1921
Volume 95, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Schistosomiasis is the second most significant parasitic disease in children in several African countries. For this purpose, the “Programme National de Lutte contre les Bilharzioses” (PNLB) was developed in partnership with the World Health Organization (WHO) to control this disease in Senegal. However, geographic isolation of Bedik ethnic groups challenged implementation of the key elements of the schistosomiasis program in eastern Senegal, and therefore, a hospital was established in Ninefescha to improve access to health care as well as laboratory support for this population. The program we have implemented from 2008 in partnership with the PNLB/WHO involved campaigns to 1) evaluate schistosomiasis prevalence in children of 53 villages around Ninefescha hospital, 2) perform a mass drug administration following the protocol established by the PNLB in school-aged children, 3) monitor annual prevalence, 4) implement health education campaigns, and 5) oversee the building of latrines. This campaign led to a drop in schistosomiasis prevalence but highlighted that sustainable schistosomiasis control by praziquantel treatment, awareness of the use of latrines, and inhabitants' voluntary commitment to the program are crucial to improve elimination. Moreover, this study revealed that preschool-aged children, for whom praziquantel was not recommended until 2014 in Senegal, constituted a significant reservoir for the parasite.

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2016-09-07
2017-11-21
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References

  1. Lai YS, Biedermann P, Ekpo UF, Garba A, Mathieu E, Midzi N, Mwinzi P, N'Goran EK, Raso G, Assaré RK, Sacko M, Schur N, Talla I, Tchuenté LA, Touré S, Winkler MS, Utzinger J, Vounatsou P, , 2015. Spatial distribution of schistosomiasis and treatment needs in sub-Saharan Africa: a systematic review and geostatistical analysis. Lancet Infect Dis 15: 927940.[Crossref]
  2. Gray DJ, McManus DP, Li Y, Williams GM, Bergquist R, Ross AG, , 2010. Schistosomiasis elimination: lessons from the past guide the future. Lancet Infect Dis 10: 733736.[Crossref]
  3. Duthe G, Faye SH, Guyavarch E, Arduin P, Kanté AM, Diallo A, Laurent R, Marra A, Pison G, , 2010. Change of protocol in the verbal autopsy method and measure of malaria mortality in rural areas in Senegal [in French]. Bull Soc Pathol Exot 103: 327332.[Crossref]
  4. Colley DG, Bustinduy AL, Secor WE, King CH, , 2014. Human schistosomiasis. Lancet 383: 22532264.[Crossref]
  5. Stothard JR, Sousa-Figueiredo JC, Betson M, Bustinduy A, Reinhard-Rupp J, , 2013. Schistosomiasis in African infants and preschool children: let them now be treated! Trends Parasitol 29: 197205.[Crossref]
  6. World Health Organization, 2011. Report of a Meeting to Review the Results of Studies on the Treatment of Schistosomiasis in Preschool-Aged Children. Geneva, Switzerland: WHO.
  7. Talla I, Kongs A, Verle P, , 1992. Preliminary study of the prevalence of human schistosomiasis in Richard-Toll (the Senegal River basin). Trans R Soc Trop Med Hyg 86: 182.[Crossref]
  8. Meurs L, Mbow M, Vereecken K, Menten J, Mboup S, Polman K, , 2012. Epidemiology of mixed Schistosoma mansoni and Schistosoma haematobium infections in northern Senegal. Int J Parasitol 42: 305311.[Crossref]
  9. Larivière M, Diallo S, Ranque P, , 1964. Existence of foci of bilharziosis due to S. mansoni in the upper Casamance region and in eastern Senegal [in French]. Bull Soc Med Afr Noire Lang Fr 9: 288289.
  10. Wang LD, Chen HG, Guo JG, Zeng XJ, Hong XL, Xiong JJ, Wu XH, Wang XH, Wang LY, Xia G, Hao Y, Chin DP, Zhou XN, , 2009. A strategy to control transmission of Schistosoma japonicum in China. N Engl J Med 360: 121128.[Crossref]
  11. World Health Organization, 2013. Schistosomiasis: Progress Report 2001–2011 and Strategic Plan 2012–2020. Geneva, Switzerland: WHO.
  12. Sousa-Figueiredo JC, Pleasant J, Day M, Betson M, Rollinson D, Montresor A, Kazibwe F, Kabatereine NB, Stothard JR, , 2010. Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing pole. Int Health 2: 103113.[Crossref]
  13. Doenhoff MJ, Hagan P, Cioli D, Southgate V, Pica-Mattoccia L, Botros S, Coles G, Tchuem Tchuenté LA, Mbaye A, Engels D, , 2009. Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs. Parasitology 136: 18251835.[Crossref]
