1921
Volume 93, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Large scale antibody responses in malaria remains unexplored in the endemic setting. Protein microarray analysis of asexual-stage was used to identify antigens recognized in sera from residents of hypoendemic Peruvian Amazon. Over 24 months, of 106 participants, 91 had two symptomatic malaria episodes, 11 had three episodes, 3 had four episodes, and 1 had five episodes. relapse was distinguished from reinfection by a merozoite surface protein-3α restriction fragment length polymorphism polymerase chain reaction (MSP3α PCR-RFLP) assay. Notably, reinfection subjects did not have higher reactivity to the entire set of recognized blood-stage antigens than relapse subjects, regardless of the number of malaria episodes. The most highly recognized proteins were MSP 4, 7, 8, and 10 (PVX_003775, PVX_082650, PVX_097625, and PVX_114145); sexual-stage antigen s16 (PVX_000930); early transcribed membrane protein (PVX_090230); tryptophan-rich antigen (Pv-fam-a) (PVX_092995); apical merozoite antigen 1 (PVX_092275); and proteins of unknown function (PVX_081830, PVX_117680, PVX_118705, PVX_121935, PVX_097730, PVX_110935, PVX_115450, and PVX_082475). Genes encoding reactive proteins exhibited a significant enrichment of non-synonymous nucleotide variation, an observation suggesting immune selection. These data identify candidates for seroepidemiological tools to support malaria elimination efforts in -endemic regions.

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2015-10-07
2017-11-22
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Supplementary Data

Supplementary Table 1

Supplementary Table 2

  • Received : 24 Mar 2015
  • Accepted : 13 May 2015

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