1921
Volume 93, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

An increased incidence of monkeypox (MPX) infections in the Democratic Republic of the Congo was noted by the regional surveillance system in October 2013. Little information exists regarding how MPX is introduced into the community and the factors associated with transmission within the household. Sixty-eight wild animals were collected and tested for . Two of three rope squirrels ( sp.) were positive for antibodies to ; however, no increased risk was associated with the consumption or preparation of rope squirrels. A retrospective cohort investigation and a case–control investigation were performed to identify risk factors affecting the introduction of monkeypox virus (MPXV) into the community and transmission within the home. School-age males were the individuals most frequently identified as the first person infected in the household and were the group most frequently affected overall. Risk factors of acquiring MPXV in a household included sleeping in the same room or bed, or using the same plate or cup as the primary case. There was no significant risk associated with eating or processing of wild animals. Activities associated with an increased risk of MPXV transmission all have potential for virus exposure to the mucosa.

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2015-08-05
2017-09-23
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References

  1. Jezek Z, Szczeniowski M, Paluku KM, Mutombo M, , 1987. Human monkeypox: clinical features of 282 patients. J Infect Dis 156: 293298.[Crossref]
  2. Hutson CL, Carroll DS, Gallardo-Romero N, Weiss S, Clemmons C, Hughes CM, Salzer JS, Olson VA, Abel J, Karem KL, Damon IK, , 2011. Monkeypox disease transmission in an experimental setting: prairie dog animal model. PLoS One 6: e28295.[Crossref]
  3. Reynolds MG, Yorita KL, Kuehnert MJ, Davidson WB, Huhn GD, Holman RC, Damon IK, , 2006. Clinical manifestations of human monkeypox influenced by route of infection. J Infect Dis 194: 773780.[Crossref]
  4. Learned LA, Reynolds MG, Wassa DW, Li Y, Olson VA, Karem K, Stempora LL, Braden ZH, Kline R, Likos A, Libama F, Moudzeo H, Bolanda JD, Tarangonia P, Boumandoki P, Formenty P, Harvey JM, Damon IK, , 2005. Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003. Am J Trop Med Hyg 73: 428434.
  5. Jezek Z, Arita I, Mutombo M, Dunn C, Nakano JH, Szczeniowski M, , 1986. Four generations of probable person-to-person transmission of human monkeypox. Am J Epidemiol 123: 10041012.[Crossref]
  6. Formenty P, Muntasir MO, Damon I, Chowdhary V, Opoka ML, Monimart C, Mutasim EM, Manuguerra JC, Davidson WB, Karem KL, Cabeza J, Wang S, Malik MR, Durand T, Khalid A, Rioton T, Kuong-Ruay A, Babiker AA, Karsani ME, Abdalla MS, , 2010. Human monkeypox outbreak caused by novel virus belonging to Congo Basin clade, Sudan, 2005. Emerg Infect Dis 16: 15391545.[Crossref]
  7. Reynolds MG, Carroll DS, Karem KL, , 2012. Factors affecting the likelihood of monkeypox's emergence and spread in the post-smallpox era. Curr Opin Virol 2: 335343.[Crossref]
  8. Arita I, Jezek Z, Khodakevich L, Ruti K, , 1985. Human monkeypox: a newly emerged Orthopoxvirus zoonosis in the tropical rain forests of Africa. Am J Trop Med Hyg 34: 781789.
  9. Hutin YJ, Williams RJ, Malfait P, Pebody R, Loparev VN, Ropp SL, Rodriguez M, Knight JC, Tshioko FK, Khan AS, Szczeniowski MV, Esposito JJ, , 2001. Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. Emerg Infect Dis 7: 434438.[Crossref]
  10. Khodakevich L, Jezek Z, Messinger D, , 1988. Monkeypox virus: ecology and public health significance. Bull World Health Organ 66: 747752.
  11. Sarkar JK, Mitra AC, Mukherjee MK, De SK, , 1973. Virus excretion in smallpox. 2. Excretion in the throats of household contacts. Bull World Health Organ 48: 523527.
  12. Khodakevich L, Jezek Z, Kinzanzka K, , 1986. Isolation of monkeypox virus from wild squirrel infected in nature. Lancet 1: 9899.[Crossref]
  13. Radonic A, Metzger S, Dabrowski PW, Couacy-Hymann E, Schuenadel L, Kurth A, Matz-Rensing K, Boesch C, Leendertz FH, Nitsche A, , 2014. Fatal monkeypox in wild-living sooty mangabey, Cote d'Ivoire, 2012. Emerg Infect Dis 20: 10091011.[Crossref]
  14. Kulesh DA, Loveless BM, Norwood D, Garrison J, Whitehouse CA, Hartmann C, Mucker E, Miller D, Wasieloski LP, Jr Huggins J, Huhn G, Miser LL, Imig C, Martinez M, Larsen T, Rossi CA, Ludwig GV, , 2004. Monkeypox virus detection in rodents using real-time 3′-minor groove binder TaqMan assays on the Roche LightCycler. Lab Invest 84: 12001208.[Crossref]
  15. Li Y, Olson VA, Laue T, Laker MT, Damon IK, , 2006. Detection of monkeypox virus with real-time PCR assays. J Clin Virol 36: 194203.[Crossref]
  16. Jezek Z, Fenner F, , 1988. Human monkeypox. Monogr Virol 17: 111134.[Crossref]
  17. Reynolds MG, Carroll DS, Olson VA, Hughes C, Galley J, Likos A, Montgomery JM, Suu-Ire R, Kwasi MO, Jeffrey Root J, Braden Z, Abel J, Clemmons C, Regnery R, Karem K, Damon IK, , 2010. A silent enzootic of an orthopoxvirus in Ghana, West Africa: evidence for multi-species involvement in the absence of widespread human disease. Am J Trop Med Hyg 82: 746754.[Crossref]
  18. Khodakevich L, Szczeniowski M, Manbu-ma D, Jezek Z, Marennikova S, Nakano J, Messinger D, , 1987. The role of squirrels in sustaining monkeypox virus transmission. Trop Geogr Med 39: 115122.
  19. Khodakevich L, Szczeniowski M, Nambu-ma D, Jezek Z, Marennikova S, Nakano J, Meier F, , 1987. Monkeypox virus in relation to the ecological features surrounding human settlements in Bumba zone, Zaire. Trop Geogr Med 39: 5663.
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  • Received : 27 Feb 2015
  • Accepted : 02 Apr 2015

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