  14. Mutapi F, , 2015. Changing policy and practice in the control of pediatric schistosomiasis. Pediatrics 135: 536544.[Crossref]
  15. Mutapi F, Rujeni N, Bourke C, Mitchell K, Appleby L, Nausch N, Midzi N, Mduluza T, , 2011. Schistosoma haematobium treatment in 1–5 year old children: safety and efficacy of the antihelminthic drug praziquantel. PLoS Negl Trop Dis 5: e1143.[Crossref]
  16. Stothard JR, Sousa-Figueiredo JC, Betson M, Green HK, Seto EY, Garba A, Sacko M, Mutapi F, Vaz Nery S, Amin MA, Mutumba-Nakalembe M, Navaratnam A, Fenwick A, Kabatereine NB, Gabrielli AF, Montresor A, , 2011. Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children. Parasitology 138: 15931606.[Crossref]
  17. Ruganuza DM, Mazigo HD, Waihenya R, Morona D, Mkoji GM, , 2015. Schistosoma mansoni among pre-school children in Musozi village, Ukerewe Island, north-western-Tanzania: prevalence and associated risk factors. Parasit Vectors 8: 377.[Crossref]
  18. Poole H, Terlouw DJ, Naunje A, Mzembe K, Stanton M, Betson M, Lalloo DG, Stothard JR, , 2014. Schistosomiasis in pre-school-age children and their mothers in Chikhwawa district, Malawi with notes on characterization of schistosomes and snails. Parasit Vectors 7: 153.[Crossref]
  19. Coulibaly JT, N'Gbesso YK, N'Guessan NA, Winkler MS, Utzinger J, N'Goran EK, , 2013. Epidemiology of schistosomiasis in two high-risk communities of south Cote d'Ivoire with particular emphasis on pre-school-aged children. Am J Trop Med Hyg 89: 3241.[Crossref]
  20. Ekpo UF, Oluwole AS, Abe EM, Etta HE, Olamiju F, Mafiana CF, , 2012. Schistosomiasis in infants and pre-school-aged children in sub-Saharan Africa: implication for control. Parasitology 139: 835841.[Crossref]
  21. Garba A, Barkire N, Djibo A, Lamine MS, Sofo B, Gouvras AN, Bosqué-Oliva E, Webster JP, Stothard JR, Utzinger J, Fenwick A, , 2010. Schistosomiasis in infants and preschool-aged children: infection in a single Schistosoma haematobium and a mixed S. haematobium-S. mansoni foci of Niger. Acta Trop 115: 212219.[Crossref]
  22. Grimes JE, Croll D, Harrison WE, Utzinger J, Freeman MC, Templeton MR, , 2015. The roles of water, sanitation and hygiene in reducing schistosomiasis: a review. Parasit Vectors 8: 156.[Crossref]
  23. Hodges MH, Paye J, Koroma MM, Nyorkor ED, Fofonah I, Zhang Y, , 2012. High level of Schistosoma mansoni infection in pre-school children in Sierra Leone highlights the need in targeting this age group for praziquantel treatment. Acta Trop 124: 120125.[Crossref]
  24. N'Goran EK, Utzinger J, N'Guessan AN, Müller I, Zamblé K, Lohourignon KL, Traoré M, Sosthène BA, Lengeler C, Tanner M, , 2001. Reinfection with Schistosoma haematobium following school-based chemotherapy with praziquantel in four highly endemic villages in Cote d'Ivoire. Trop Med Int Health 6: 817825.[Crossref]
  25. Garba A, Lamine MS, Barkire N, Djibo A, Sofo B, Gouvras AN, Labbo R, Sebangou H, Webster JP, Fenwick A, Utzinger J, , 2013. Efficacy and safety of two closely spaced doses of praziquantel against Schistosoma haematobium and S. mansoni and re-infection patterns in school-aged children in Niger. Acta Trop 128: 334344.[Crossref]
  26. Ernould JC, Ba K, Sellin B, , 1999. Increase of intestinal schistosomiasis after praziquantel treatment in a Schistosoma haematobium and Schistosoma mansoni mixed focus. Acta Trop 73: 143152.[Crossref]
  27. Landoure A, Dembele R, Goita S, Kané M, Tuinsma M, Sacko M, Toubali E, French MD, Keita AD, Fenwick A, Traoré MS, Zhang Y, , 2012. Significantly reduced intensity of infection but persistent prevalence of schistosomiasis in a highly endemic region in Mali after repeated treatment. PLoS Negl Trop Dis 6: e1774.[Crossref]
  28. Assare RK, Tian-Bi YN, Yao PK, N'Guessan NA, Ouattara M, Yapi A, Coulibaly JT, Meïté A, Hürlimann E, Knopp S, Utzinger J, N'Goran EK, , 2016. Sustaining control of Schistosomiasis mansoni in western Cote d'Ivoire: results from a SCORE study, one year after initial praziquantel administration. PLoS Negl Trop Dis 10: e0004329.[Crossref]
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Supplementary Data

Supplementary PDF

  • Received : 11 Feb 2015
  • Accepted : 25 Mar 2016

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