Volume 93, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Ackee apple fruit is a native fruit to Jamaica and some parts of west Africa. Its toxicity known as “Jamaican vomiting sickness” dates back to the nineteenth century. However, there is a dearth of reported published data on toxicity from Nigeria where it is popularly known in the southwest as “ishin.” We report a case series of eight previously well Nigerian siblings who presented at various intervals after ingestion of roasted seeds and aril of the ackee fruit.


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  1. Grunes DE, Scordi-bello I, Suh M, Florman S, Yao J, Fiel MI, Thung SN, , 2012. Fulminant hepatic failure attributed to ackee fruit ingestion in a patient with sickle cell trait. Case Rep Transplant 2012: 739238. [Google Scholar]
  2. Atolani O, Olatunji GA, Fabiyi OA, , 2009. Blighia sapida; the plant and its hypoglycins: an overview. J Sci Res XXXIX: 1525. [Google Scholar]
  3. Emanuel MA, Benkeblia N, , 2012. Adding Value to Tropical Fruits—The Case of the Jamaican Ackee Industry: Lessons for Policy and Practice. Wageningen, The Netherlands: Knowledge for Development. [Google Scholar]
  4. Barceloux DG, , 2009. Ackee fruit and Jamaican vomiting sickness (Blighia sapida Köenig). Dis Mon 55: 318326.[Crossref] [Google Scholar]
  5. Meda HA, Diallo B, Buchet J, Lison D, Barennes H, Ouangré A, Sanou M, Cousens S, Tall F, Van de Perre P, , 1999. Epidemic of fatal encephalopathy in preschool children in Burkina Faso and consumption of unripe ackee (Blighia sapida) fruit. Lancet 353: 536540.[Crossref] [Google Scholar]
  6. Joskow R, Belson M, Vesper H, Backer L, Rubin C, , 2006. Ackee fruit poisoning: an outbreak investigation in Haiti 2000–2001 and review of the literature. Clin Toxicol 44: 267273.[Crossref] [Google Scholar]
  7. Hassal CH, Reyle K, , 1955. Hypoglycin A and B, two biologically active polypeptides from Blighia sapida . Biochem J 60: 334339.[Crossref] [Google Scholar]
  8. Tanaka K, Kean EA, Johnson B, , 1976. Jamaican vomiting sickness—biochemical investigation of two cases. N Engl J Med 295: 461467.[Crossref] [Google Scholar]
  9. Golden KD, Williams OJ, , 2002. High-performance liquid chromatographic analysis of amino acids in ackee fruit with emphasis on the toxic amino acid hypoglycin A. J Chromatogr Sci 40: 441446.[Crossref] [Google Scholar]
  10. Kean EA, Hare ER, , 1980. γ-Glutamyl transpeptidase of the ackee plant. Phytochemistry 19: 199203.[Crossref] [Google Scholar]
  11. Adepoju AJ, Esan AO, Bello MO, , 2013. Variation in the chemical parameters of oil extracted from arils of Blighia sapida (ackee) with the degree of fruit ripeness. Int J Basic Appl Sci 2: 109114. [Google Scholar]

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  • Received : 11 May 2015
  • Accepted : 01 Jul 2015
  • Published online : 04 Nov 2015

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