in French Guiana. J Clin Microbiol 44: 468473.[Crossref] [Google Scholar]
  16. Simon S, Veron V, Carme B, , 2010. Leishmania spp. identification by polymerase chain reaction–restriction fragment length polymorphism analysis and its applications in French Guiana. Diagn Microbiol Infect Dis 66: 175180.[Crossref] [Google Scholar]
  17. Ives A, Ronet C, Prevel F, Ruzzante G, Fuertes-Marraco S, Schutz F, Zangger H, Revaz-Breton M, Lye L, Hickerson SM, Beverley SM, Acha-Orbea H, Launois P, Fasel N, Masina S, , 2011. Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. Science 331: 775778.[Crossref] [Google Scholar]
  18. Salinas G, Zamora M, Stuart K, Saravia N, , 1996. Leishmania RNA viruses in Leishmania of the Viannia subgenus. Am J Trop Med Hyg 54: 425429. [Google Scholar]
  19. Saiz M, Llanos-Cuentas A, Echevarria J, Roncal N, Cruz M, Muniz MT, Lucas C, Wirth DF, Scheffter S, Magill AJ, Patterson JL, , 1998. Short report: detection of Leishmania virus in human biopsy samples of leishmaniasis from Peru. Am J Trop Med Hyg 58: 192194. [Google Scholar]
  20. Ogg MM, Carrion R, Jr Botelho AC, Mayrink W, Correa-Oliveira R, Patterson JL, , 2003. Short report: quantification of Leishmania virus RNA in clinical samples and its possible role in pathogenesis. Am J Trop Med Hyg 69: 309313. [Google Scholar]
  21. Bourreau E, Ginouves M, Prévot G, Hartley M, Gangneux J, Robert-Gangneux F, Dufour J, Marie DS, Bertolotti A, Pratlong F, Martin R, Schütz F, Couppié P, Fasel N, Ronet C, , 2015. Leishmania RNA virus presence in L. guyanensis parasites increases the risk of first-line treatment failure and symptomatic relapse. J Infect Dis. [epub ahead of print]. [Google Scholar]
  22. Pereira L de O, Maretti-Mira AC, Rodrigues KM, Lima RB, Oliveira-Neto MP, Cupolillo E, Pirmez C, de Oliveira MP, , 2013. Severity of tegumentary leishmaniasis is not exclusively associated with Leishmania RNA virus 1 infection in Brazil. Mem Inst Oswaldo Cruz 108: 665667.[Crossref] [Google Scholar]
  23. Rotureau B, Gaborit P, Issaly J, Carinci R, Fouque F, Carme B, , 2006. Diversity and ecology of sand flies (Diptera: Psychodidae: Phlebotominae) in coastal French Guiana. Am J Trop Med Hyg 75: 6269. [Google Scholar]
  24. Fouque F, Gaborit P, Issaly J, Carinci R, Gantier JC, Ravel C, Dedet JP, , 2007. Phlebotomine sand flies (Diptera: Psychodidae) associated with changing patterns in the transmission of the human cutaneous leishmaniasis in French Guiana. Mem Inst Oswaldo Cruz 102: 3540.[Crossref] [Google Scholar]
  25. Croft SL, Molyneux DH, , 1979. Studies on the ultrastructure, virus-like particles and infectivity of Leishmania hertigi . Ann Trop Med Parasitol 73: 213226.[Crossref] [Google Scholar]
  26. Ronet C, Beverley SM, Fasel N, , 2011. Muco-cutaneous leishmaniasis in the new world: the ultimate subversion. Virulence 2: 547552.[Crossref] [Google Scholar]
  27. Ives A, Masina S, Castiglioni P, Prevel F, Revaz-Breton M, Hartley MA, Launois P, Fasel N, Ronet C, , 2014. MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden. PLoS One 9: e96766.[Crossref] [Google Scholar]

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  • Received : 05 Jun 2015
  • Accepted : 20 Sep 2015
  • Published online : 06 Jan 2016

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