Volume 93, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Leptospirosis is a potentially severe illness in returned travelers. Patients often present with fever, headache, and neck pain, which may lead to a workup for meningitis including the acquisition of cerebrospinal fluid (CSF). Although DNA has been detected in CSF by polymerase chain reaction (PCR), little data exist regarding the utility of testing CSF in addition to serum or plasma obtained on presentation. In this report, we present two cases of leptospirosis in returned travelers presenting with fever and headache. Our first patient had neutrophilic meningitis, and was detectable only in CSF obtained on admission. The second patient had a normal CSF profile, but was detected in CSF at a bacterial load 5- to 10-fold higher than that in plasma. CSF is an important specimen for the diagnosis of by molecular methods and may yield an actionable diagnosis in the absence of leptospiremia.


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  • Received : 03 Mar 2015
  • Accepted : 21 Apr 2015
  • Published online : 05 Aug 2015

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