Volume 93, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Murine typhus is a flea-borne febrile illness caused by . Although often accompanied by rash, an inoculation lesion has not been observed as it is with many tick- and mite-transmitted rickettsioses. We describe a patient with murine typhus and an unusual cutaneous manifestation at the site of rickettsial inoculation.


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  1. Blanton LS, Dumler JS, Walker DH, Bennett JE, Dolin R, Blaser MJ, , 2015. Rickettsia typhi (murine typhus). , eds. Principles and Practice of Infectious Diseases. Philadelphia, PA: Elsevier, 22212224.
  2. Strandtmann RW, Eben DJ, , 1953. A survey of typhus in rats and rat ectoparasites in Galveston, Texas. Tex Rep Biol Med 11: 144151.
  3. Blanton LS, Vohra RF, Bouyer DH, Walker DH, , 2015. Reemergence of murine typhus in Galveston, Texas, USA, 2013. Emerg Infect Dis 21: 484486.[Crossref]
  4. Dumler JS, Taylor JP, Walker DH, , 1991. Clinical and laboratory features of murine typhus in south Texas, 1980 through 1987. JAMA 266: 13651370.[Crossref]
  5. Bernabeu-Wittel M, Pachon J, Alarcon A, Lopez-Cortes LF, Viciana P, Jimenez-Mejias ME, Villanueva JL, Torronteras R, Caballero-Granado FJ, , 1999. Murine typhus as a common cause of fever of intermediate duration: a 17-year study in the south of Spain. Arch Intern Med 159: 872876.[Crossref]
  6. Chaliotis G, Kritsotakis EI, Psaroulaki A, Tselentis Y, Gikas A, , 2012. Murine typhus in central Greece: epidemiological, clinical, laboratory, and therapeutic-response features of 90 cases. Int J Infect Dis 16: e591e596.[Crossref]
  7. Gikas A, Doukakis S, Pediaditis J, Kastanakis S, Psaroulaki A, Tselentis Y, , 2002. Murine typhus in Greece: epidemiological, clinical, and therapeutic data from 83 cases. Trans R Soc Trop Med Hyg 96: 250253.[Crossref]
  8. Miller ES, Beeson PB, , 1946. Murine typhus fever. Medicine 25: 115.[Crossref]
  9. Phongmany S, Rolain JM, Phetsouvanh R, Blacksell SD, Soukkhaseum V, Rasachack B, Phiasakha K, Soukkhaseum S, Frichithavong K, Chu V, Keolouangkhot V, Martinez-Aussel B, Chang K, Darasavath C, Rattanavong O, Sisouphone S, Mayxay M, Vidamaly S, Parola P, Thammavong C, Heuangvongsy M, Syhavong B, Raoult D, White NJ, Newton PN, , 2006. Rickettsial infections and fever, Vientiane, Laos. Emerg Infect Dis 12: 256262.[Crossref]
  10. Shaked Y, Samra Y, Maeir MK, Rubinstein E, , 1988. Murine typhus and spotted fever in Israel in the eighties: retrospective analysis. Infection 16: 283287.[Crossref]
  11. Stuart BM, Pullen RL, , 1945. Endemic (murine) typhus fever: clinical observations of 180 cases. Ann Intern Med 23: 520536.[Crossref]
  12. Tselentis Y, Babalis TL, Chrysanthis D, Gikas A, Chaliotis G, Raoult D, , 1992. Clinicoepidemiological study of murine typhus on the Greek island of Evia. Eur J Epidemiol 8: 268272.[Crossref]
  13. Zimmerman MD, Murdoch DR, Rozmajzl PJ, Basnyat B, Woods CW, Richards AL, Belbase RH, Hammer DA, Anderson TP, Reller LB, , 2008. Murine typhus and febrile illness, Nepal. Emerg Infect Dis 14: 16561659.[Crossref]
  14. Walker DH, Feng HM, Ladner S, Billings AN, Zaki SR, Wear DJ, Hightower B, , 1997. Immunohistochemical diagnosis of typhus rickettsioses using an anti-lipopolysaccharide monoclonal antibody. Mod Pathol 10: 10381042.
  15. Henry KM, Jiang J, Rozmajzl PJ, Azad AF, Macaluso KR, Richards AL, , 2007. Development of quantitative real-time PCR assays to detect Rickettsia typhi and Rickettsia felis, the causative agents of murine typhus and flea-borne spotted fever. Mol Cell Probes 21: 1723.[Crossref]
  16. Labruna MB, Whitworth T, Horta MC, Bouyer DH, McBride JW, Pinter A, Popov V, Gennari SM, Walker DH, , 2004. Rickettsia species infecting Amblyomma cooperi ticks from an area in the state of Sao Paulo, Brazil, where Brazilian spotted fever is endemic. J Clin Microbiol 42: 9098.[Crossref]
  17. Montenegro MR, Mansueto S, Hegarty BC, Walker DH, , 1983. The histology of “taches noires” of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. Virchows Arch A Pathol Anat Histopathol 400: 309317.[Crossref]
  18. Murphy JR, Wisseman CL, Jr Fiset P, , 1978. Mechanisms of immunity in typhus infection: some characteristics of Rickettsia mooseri infection of guinea pigs. Infect Immun 21: 417424.
  19. La Scola B, Bechah Y, Lepidi H, Raoult D, , 2009. Prediction of rickettsial skin eschars in humans using an experimental guinea pig model. Microb Pathog 47: 128133.[Crossref]
  20. Everritt MG, Bhatt PN, Fox JP, , 1954. Infection of man with avirulent rickettsiae of epidemic typhus (strain E). Am J Hyg 59: 6073.
  21. Azad AF, Traub R, , 1989. Experimental transmission of murine typhus by Xenopsylla cheopis flea bites. Med Vet Entomol 3: 429433.[Crossref]

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  • Received : 21 May 2015
  • Accepted : 29 Jul 2015

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