1921
Volume 94, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Sporotrichosis is a polymorphic disease of humans and animals, which is acquired via traumatic inoculation of propagules into cutaneous or subcutaneous tissue. The etiological agents are in a clinical complex, which includes , , , and , each of which has specific epidemiological and virulence characteristics. Classical manifestation in humans includes a fixed localized lesion at the site of trauma plus lymphocutaneous sporotrichosis with fungal spreading along the lymphatic channels. Atypical sporotrichosis is a challenge to diagnosis because it can mimic many other dermatological diseases. We report an unusual, itraconazole-resistant cutaneous lesion of sporotrichosis in a 66-year-old Brazilian man. Histopathological examination of the skin revealed vascular and fibroblastic proliferation with chronic granulomatous infiltrate composed of multinucleated giant cells. were isolated from the skin lesion, and phylogenetic analyses confirmed it to be sporotrichosis due to , a widespread pathogen. Immunoblotting analysis showed several IgG-reactive molecules in autochthonous preparations of the whole cellular proteins (160, 80, 60, 55, 46, 38, 35, and 30 kDa) and exoantigen (35 and 33 kDa). The patient was first unsuccessfully treated with daily itraconazole, and then successfully treated with potassium iodide.

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References

  1. Chakrabarti A, Bonifaz A, Gutierrez-Galhardo MC, Mochizuki T, Li S, , 2015. Global epidemiology of sporotrichosis. Med Mycol 53: 314.[Crossref] [Google Scholar]
  2. Zhang Y, Hagen F, Stielow B, Rodrigues AM, Samerpitak K, Zhou X, Feng P, Yang L, Chen M, Deng S, Li S, Liao W, Li R, Li F, Meis JF, Guarro J, Teixeira M, Al-Zahrani HS, Camargo ZP, Zhang L, de Hoog GS, , 2015. Phylogeography and evolutionary patterns in Sporothrix spanning more than 14000 human and animal case reports. Persoonia 35: 120.[Crossref] [Google Scholar]
  3. Bonifaz A, Vázquez-González D, , 2013. Diagnosis and treatment of lymphocutaneous sporotrichosis: what are the options? Curr Fungal Infect Rep 7: 252259.[Crossref] [Google Scholar]
  4. Pappas PG, Tellez I, Deep AE, Nolasco D, Holgado W, Bustamante B, , 2000. Sporotrichosis in Peru: description of an area of hyperendemicity. Clin Infect Dis 30: 6570.[Crossref] [Google Scholar]
  5. Marimon R, Cano J, Gené J, Sutton DA, Kawasaki M, Guarro J, , 2007. Sporothrix brasiliensis, S. globosa, and S. mexicana, three new Sporothrix species of clinical interest. J Clin Microbiol 45: 31983206.[Crossref] [Google Scholar]
  6. Marimon R, Gené J, Cano J, Guarro J, , 2008. Sporothrix luriei: a rare fungus from clinical origin. Med Mycol 46: 621625.[Crossref] [Google Scholar]
  7. Zhou X, Rodrigues AM, Feng P, de Hoog GS, , 2014. Global ITS diversity in the Sporothrix schenckii complex. Fungal Divers 66: 153165. [Google Scholar]
  8. Rodrigues AM, de Melo Teixeira M, de Hoog GS, Schubach TMP, Pereira SA, Fernandes GF, Bezerra LML, Felipe MS, de Camargo ZP, , 2013. Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks. PLoS Negl Trop Dis 7: e2281.[Crossref] [Google Scholar]
  9. Rodrigues AM, de Hoog GS, Zhang Y, Camargo ZP, , 2014. Emerging sporotrichosis is driven by clonal and recombinant Sporothrix species. Emerg Microbes Infect 3: e32.[Crossref] [Google Scholar]
