Volume 93, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A community-based immunization coverage survey is the standard way to estimate effective vaccination delivery to a target population in a region. Accompanying serosurveys can provide objective measures of protective immunity against vaccine-preventable diseases but pose considerable challenges with respect to specimen collection and preservation and community compliance. We performed serosurveys coupled to immunization coverage surveys in three administrative districts (woredas) in rural Ethiopia. Critical to the success of this effort were serosurvey equipment and supplies, team composition, and tight coordination with the coverage survey. Application of these techniques to future studies may foster more widespread use of serosurveys to derive more objective assessments of vaccine-derived seroprotection and monitor and compare the performance of immunization services in different districts of a country.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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  1. World Health Organization, 2005. Immunization Coverage Cluster Survey—Reference Manual Geneva, Switzerland: WHO Document Production Services.
    [Google Scholar]
  2. Clopper CJ, Pearson ES, 1934. The use of confidence or fiducial limits illustrated in the case of the binomial. Biometrika 26: 404413.[Crossref]
    [Google Scholar]
  3. Central Statistical Agency, ICF International, 2011. Ethiopia Demographic and Health Survey, 2011. Addis Ababa, Ethiopia and Calverton, MD: Central Statistical Agency and ICF International.
    [Google Scholar]
  4. Ministry of Health FDRoE, 2013. Training Course on the Management of Severe Acute Malnutrition: Participant Module, 2nd edition. Addis Ababa, Ethiopia: Ministry of Health, Federal Democratic Republic of Ethiopia.
    [Google Scholar]
  5. Enquselassie F, Ayele W, Dejene A, Messele T, Abebe A, Cutts FT, Nokes DJ, 2003. Seroepidemiology of measles in Addis Ababa, Ethiopia: implications for control through vaccination. Epidemiol Infect 130: 507519.
    [Google Scholar]
  6. Murhekar MV, Bitragunta S, Hutin Y, Chakravarty A, Sharma HJ, Gupte MD, 2009. Immunization coverage and immunity to diphtheria and tetanus among children in Hyderabad, India. J Infect 58: 191196.
    [Google Scholar]

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  • Received : 13 Mar 2015
  • Accepted : 07 Apr 2015
  • Published online : 05 Aug 2015
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