  10. Madrid H, Cano J, Gene J, Bonifaz A, Toriello C, Guarro J, , 2009. Sporothrix globosa, a pathogenic fungus with widespread geographical distribution. Rev Iberoam Micol 26: 218222.[Crossref] [Google Scholar]
  11. Yu X, Wan Z, Zhang Z, Li F, Li R, Liu X, , 2013. Phenotypic and molecular identification of Sporothrix isolates of clinical origin in northeast China. Mycopathologia 176: 6774.[Crossref] [Google Scholar]
  12. Camacho E, León-Navarro I, Rodríguez-Brito S, Mendoza M, Niño-Vega GA, , 2015. Molecular epidemiology of human sporotrichosis in Venezuela reveals high frequency of Sporothrix globosa . BMC Infect Dis 15: 94.[Crossref] [Google Scholar]
  13. Fernandes GF, dos Santos PO, Rodrigues AM, Sasaki AA, Burger E, de Camargo ZP, , 2013. Characterization of virulence profile, protein secretion and immunogenicity of different Sporothrix schenckii sensu stricto isolates compared with S. globosa and S. brasiliensis species. Virulence 4: 241249.[Crossref] [Google Scholar]
  14. Arrillaga-Moncrieff I, Capilla J, Mayayo E, Marimon R, Mariné M, Gené J, Cano J, Guarro J, , 2009. Different virulence levels of the species of Sporothrix in a murine model. Clin Microbiol Infect 15: 651655.[Crossref] [Google Scholar]
  15. Rodrigues AM, de Hoog GS, de Cassia Pires D, Brihante RSN, da Costa Sidrim JJ, Gadelha MF, Colombo AL, de Camargo ZP, , 2014. Genetic diversity and antifungal susceptibility profiles in causative agents of sporotrichosis. BMC Infect Dis 14: 219.[Crossref] [Google Scholar]
  16. Borba-Santos LP, Rodrigues AM, Gagini TB, Fernandes GF, Castro R, de Camargo ZP, Nucci M, Lopes-Bezerra LM, Ishida K, Rozental S, , 2015. Susceptibility of Sporothrix brasiliensis isolates to amphotericin B, azoles, and terbinafine. Med Mycol 53: 178188.[Crossref] [Google Scholar]
  17. Rodrigues AM, de Hoog S, de Camargo ZP, , 2013. Emergence of pathogenicity in the Sporothrix schenckii complex. Med Mycol 51: 405412.[Crossref] [Google Scholar]
  18. Rodrigues AM, Najafzadeh MJ, de Hoog GS, de Camargo ZP, , 2015. Rapid identification of emerging human-pathogenic Sporothrix species with rolling circle amplification. Front Microbiol 6: 1385. [Google Scholar]
  19. Katoh K, Standley DM, , 2013. MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Mol Biol Evol 30: 772780.[Crossref] [Google Scholar]
  20. Marimon R, Serena C, Gené J, Cano J, Guarro J, , 2008. In vitro antifungal susceptibilities of five species of Sporothrix . Antimicrob Agents Chemother 52: 732734.[Crossref] [Google Scholar]
  21. Rodrigues AM, Kubitschek-Barreira PH, Fernandes GF, de Almeida SR, Lopes-Bezerra LM, de Camargo ZP, , 2015. Immunoproteomic analysis reveals a convergent humoral response signature in the Sporothrix schenckii complex. J Proteomics 115: 822.[Crossref] [Google Scholar]
  22. Fernandes GF, Amaral CCD, Sasaki A, Godoy PM, De Camargo ZP, , 2009. Heterogeneity of proteins expressed by Brazilian Sporothrix schenckii isolates. Med Mycol 47: 855861.[Crossref] [Google Scholar]
  23. Rodrigues AM, Fernandes GF, Araujo LM, Della Terra PP, Dos Santos PO, Pereira SA, Schubach TM, Burger E, Lopes-Bezerra LM, de Camargo ZP, , 2015. Proteomics-based characterization of the humoral immune response in sporotrichosis: toward discovery of potential diagnostic and vaccine antigens. PLoS Negl Trop Dis 9: e0004016.[Crossref] [Google Scholar]
  24. Scott EN, Muchmore HG, , 1989. Immunoblot analysis of antibody responses to Sporothrix schenckii . J Clin Microbiol 27: 300304. [Google Scholar]
  25. Rodrigues AM, Bagagli E, de Camargo ZP, Bosco SMG, , 2014. Sporothrix schenckii sensu stricto isolated from soil in an armadillo's burrow. Mycopathologia 177: 199206. [Google Scholar]
  26. Rodrigues AM, Cruz Choappa R, Fernandes GF, De Hoog GS, Camargo ZP, , 2016. Sporothrix chilensis sp. nov. (Ascomycota: Ophiostomatales), a soil-borne agent of human sporotrichosis with mild-pathogenic potential to mammals. Fungal Biol 120: 246264.[Crossref] [Google Scholar]
  27. Vismer HF, Hull PR, , 1997. Prevalence, epidemiology and geographical distribution of Sporothrix schenckii infections in Gauteng, South Africa. Mycopathologia 137: 137143.[Crossref] [Google Scholar]
  28. de Oliveira MM, de Almeida-Paes R, de Medeiros Muniz M, de Lima Barros MB, Galhardo MC, Zancope-Oliveira RM, , 2010. Sporotrichosis caused by Sporothrix globosa in Rio De Janeiro, Brazil: case report. Mycopathologia 169: 359363.[Crossref] [Google Scholar]
  29. Song Y, Li SS, Zhong SX, Liu YY, Yao L, Huo SS, , 2013. Report of 457 sporotrichosis cases from Jilin province, northeast China, a serious endemic region. J Eur Acad Dermatol Venereol 27: 313318.[Crossref] [Google Scholar]
  30. Castro RA, Kubitschek-Barreira PH, Teixeira PAC, Sanches GF, Teixeira MM, Quintella LP, Almeida SR, Costa RO, Camargo ZP, Felipe MSS, de Souza W, Lopes-Bezerra LM, , 2013. Differences in cell morphometry, cell wall topography and Gp70 expression correlate with the virulence of Sporothrix brasiliensis clinical isolates. PLoS One 8: e75656.[Crossref] [Google Scholar]
  31. de Macedo PM, Lopes-Bezerra LM, Bernardes-Engemann AR, Orofino-Costa R, , 2015. New posology of potassium iodide for the treatment of cutaneous sporotrichosis: study of efficacy and safety in 102 patients. J Eur Acad Dermatol Venereol 29: 719724.[Crossref] [Google Scholar]
  32. Orofino-Costa R, de Macedo PM, Bernardes-Engemann AR, , 2015. Hyperendemia of sporotrichosis in the Brazilian southeast: learning from clinics and therapeutics. Curr Fungal Infect Rep 9: 220228.[Crossref] [Google Scholar]
  33. Ottonelli Stopiglia CD, Magagnin CM, Castrillon MR, Mendes SD, Heidrich D, Valente P, Scroferneker ML, , 2014. Antifungal susceptibilities and identification of species of the Sporothrix schenckii complex isolated in Brazil. Med Mycol 52: 5664. [Google Scholar]
  34. Silveira CP, Torres-Rodríguez JM, Alvarado-Ramírez E, Murciano-Gonzalo F, Dolande M, Panizo M, Reviakina V, , 2009. MICs and minimum fungicidal concentrations of amphotericin B, itraconazole, posaconazole and terbinafine in Sporothrix schenckii . J Med Microbiol 58: 16071610.[Crossref] [Google Scholar]
  35. de Macedo PM, Sztajnbok DC, Camargo ZP, Rodrigues AM, Lopes-Bezerra LM, Bernardes-Engemann AR, Orofino-Costa R, , 2015. Dacryocystitis due to Sporothrix brasiliensis: a case report of a successful clinical and serological outcome with low-dose potassium iodide treatment and oculoplastic surgery. Br J Dermatol 172: 11161119.[Crossref] [Google Scholar]
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  • Received : 07 Apr 2015
  • Accepted : 09 Jan 2016

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